Anti-Semaphorin 7a抗体[MEM-150] (ab8222)
![Flow Cytometry - Anti-Semaphorin 7a antibody [MEM-150] (ab8222)](https://www.abcam.cn/ps/products/8/ab8222/Images/ab8222-331846-anti-semaphorin-7a-antibody-mem-150-flow-cytometry.jpg "Flow Cytometry - Anti-Semaphorin 7a antibody [MEM-150] (ab8222)")
Key features and details
- Mouse monoclonal [MEM-150] to Semaphorin 7a
- Suitable for: Flow Cyt
- Reacts with: Human
- Isotype: IgM
Related conjugates and formulations
概述
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产品名称
Anti-Semaphorin 7a抗体[MEM-150]
参阅全部 Semaphorin 7a 一抗 -
描述
小鼠单克隆抗体[MEM-150] to Semaphorin 7a -
宿主
Mouse -
特异性
Human CD108 (JMH blood group antigen). -
经测试应用
适用于: Flow Cytmore details -
种属反应性
与反应: Human -
免疫原
Tissue, cells or virus corresponding to Human Semaphorin 7a. T cell line HPB-ALL
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
存储溶液
pH: 8.0
Preservative: 0.097% Sodium azide
Constituent: PBS -
Concentration information loading... -
纯度
Proprietary Purification -
纯化说明
Purified from TCS. Purified by precipitation and chromatography. Purity >95% by SDS-PAGE. -
克隆
单克隆 -
克隆编号
MEM-150 -
骨髓瘤
unknown -
同种型
IgM -
轻链类型
unknown -
研究领域
相关产品
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Alternative Versions
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Compatible Secondaries
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Recombinant Protein
应用
靶标
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功能
Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of proinflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes. -
组织特异性
Detected in skin keratinocytes and on endothelial cells from skin blood vessels (at protein level). Expressed in fibroblasts, keratinocytes, melanocytes, placenta, testis, ovary, spleen, brain, spinal chord, lung, heart, adrenal gland, lymph nodes, thymus, intestine and kidney. -
序列相似性
Belongs to the semaphorin family.
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Contains 1 PSI domain.
Contains 1 Sema domain. -
细胞定位
Cell membrane. Detected in a punctate pattern on the cell membrane of basal and supra-basal skin keratinocytes. - Information by UniProt
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数据库链接
- Entrez Gene: 8482 Human
- Omim: 607961 Human
- SwissProt: O75326 Human
- Unigene: 24640 Human
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别名
- CD 108 antibody
- CD108 antibody
- CD108 antigen antibody
see all
图片
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Flow Cytometry - Anti-Semaphorin 7a antibody [MEM-150] (ab8222)Flow cytometry of human peripheral blood cells with ab8222 at 3 µg/ml
实验方案
数据表及文件
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SDS download
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Datasheet download
文献 (4)
ab8222 被引用在 4 文献中.
- Zhao Z et al. LncRNA DLX6-AS1 Promotes Malignant Phenotype and Lymph Node Metastasis in Prostate Cancer by Inducing LARGE Methylation. Front Oncol 10:1172 (2020). PubMed: 32850336
- Drukker M et al. Isolation of primitive endoderm, mesoderm, vascular endothelial and trophoblast progenitors from human pluripotent stem cells. Nat Biotechnol 30:531-42 (2012). Human . PubMed: 22634564
- Angelisova P et al. Characterization of the human leukocyte GPI-anchored glycoprotein CDw108 and its relation to other similar molecules. Immunobiology 200:234-45 (1999). PubMed: 10416131
- Mudad R et al. Evidence that CDw108 membrane protein bears the JMH blood group antigen. Transfusion 35:566-70 (1995). PubMed: 7631388