AB231256

Anti-SFXN1/TCC抗体

Name: SFXN1/TCC抗体 (ab231256)| Abcam中文官网
Brand: Abcam Limited
SKU: AB231256
Price: 4748 CNY
Availability: InStock

Anti-SFXN1/TCC antibody

Be the first to review this product! Submit a review

(1 Publication)

Rabbit Polyclonal SFXN1/TCC antibody. Suitable for WB, IHC-P and reacts with Mouse samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Mouse Sfxn1 aa 1-150.

查看别名

Sideroflexin-1, Sfxn1

3 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SFXN1/TCC antibody (AB231256)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SFXN1/TCC antibody (AB231256)

Formalin-fixed, paraffin-embedded mouse kidney tissue stained for SFXN1/TCC with ab231256 at 20 μg/ml in immunohistochemical analysis. DAB staining.

Supplier Data

Western blot - Anti-SFXN1/TCC antibody (AB231256)

All lanes:

Western blot - Anti-SFXN1/TCC antibody (ab231256) at 1 µg

All lanes:

Mouse liver lysate

Secondary

All lanes:

HRP-Linked Guinea pig Anti-Rabbit antibody at 1/1000 dilution

Predicted band size: 36 kDa

false

Supplier Data

Western blot - Anti-SFXN1/TCC antibody (AB231256)

All lanes:

Western blot - Anti-SFXN1/TCC antibody (ab231256) at 2 µg/mL

All lanes:

Recombinant mouse SFXN1/TCC protein

Predicted band size: 254 kDa,36 kDa

false

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Mouse

应用

WB, IHC-P

applications

免疫原

Recombinant Fragment Protein within Mouse Sfxn1 aa 1-150. The exact immunogen used to generate this antibody is proprietary information.

Q99JR1

style

left-column

反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-20 µg/mL", "IHCP-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Pig": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Sheep": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

style

left-column

style

left-column

性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

纯化说明

ab231256 was purified by antigen-specific affinity chromatography followed by Protein A affinity chromatography.

存储溶液

pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

style

left-column

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Sideroflexin 1 (SFXN1) also known as TCC is an integral mitochondrial membrane protein responsible for iron transport. Approximately 35 kDa in size SFXN1 plays an important role in the movement of iron into mitochondria which is essential for various cellular functions. This protein is expressed extensively across different tissues with significant expression observed in metabolically active tissues such as the liver heart and muscle.

Biological function summary

The transport activity of SFXN1 has significant impact on cellular iron homeostasis. It is part of mitochondrial iron-sulfur cluster (ISC) assembly which is necessary for a wide range of cellular activities. SFXN1 associates with other mitochondrial transport proteins to ensure the proper supply of iron for heme and ISC production both of which are critical for cellular respiration and energy production.

Pathways

SFXN1 plays an important role in maintaining mitochondrial function through its involvement in the ISC assembly pathway and heme synthesis. Its function is closely tied to other transport proteins such as mitoferrin-1 and mitoferrin-2 which contribute to iron homeostasis within the mitochondria. The role of SFXN1 in these pathways underlines its importance in energy metabolism and cellular respiration.

Alterations in SFXN1 function are associated with conditions related to iron metabolism dysfunction such as mitochondrial diseases. Dysregulation of SFXN1 impacts iron homeostasis leading to complications like sideroblastic anemia. The connection between SFXN1 and other proteins involved in these pathways such as ALAS2 in heme synthesis highlights its relevance to these disease processes.

style

left-column

style

left-column

产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

style

left-column

靶点信息

Amino acid transporter importing serine, an essential substrate of the mitochondrial branch of the one-carbon pathway, into mitochondria. Mitochondrial serine is then converted to glycine and formate, which exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors. May also transport other amino acids including alanine and cysteine.

See full target information Sfxn1

style

left-column

文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Heliyon 10:e33212 PubMed39021933

2024

TMT-based proteomics analysis of the blood enriching mechanism of the total Tannins of Gei Herba in mice.

Applications

Unspecified application

Species

Unspecified reactive species

Wenbi Mu,Cancan Duan,Jingwen Ao,Fanpan Du,Jianyong Zhang

View all publications

style

left-column

style

left-column

style

right-column

Abcam Product Promise

我们致力于为您的研究提供高质量的试剂，为您科研的每一步提供支持。若我们的产品未能达到预期性能，我们向您提供 Abcam Product Promise 保障。

详情请参阅我们的条款与条件。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-SFXN1/TCC抗体

Anti-SFXN1/TCC antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SFXN1/TCC antibody (AB231256)

Western blot - Anti-SFXN1/TCC antibody (AB231256)

Western blot - Anti-SFXN1/TCC antibody (AB231256)