AB25117

Anti-SDF1 抗体

Name: SDF1抗体 (ab25117)| Abcam中文官网
Brand: Abcam Limited
SKU: AB25117
Price: 5255 CNY
Availability: InStock
Rating: 3 (11 reviews)

Anti-SDF1 antibody

(11 Reviews)

(71 Publications)

Anti-SDF1 antibody (ab25117) is a rabbit polyclonal antibody detecting SDF1 in Western Blot, Flow Cytometry, IP, IHC-P, IHC-Fr. Suitable for Mouse, Rat.

- Over 60 publications
- Trusted since 2006

查看别名

Sdf1, Cxcl12, Stromal cell-derived factor 1, SDF-1, 12-O-tetradecanoylphorbol 13-acetate repressed protein 1, C-X-C motif chemokine 12, Pre-B cell growth-stimulating factor, Thymic lymphoma cell-stimulating factor, TPAR1, PBSF, TLSF

1 Images

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Western blot - Anti-SDF1 antibody (AB25117)

Detection of recombinant Mouse SDF1 alpha by Western Blot.

All lanes:

Western blot - Anti-SDF1 antibody (ab25117)

All lanes:

Recombinant mouse SDF1 alpha

Predicted band size: 10 kDa

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关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Mouse, Rat

应用

IHC-Fr, IHC-FoFr, Flow Cyt, IP, IHC-P, WB

applications

免疫原

Recombinant Fragment Protein within Mouse Cxcl12 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.

P40224

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反应性数据

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产品详情

What is this antibody validated in?
Anti-SDF1 antibody (ab25117) is a rabbit polyclonal antibody and is validated for use in Western Blot (WB), Flow Cytometry (Flow Cyt), Immunoprecipitation (IP), Immunohistochemistry (IHC-P), Immunohistochemistry (IHC-Fr) in Mouse, Rat samples.

What is the molecular weight of SDF1?
Anti-SDF1 (ab25117) specifically detects a band for SDF1 (UniProt: P40224) at a molecular weight of 11kDa.

Trusted by the scientific community
Anti-SDF1 (ab25117) was first used in a scientific publication in 2006 and has been cited over 60 times in peer-reviewed journals.

Reviewed by scientists
Anti-SDF1 (ab25117) has over 5 independent reviews from customers.

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Protein A

存储溶液

pH: 6.5 Preservative: 0.1% Sodium azide Constituents: PBS

运输条件

Blue Ice

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

The stromal cell-derived factor 1 (SDF1) also known as C-X-C motif chemokine 12 (CXCL12) is a chemokine protein that is important in immunological responses and cellular signaling. This protein weighs approximately 8 kDa. SDF1 is largely expressed in bone marrow stroma liver and endothelium of various tissues positioning it as an integral player in cell migration and homing processes. The protein functions as a chemoattractant for lymphocytes promoting cellular trafficking and organ development.

Biological function summary

SDF1 influences the migration and survival of hematopoietic progenitor cells. It plays a pivotal role in heart development angiogenesis and neuronal protein regulation. SDF1 binds with high affinity to its receptor CXCR4 forming a critical signal transduction complex that modulates cellular movement and growth responses. This interaction is important in the regulation of cell positioning and potential pathways of pathological changes.

Pathways

SDF1 has an important role in the chemokine signaling pathway and is involved in the pathways controlling hematopoietic stem cell migration and homing. The interaction between SDF1 and CXCR4 triggers downstream signaling events engaging proteins like PI3K and MAPK which promote cell survival and proliferation. Furthermore the SDF1/CXCR4 axis is central to the vascular endothelial growth factor (VEGF) pathway facilitating angiogenesis and tissue repair mechanisms.

SDF1 relates closely to cancer metastasis and HIV infection. The SDF1/CXCR4 interaction acts as a co-receptor for HIV entry into host cells implicating it in viral pathogenesis. Overexpression of SDF1 and its binding partner CXCR4 contributes to tumor growth invasion and metastasis in various cancers by promoting angiogenesis and tumor cell migration. The targeting of the SDF1/CXCR4 axis holds therapeutic potential in cancer treatment and infectious disease management.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Chemoattractant active on T-lymphocytes and monocytes but not neutrophils (By similarity). Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis (By similarity). Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for CXCL12/SDF-1 (By similarity). Binds to the allosteric site (site 2) of integrins and activates integrins ITGAV : ITGB3, ITGA4 : ITGB1 and ITGA5 : ITGB1 in a CXCR4-independent manner (By similarity). Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase (By similarity). Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins (By similarity). CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase (By similarity). Plays a protective role after myocardial infarction (By similarity). Induces down-regulation and internalization of ACKR3 expressed in various cells (By similarity). Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation (PubMed : 8757135). Stimulates the proliferation of bone marrow-derived B-cell progenitors in the presence of IL7 as well as growth of stromal cell-dependent pre-B-cells (PubMed : 8134392).

