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AB185483

Anti-Secretory lectin ZG16抗体

Anti-Secretory lectin ZG16 antibody

5

(1 Review)

|

(2 Publications)

Rabbit Polyclonal Secretory lectin ZG16 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ZG16 aa 1-100.

查看别名

Zymogen granule membrane protein 16, Zymogen granule protein 16, hZG16, Secretory lectin ZG16, ZG16

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Secretory lectin ZG16 antibody (AB185483)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Secretory lectin ZG16 antibody (AB185483)

Paraffin embedded human rectum tissue stained for ZG16 using ab185483 at 1/1000 dilution in immunohistochemical analysis.

Heat mediated antigen retrieval was performed with citrate buffer pH 6 before the IHC staining protocol.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Secretory lectin ZG16 antibody (AB185483)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Secretory lectin ZG16 antibody (AB185483)

Paraffin embedded human colon tissue stained for ZG16 using ab185483 at 1/1000 dilution in immunohistochemical analysis.

Heat mediated antigen retrieval was performed with citrate buffer pH 6 before the IHC staining protocol.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Secretory lectin ZG16 antibody (AB185483)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Secretory lectin ZG16 antibody (AB185483)

Paraffin embedded human liver tissue stained for ZG16 using ab185483 at 1/1000 dilution in immunohistochemical analysis. Shows low expression as expected.

Heat mediated antigen retrieval was performed with citrate buffer pH 6 before the IHC staining protocol.

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

No

反应种属

Human

应用

IHC-P

applications

免疫原

Recombinant Fragment Protein within Human ZG16 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.

O60844

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/500 - 1/1000", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }
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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Immunogen
存储溶液
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Secretory lectin ZG16 also known as ZG16p (zymogen granule protein 16) plays an important role in the cell by binding carbohydrates. This protein has a molecular mass of approximately 16 kDa and is involved in glycan recognition showcasing its affinity for mannose. ZG16 is expressed mainly in the pancreas notably in the zymogen granules of acinar cells where it contributes to the packaging of secretory products.
Biological function summary

This lectin-based protein maintains the integrity and function of zymogen granules. ZG16 interacts with glycosaminoglycans facilitating the trafficking and localization of these granules within the cell. It is not known to be part of a larger protein complex but might interact transiently with other components of the zymogen granules. This molecular activity assists in efficient enzyme storage and secretion fundamental for normal pancreatic function.

Pathways

ZG16 plays a role in the cellular processes of exocytosis and protein trafficking. Its function aligns with the MAPK signaling pathway as well as the vesicle-mediated transport pathway. In these pathways ZG16's interaction with proteins like MIST1 and RabGTPase influences granule maturation and secretory pathways which are essential for the controlled release of digestive enzymes.

ZG16 links to conditions such as pancreatitis and cystic fibrosis where proper enzyme secretion is compromised. During pancreatitis inflammation affects ZG16 expression altering granule dynamics and impacting digestion. In cystic fibrosis although the primary defect lies in CFTR changes in ZG16 expression may contribute to malabsorption issues due to improper enzyme activation. Understanding the role of ZG16 in these diseases provides insights into potential therapeutic avenues targeting these proteins.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

May play a role in protein trafficking. May act as a linker molecule between the submembranous matrix on the luminal side of zymogen granule membrane (ZGM) and aggregated secretory proteins during granule formation in the TGN.
See full target information ZG16
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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

International journal of molecular sciences 26: PubMed40141069

2025

In Vitro Analysis of Probiotic Properties Related to the Adaptation of to Intestinal Microenvironment and Involvement of S-Layer Proteins.

Applications

Unspecified application

Species

Unspecified reactive species

Nina Čuljak,Krešo Bendelja,Andreja Leboš Pavunc,Katarina Butorac,Martina Banić,Ana Savić Mlakar,Željko Cvetić,Jana Hrsan,Jasna Novak,Jagoda Šušković,Blaženka Kos

Nature communications 10:5492 PubMed31792210

2019

Genome-wide CRISPR screen identifies ELP5 as a determinant of gemcitabine sensitivity in gallbladder cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Sunwang Xu,Ming Zhan,Cen Jiang,Min He,Linhua Yang,Hui Shen,Shuai Huang,Xince Huang,Ruirong Lin,Yongheng Shi,Qiang Liu,Wei Chen,Man Mohan,Jian Wang
View all publications
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搭配使用产品

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