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AB218251

Anti-SGK3 抗体

Anti-SGK3 antibody

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Rabbit Polyclonal SGK3 antibody. Suitable for IHC-P and reacts with Mouse, Human samples. Immunogen corresponding to Synthetic Peptide within Human SGK3 aa 1-100 conjugated to Keyhole Limpet Haemocyanin.

查看别名

CISK, SGKL, SGK3, Serine/threonine-protein kinase Sgk3, Cytokine-independent survival kinase, Serum/glucocorticoid-regulated kinase 3, Serum/glucocorticoid-regulated kinase-like

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SGK3 antibody (AB218251)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SGK3 antibody (AB218251)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded human kidney tissue labeling SGK3 with ab218251 at 1/200 dilution, followed by conjugation to the secondary antibody and DAB staining.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SGK3 antibody (AB218251)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SGK3 antibody (AB218251)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded human breast carcinoma tissue labeling SGK3 with ab218251 at 1/200 dilution, followed by conjugation to the secondary antibody and DAB staining.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SGK3 antibody (AB218251)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SGK3 antibody (AB218251)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded mouse pancreas tissue labeling SGK3 with ab218251 at 1/200 dilution, followed by conjugation to the secondary antibody and DAB staining.

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

No

反应种属

Mouse, Human

应用

IHC-P

applications

免疫原

Synthetic Peptide within Human SGK3 aa 1-100 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

Q96BR1

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p></p>" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Protein A
存储溶液
pH: 7.4 Preservative: 0.02% Proclin 300 Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

SGK3 also known as Serum/Glucocorticoid Regulated Kinase Family Member 3 or CISK is a serine/threonine protein kinase with a molecular weight of approximately 56 kDa. It plays a role in the regulation of ion channels cell growth and survival by phosphorylating other proteins. SGK3 is expressed in various tissues including the brain kidney and liver. Expression is often responsive to changes in serum and glucocorticoid levels.
Biological function summary

SGK3 contributes to cellular growth and metabolism. This protein integrates signals involved in the response to oxidative stress and plays a part in the cellular response to environmental changes. As a member of the AGC kinase family SGK3 shares structural and functional similarities with AKT another significant kinase involved in growth regulation and apoptosis control.

Pathways

SGK3 functions within the PI3K/AKT signaling pathway and also interacts in the mTOR signaling network. These pathways are critical for regulating cell proliferation survival and metabolism. SGK3 can phosphorylate several downstream targets including FOXO3a and NDRG1 contributing to cellular resistance to stress and promoting survival pathways.

SGK3 has been linked to cancer and metabolic disorders. Its role in the PI3K/AKT pathway means that deregulated SGK3 activity can contribute to oncogenesis often through pathways shared with proteins such as AKT and mTOR. Aberrant SGK3 expression or function is also related to insulin resistance impacting glucose metabolism and associating it with contributors to type 2 diabetes.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, proliferation, survival and migration. Up-regulates Na(+) channels : SCNN1A/ENAC and SCN5A, K(+) channels : KCNA3/KV1.3, KCNE1, KCNQ1 and KCNH2/HERG, epithelial Ca(2+) channels : TRPV5 and TRPV6, chloride channel : BSND, creatine transporter : SLC6A8, Na(+)/dicarboxylate cotransporter : SLC13A2/NADC1, Na(+)-dependent phosphate cotransporter : SLC34A2/NAPI-2B, amino acid transporters : SLC1A5/ASCT2 and SLC6A19, glutamate transporters : SLC1A3/EAAT1, SLC1A6/EAAT4 and SLC1A7/EAAT5, glutamate receptors : GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger : SLC9A3/NHE3, and the Na(+)/K(+) ATPase. Plays a role in the regulation of renal tubular phosphate transport and bone density. Phosphorylates NEDD4L and GSK3B. Positively regulates ER transcription activity through phosphorylation of FLII. Negatively regulates the function of ITCH/AIP4 via its phosphorylation and thereby prevents CXCR4 from being efficiently sorted to lysosomes.
See full target information SGK3
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