AB220886

Anti-SHOX抗体

Name: SHOX抗体 (ab220886)| Abcam中文官网
Brand: Abcam Limited
SKU: AB220886
Price: 5757 CNY
Availability: InStock

Anti-SHOX antibody

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(1 Publication)

Rabbit Polyclonal SHOX antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SHOX aa 50-150.

查看别名

PHOG, SHOX, Short stature homeobox protein, Pseudoautosomal homeobox-containing osteogenic protein, Short stature homeobox-containing protein

1 Images

Immunocytochemistry/ Immunofluorescence - Anti-SHOX antibody (AB220886)

ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-SHOX antibody (AB220886)

Immunofluorescent analysis of PFA-fixed/Triton X-100 permeabilized BJ cells labeling SHOX with ab220886 at 4 μg/mL (green).

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Human

应用

ICC/IF

applications

免疫原

Recombinant Fragment Protein within Human SHOX aa 50-150. The exact immunogen used to generate this antibody is proprietary information.

O15266

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

存储溶液

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

The Short Stature Homeobox (SHOX) gene encodes a transcription factor with a molecular mass of approximately 23 kDa. It functions by binding to DNA influencing the regulation of gene expression involved in growth and development. SHOX is located on the pseudoautosomal regions of the X and Y chromosomes. Expression of SHOX occurs mainly in tissues such as bone cartilage and other areas linked to skeletal formation. These features indicate its importance in skeletal system regulation.

Biological function summary

The role of SHOX extends to growth plate development contributing to normal skeletal structure and stature. SHOX influences chondrocyte function and maturation playing a role in bone growth and ossification. It acts within a complex regulatory network interacting with other growth-related proteins to modulate skeletal development during early stages of life. SHOX's presence in these networks highlights its role in foundational growth processes.

Pathways

SHOX is significantly involved in the growth plate signaling and homeostasis pathways. Its activity interconnects with other proteins such as SOX9 and RUNX2 ensuring proper proliferation and differentiation of chondrocytes. The synchrony of SHOX with these key proteins maintains growth balance and skeletal integrity highlighting its participation in the development and maintenance of the growth plate pathway.

Mutations or deletions affecting SHOX result in conditions such as Leri-Weill dyschondrosteosis and idiopathic short stature. These disorders often present with skeletal deformities and reduced stature directly linked to SHOX's role in growth regulation. Interaction between SHOX and other implicated proteins like FGFR3 is evident in these conditions as both factors contribute to the physiological pathways that regulate bone growth and skeletal integrity.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Transcription factor that controls fundamental aspects of growth. Directly activates NPPB transcription in osteogenic cells (PubMed : 11751690, PubMed : 17881654). Preferentially binds DNA elements with the sequence 5'-TAATNNNATTA-3', possibly as a homodimer (PubMed : 11751690).

See full target information SHOX

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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Cell communication and signaling : CCS 23:96 PubMed39966859

2025

REG3A secreted by peritumoral acinar cells enhances pancreatic ductal adenocarcinoma progression via activation of EGFR signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaojing Ren,Yunfei Teng,Kunxin Xie,Xiao He,Gang Chen,Kaini Zhang,Qingyi Liao,Jia Zhang,Xiaohang Zhou,Yating Zhu,Wenyu Song,Yuege Lin,Yi Zhang,Zhijian Xu,Noriaki Maeshige,Xiubin Liang,Dongming Su,Peng Sun,Ying Ding

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Anti-SHOX抗体

Anti-SHOX antibody

Immunocytochemistry/ Immunofluorescence - Anti-SHOX antibody (AB220886)