AB221620

Anti-SEMA4F抗体

Name: SEMA4F抗体 (ab221620)| Abcam中文官网
Brand: Abcam Limited
SKU: AB221620
Price: 5757 CNY
Availability: InStock

Anti-SEMA4F antibody

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(1 Publication)

Rabbit Polyclonal SEMA4F antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SEMA4F aa 1-150.

查看别名

SEMAM, SEMAW, SEMA4F, Semaphorin-4F, Semaphorin-M, Semaphorin-W, Sema M, Sema W

1 Images

Immunocytochemistry/ Immunofluorescence - Anti-SEMA4F antibody (AB221620)

ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-SEMA4F antibody (AB221620)

U-251 MG cells stained for SEMA4F (green) using ab221620 (4 μg/ml) in ICC/IF.

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Human

应用

ICC/IF

applications

免疫原

Recombinant Fragment Protein within Human SEMA4F aa 1-150. The exact immunogen used to generate this antibody is proprietary information.

O95754

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" }, "Mouse": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

存储溶液

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

SEMA4F also known as Semaphorin-4F is a member of the semaphorin family of proteins. It has an approximate molecular mass of 85 kDa. This protein is expressed mainly in the central nervous system particularly in neurons and glial cells. SEMA4F is a membrane-bound protein that plays a role in axonal guidance interacting with specific cell surface receptors during neural development.

Biological function summary

SEMA4F serves as a mediator in cell signaling processes critical for neuronal connections. It is part of a larger signaling complex that includes plexins and neuropilins which help guide axonal pathfinding and neuronal wiring. SEMA4F influences neurite outgrowth and contributes to the establishment of neural networks by regulating cytoskeletal dynamics and cell adhesion properties.

Pathways

Several cellular signaling mechanisms involve SEMA4F interactions. SEMA4F is involved in the PI3K/Akt and MAPK/ERK pathways both essential for cell growth and survival. Within these pathways SEMA4F interacts with Plexin-B1 which transduces intracellular signals affecting cytoskeleton reorganization. These interactions highlight its role in neurodevelopment and differentiation.

SEMA4F has associations with neurodegenerative diseases and cancer. Aberrant SEMA4F expression has links to Alzheimer's disease where it interacts with proteins like Β-amyloid precursor protein potentially influencing disease progression. In cancer biology abnormal SEMA4F signaling is observed in gliomas with its interactions with Plexin-B1 potentially affecting tumor growth and metastasis. Understanding these connections may provide insights into therapeutic strategies for managing these conditions.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Probable cell surface receptor that regulates oligodendroglial precursor cell migration (By similarity). Might also regulate differentiation of oligodendroglial precursor cells (By similarity). Has growth cone collapse activity against retinal ganglion-cell axons (By similarity).

See full target information SEMA4F

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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Translational andrology and urology 12:176-186 PubMed36915888

2023

Identification and validation of immunohistochemical marker panels to predict the prognosis of muscle invasive bladder cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Yidie Ying,Ziwei Wang,Yuxin Tan,Haotian Cao,Hongliang Gao,Zhensheng Zhang,Shuxiong Zeng,Chuanliang Xu

View all publications

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Anti-SEMA4F抗体

Anti-SEMA4F antibody

Immunocytochemistry/ Immunofluorescence - Anti-SEMA4F antibody (AB221620)