AB137247

Anti-SFRS7/SRSF7抗体

Name: SFRS7/SRSF7抗体 (ab137247)| Abcam中文官网
Brand: Abcam Limited
SKU: AB137247
Price: 4744 CNY
Availability: InStock

Anti-SFRS7/SRSF7 antibody

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(5 Publications)

Rabbit Polyclonal SFRS7/SRSF7 antibody. Suitable for IHC-P, IP and reacts with Mouse, Human samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human SRSF7 aa 50-150.

查看别名

SFRS7, SRSF7, Serine/arginine-rich splicing factor 7, Splicing factor 9G8

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SFRS7/SRSF7 antibody (AB137247)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SFRS7/SRSF7 antibody (AB137247)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human colon carcinoma (left) and mouse renal cell carcinoma (right) tissues labelling SRSF7/SRSF7 with ab137247 at 1/5000 (0.2μg/ml) and 1/1000 (1μg/ml) . Detection : DAB.

Unknown

Immunoprecipitation - Anti-SFRS7/SRSF7 antibody (AB137247)

Immunoprecipitation with ab137247 at 6μg/mg lysate. 1 mg of HeLa whole cell lysate used for IP (20% of IP loaded). Subsequent WB detection used an anti-SFRS7/SRSF7 antibody which recognizes a downstream epitope at 1 μg/ml. Detected by chemiluminescence with exposure time of 30 seconds.

All lanes:

Immunoprecipitation - Anti-SFRS7/SRSF7 antibody (ab137247)

Predicted band size: 27 kDa

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关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Mouse, Human

应用

IHC-P, IP

applications

免疫原

Synthetic Peptide within Human SRSF7 aa 50-150. The exact immunogen used to generate this antibody is proprietary information.

Q16629

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/1000 - 1/5000", "IHCP-species-notes": " Perform heat-mediated antigen retrieval before commencing with IHC staining protocol.", "IP-species-checked": "testedAndGuaranteed", "IP-species-dilution-info": "2-10 µg/mg of lysate", "IP-species-notes": "" }, "Mouse": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/1000 - 1/5000", "IHCP-species-notes": " Perform heat-mediated antigen retrieval before commencing with IHC staining protocol.", "IP-species-checked": "guaranteed", "IP-species-dilution-info": "", "IP-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "" }, "Chicken": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "" }, "Chimpanzee": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "" }, "Cow": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "" }, "Dog": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "" }, "Gorilla": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "" }, "Guinea pig": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "" }, "Horse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "" }, "Orangutan": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "" }, "Pig": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "" }, "Platypus": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "" }, "Rabbit": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "" }, "Rhesus monkey": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "" }, "Turkey": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

纯化说明

ab137247 was affinity purified using an epitope specific to SRSF7/SRSF7 immobilized on solid support

存储溶液

pH: 7 - 8 Preservative: 0.09% Sodium azide Constituents: 99% Tris citrate/phosphate

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

SFRS7 also known as SRSF7 is a member of the serine/arginine-rich family of proteins that functions as an essential splicing factor. It has a mass of approximately 27 kDa. SRSF7 shows expression in various tissues with notable presence in the nucleoplasm of cells. Mechanically SRSF7 has binding affinity for RNA sequences facilitating alternative splicing by interacting with pre-mRNA. This protein plays a significant role in post-transcriptional regulation influencing the maturation and diversity of mRNA transcripts.

Biological function summary

SRSF7 contributes to the regulation of gene expression and is involved in spliceosome formation though it is not strictly part of the spliceosomal core complex. It influences exon skipping and inclusion which affects various functional mRNA variants. SRSF7 enables cellular responses to changes in internal and external environments by altering gene expression patterns. This flexibility positions it as an important player in processes such as cell cycle regulation and apoptosis.

Pathways

SRSF7 operates within the general mRNA processing pathway and plays a part in the spliceosome pathway. SRSF7 interacts with other splicing factors like SRSF1 which promotes its functional diversity. These proteins collectively enable precise and correct splicing of mRNA which is critical in maintaining cellular homeostasis and responding to physiological changes.

Abnormalities in SRSF7 expression or function can relate to cancer and neurodegenerative disorders. Dysregulation of mRNA splicing where SRSF7 plays a role can drive oncogenic transformations in cells linking it to various forms of cancer. Also SRSF7 and splicing-related proteins such as hnRNPs are observed in dysfunctional states within neurodegenerative conditions suggesting splicing alterations contribute to disease pathogenesis. Understanding SRSF7's role allows for better comprehension of these disorders and potential therapeutic strategies.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Required for pre-mRNA splicing. Can also modulate alternative splicing in vitro. Represses the splicing of MAPT/Tau exon 10. May function as export adapter involved in mRNA nuclear export such as of histone H2A. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity. RNA-binding is semi-sequence specific.

See full target information SRSF7

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文献 (5)

Recent publications for all applications. Explore the full list and refine your search

International journal of molecular sciences 26: PubMed40649911

2025

Multi-Omics Integration: Predicting Progression and Optimizing Clinical Treatment of Hepatocellular Carcinoma Through Malignant-Cell-Related Genes.

Applications

Unspecified application

Species

Unspecified reactive species

Qianwen Wang,Lingli Cheng,Honglin Yan,Jingping Yuan

Heliyon 10:e31972 PubMed38868058

2024

Downregulation of hsa_circTLK1 represses non-small cell lung cancer progression by regulating miR-876-3p/SRSF7 axis.

Applications

Unspecified application

Species

Unspecified reactive species

Xinzhe Dong,Hui Tian,Peng Ren,Yanxia Liu,Lin Wang

Biochimica et biophysica acta. Molecular basis of disease 1870:166983 PubMed38070581

2023

BRD9 status is a major contributor for cysteine metabolic remodeling through MST and EAAT3 modulation in malignant melanoma.

Applications

Unspecified application

Species

Unspecified reactive species

Ana Hipólito,Renato Xavier,Cheila Brito,Ana Tomás,Isabel Lemos,Luís C Cabaço,Fernanda Silva,Abel Oliva,Duarte C Barral,João B Vicente,Luís G Gonçalves,Marta Pojo,Jacinta Serpa

Viruses 14: PubMed35062264

2021

The Thiazole-5-Carboxamide GPS491 Inhibits HIV-1, Adenovirus, and Coronavirus Replication by Altering RNA Processing/Accumulation.

Applications

Unspecified application

Species

Unspecified reactive species

Subha Dahal,Ran Cheng,Peter K Cheung,Terek Been,Ramy Malty,Melissa Geng,Sarah Manianis,Lulzim Shkreta,Shahrazad Jahanshahi,Johanne Toutant,Rose Chan,Sean Park,Mark A Brockman,Mohan Babu,Samira Mubareka,Karen Mossman,Arinjay Banerjee,Scott Gray-Owen,Martha Brown,Walid A Houry,Benoit Chabot,David Grierson,Alan Cochrane

PLoS pathogens 16:e1008307 PubMed32069328

2020

An activator of G protein-coupled receptor and MEK1/2-ERK1/2 signaling inhibits HIV-1 replication by altering viral RNA processing.

Applications

Unspecified application

Species

Unspecified reactive species

Raymond W Wong,Ahalya Balachandran,Peter K Cheung,Ran Cheng,Qun Pan,Peter Stoilov,P Richard Harrigan,Benjamin J Blencowe,Donald R Branch,Alan Cochrane

View all publications

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Anti-SFRS7/SRSF7抗体

Anti-SFRS7/SRSF7 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SFRS7/SRSF7 antibody (AB137247)

Immunoprecipitation - Anti-SFRS7/SRSF7 antibody (AB137247)