Anti-SETD1B抗体(ab112049)
Key features and details
- Rabbit polyclonal to SETD1B
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-SETD1B抗体
参阅全部 SETD1B 一抗 -
描述
兔多克隆抗体to SETD1B -
宿主
Rabbit -
经测试应用
适用于: IHC-Pmore details -
种属反应性
与反应: Human
预测可用于: Rabbit, Cow, Chimpanzee, Gorilla
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免疫原
Synthetic peptide corresponding to Human SETD1B aa 350-400.
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阳性对照
- Human Breast Carcinoma, Human Ovarian Carcinoma, and Human Testicular Seminoma tissues
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
pH: 6.8
Preservative: 0.09% Sodium azide
Constituents: 99% Tris citrate/phosphate, 0.1% BSA -
Concentration information loading... -
纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab112049于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| IHC-P |
1/100 - 1/500. Epitope exposure is recommended.
Epitope exposure with citrate buffer will enhance staining.
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| 说明 |
|---|
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IHC-P
1/100 - 1/500. Epitope exposure is recommended. Epitope exposure with citrate buffer will enhance staining. |
靶标
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功能
Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. The non-overalpping localization with SETD1A suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression. Specifically tri-methylates 'Lys-4' of histone H3 in vitro. -
序列相似性
Contains 1 post-SET domain.
Contains 1 RRM (RNA recognition motif) domain.
Contains 1 SET domain. -
细胞定位
Nucleus speckle. Chromosome. Localizes to a largely non-overlapping set of euchromatic nuclear speckles with SETD1A, suggesting that SETD1A and SET1B each bind to a unique set of target genes. - Information by UniProt
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数据库链接
- Entrez Gene: 23067 Human
- Omim: 611055 Human
- SwissProt: Q9UPS6 Human
- Unigene: 507122 Human
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别名
- FLJ20803 antibody
- Histone-lysine N-methyltransferase SETD1B antibody
- hSET1B antibody
see all
图片
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SETD1B antibody (ab112049)
Staining of Human SETD1B in a Formalin/PFA-fixed paraffin-embedded section of Human Breast Carcinoma using ab112049 at a dilution of 1/250.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SETD1B antibody (ab112049)Staining of Human SETD1B in a Formalin/PFA-fixed paraffin-embedded section of Human Ovarian Carcinoma using ab112049 at a dilution of 1/250.
数据表及文件
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Datasheet download
文献 (0)
ab112049 尚未被引用在任何文献中。
