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AB151258

Anti-SEC23B 抗体

Anti-SEC23B antibody

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(5 Publications)

Rabbit Polyclonal SEC23B antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Recombinant Fragment Protein within Human SEC23B aa 1-250.

查看别名

Protein transport protein Sec23B, hSec23B, SEC23-related protein B, SEC23B

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SEC23B antibody (AB151258)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SEC23B antibody (AB151258)

Immunohistochemical analysis of paraffin embedded Human Ca922 oral cancer xenograft labeling SEC23B with ab151258 antibody at 1/500.

Western blot - Anti-SEC23B antibody (AB151258)
  • WB

Unknown

Western blot - Anti-SEC23B antibody (AB151258)

7.5% SDS PAGE

All lanes:

Western blot - Anti-SEC23B antibody (ab151258) at 1/1000 dilution

All lanes:

Raji whole cell lysate at 30 µg

Predicted band size: 86 kDa

false

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

No

反应种属

Human

应用

WB, IHC-P

applications

免疫原

Recombinant Fragment Protein within Human SEC23B aa 1-250. The exact immunogen used to generate this antibody is proprietary information.

Q15437

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替代产品

Primary Antibodies

AB245212

Anti-SEC23B antibody [EPR22723-24]

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Primary Antibodies

AB270756

Anti-SEC23B antibody [EPR22723-24] - BSA and Azide free

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Immunocytochemistry/ Immunofluorescence - Anti-SEC23B antibody [EPR22723-24] - BSA and Azide free (AB270756)

  • 0
  • 0

搭配使用产品

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  • 0
Primary Antibodies

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Primary Antibodies

AB22595

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Primary Antibodies

AB21685

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "<p>Alternatively Tris-EDTA buffer ( pH8.0) may be used.</p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" } } }
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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Immunogen
存储溶液
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
运输条件
Blue Ice
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

SEC23B also known as Protein Transport Protein Sec23B is a component of the coat protein complex II (COPII) which mediates transport from the endoplasmic reticulum to the Golgi apparatus. SEC23B weighs approximately 88 kDa and acts as a GTPase activating protein that regulates the COPII complex assembly. SEC23B broadly expresses in many tissues including high levels in the pancreas and liver suggesting its essential role in cellular transport processes.
Biological function summary

SEC23B functions in vesicular trafficking within cells. In the COPII complex it interacts with SEC24 proteins to form a structural framework critical for cargo selection and vesicle budding. SEC23B does not work alone and is part of a larger protein complex that includes SEC24 SAR1 and SEC13/31 which facilitates proper vesicle formation and trafficking. These interactions enable cells to accurately and efficiently transport necessary proteins and lipids through the secretory pathway.

Pathways

SEC23B is essential in the ER-to-Golgi transport pathway and plays a significant role in maintaining protein homeostasis. The secretory pathway requires SEC23B to cooperate with other proteins like SEC24C and SEC31A ensuring that cargo proteins are correctly packaged and delivered to their destination within the cell. This process is vital for the function of other pathways such as the unfolded protein response as it prevents the accumulation of misfolded proteins in the endoplasmic reticulum.

SEC23B mutations have links to Congenital Dyserythropoietic Anemia type II (CDA II) which manifests as ineffective erythropoiesis and improper glycosylation of red blood cell membrane proteins. SEC23B is also associated with pancreatic dysfunctions considering its high expression in the tissue although detailed mechanisms are less understood. In CDA II SEC23B's dysfunction affects its interaction with associated proteins like SEC24B disrupting normal vesicular trafficking and functional erythrocyte production.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex.
See full target information SEC23B
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文献 (5)

Recent publications for all applications. Explore the full list and refine your search

International journal of molecular sciences 24: PubMed37373084

2023

New Cases and Mutations in Gene Causing Congenital Dyserythropoietic Anemia Type II.

Applications

Unspecified application

Species

Unspecified reactive species

Melina Mara Musri,Veronica Venturi,Xènia Ferrer-Cortès,Lídia Romero-Cortadellas,Gonzalo Hernández,Pilar Leoz,María Pilar Ricard Andrés,Marta Morado,María Del Carmen Fernández Valle,David Beneitez Pastor,Ana Ortuño Cabrero,Maite Moreno Gamiz,Leonor Senent Peris,Amanda Isabel Perez-Valencia,Santiago Pérez-Montero,Cristian Tornador,Mayka Sánchez

The Journal of clinical investigation 132: PubMed35143418

2022

Sec13 promotes oligodendrocyte differentiation and myelin repair through autocrine pleiotrophin signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Zhixiong Liu,Minbiao Yan,Wanying Lei,Rencai Jiang,Wenxiu Dai,Jialin Chen,Chaomeng Wang,Li Li,Mei Wu,Ximing Nian,Daopeng Li,Di Sun,Xiaoqi Lv,Chaoying Wang,Changchuan Xie,Luming Yao,Caiming Wu,Jin Hu,Naian Xiao,Wei Mo,Zhanxiang Wang,Liang Zhang

Cell death & disease 12:304 PubMed33753724

2021

Non-canonical role of wild-type SEC23B in the cellular stress response pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Lamis Yehia,Darren Liu,Shuai Fu,Pranav Iyer,Charis Eng

Human molecular genetics 27:3154-3164 PubMed29893852

2018

Non-canonical role of cancer-associated mutant SEC23B in the ribosome biogenesis pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Lamis Yehia,Supriya Jindal,Anton A Komar,Charis Eng

American journal of human genetics 97:661-76 PubMed26522472

2015

Germline Heterozygous Variants in SEC23B Are Associated with Cowden Syndrome and Enriched in Apparently Sporadic Thyroid Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Lamis Yehia,Farshad Niazi,Ying Ni,Joanne Ngeow,Madhav Sankunny,Zhigang Liu,Wei Wei,Jessica L Mester,Ruth A Keri,Bin Zhang,Charis Eng
View all publications
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