Key features and details
- Mouse monoclonal [KT28] to SERPING1
- Suitable for: Indirect ELISA
- Reacts with: Human
- Isotype: IgG1
参阅全部 SERPING1 一抗
描述小鼠单克隆抗体[KT28] to SERPING1
经测试应用适用于: Indirect ELISAmore details
Full length native protein (purified) corresponding to Human SERPING1.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
存放说明Shipped at 4°C. Store at 4°C (stable for up to 12 months). Store at -20°C or -80°C.
存储溶液Preservative: 0.1% Sodium azide
Concentration information loading...
纯度Protein A purified
The Abpromise guarantee
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
功能Activation of the C1 complex is under control of the C1-inhibitor. It forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May play a potentially crucial role in regulating important physiological pathways including complement activation, blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. Inhibits chymotrypsin and kallikrein.
疾病相关Defects in SERPING1 are the cause of hereditary angioedema (HAE) [MIM:106100]; also called hereditary angioneurotic edema (HANE). HAE is an autosomal dominant disorder characterized by episodic local subcutaneous edema and submucosal edema involving the upper respiratory and gastrointestinal tracts. HAE due to C1 esterase inhibitor deficiency is comprised of two clinically indistinguishable forms. In HAE type 1, representing 85% of patients, serum levels of C1 esterase inhibitor are less than 35% of normal. In HAE type 2, the levels are normal or elevated, but the protein is non-functional.
序列相似性Belongs to the serpin family.
翻译后修饰Highly glycosylated (49%) with N- and O-glycosylation.
Can be proteolytically cleaved by E.coli stcE.
- Information by UniProt
- C1 esterase inhibitor antibody
- C1 Inh antibody
- C1 inhibiting factor antibody
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.