See full target information Cxcl12

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文献 (71)

Recent publications for all applications. Explore the full list and refine your search

MedComm 6:e70344 PubMed40895187

2025

Global Lactylome Reveals Lactylation-Dependent Mechanisms Underlying CXC Motif Chemokine Ligand 12 Expression in Pulmonary Endothelium During Acute Respiratory Distress Syndrome.

Applications

Unspecified application

Species

Unspecified reactive species

Xu Liu,Haofei Wang,Weijie Ni,Xuecheng Dong,Mingzhu Zheng,Wei Chang

Scientific reports 15:14637 PubMed40287476

2025

Comprehensive single-cell transcriptome analysis of autologous platelet-rich plasma therapy on human thin endometrium.

Applications

Unspecified application

Species

Unspecified reactive species

Jie Zeng,Jingjing Quan,Haiying Liu,Wenyan Geng,Fuman Qiu,Jianqiao Liu

Cell reports. Medicine 6:102052 PubMed40239632

2025

Catalytic neural stem cell exosomes for multi-stage targeting and synergistical therapy of retinal ischemia-reperfusion injury.

Applications

Unspecified application

Species

Unspecified reactive species

Weiqiang Yang,Xiaojun Wang,Diwei Zheng,Jing Feng,Wenjun Kong,Yue Li,Guanghui Ma,Wei Wei,Yong Tao

Molecular cancer 24:64 PubMed40033380

2025

Distant origin of glioblastoma recurrence: neural stem cells in the subventricular zone serve as a source of tumor reconstruction after primary resection.

Applications

Unspecified application

Species

Unspecified reactive species

Xue Li,Hyun Jung Kim,Jihwan Yoo,Yeonhee Lee,Chang Hyun Nam,Jonghan Park,Soon-Tae Lee,Tae Min Kim,Seung Hong Choi,Jae-Kyung Won,Sung-Hye Park,Young Seok Ju,Jong Bae Park,Se Hoon Kim,Jong Hee Chang,Hong-Gyun Wu,Chul-Kee Park,Jeong Ho Lee,Seok-Gu Kang,Joo Ho Lee

Journal of cellular and molecular medicine 29:e70352 PubMed39855896

2025

Stromal Cell Derived Factor-1 Promotes Hepatic Insulin Resistance via Inhibiting Hepatocyte Lipophagy.

Applications

Unspecified application

Species

Unspecified reactive species

Chunfeng Lu,Yuting Zhang,Cuilian Sun,Yuhang Na,Haotian Sun,Jianhua Ma,Xueqin Wang,Xiaomin Cang

Journal of cellular and molecular medicine 28:e18397 PubMed38766687

2024

SAP deletion promotes malignant insulinoma progression by inducing CXCL12 secretion from CAFs via the CXCR4/p38/ERK signalling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Guangchun Jiang,Shuo Xu,Xiaobin Mai,Juan Tu,Le Wang,Lijing Wang,Yaping Zhan,Yan Wang,Qianqian Zhang,Lingyun Zheng,Jiangchao Li,Pei Tang,Cuiling Qi

PeerJ 11:e15894 PubMed37727693

2023

Tibial cortex transverse transport potentiates diabetic wound healing activation of SDF-1/CXCR4 signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Shuanji Ou,Xiaodong Wu,Yang Yang,Changliang Xia,Wei Zhang,Yudun Qu,Jiaxuan Li,Bo Chen,Lilin Zhu,Changpeng Xu,Yong Qi

Nature communications 14:2094 PubMed37055411

2023

Extracellular vesicles engineering by silicates-activated endothelial progenitor cells for myocardial infarction treatment in male mice.

Applications

Unspecified application

Species

Unspecified reactive species

Bin Yu,Hekai Li,Zhaowenbin Zhang,Peier Chen,Ling Wang,Xianglin Fan,Xiaodong Ning,Yuxuan Pan,Feiran Zhou,Xinyi Hu,Jiang Chang,Caiwen Ou

International journal of biological sciences 19:1791-1812 PubMed37063422

2023

M1 Microglia-derived Exosomes Promote Activation of Resting Microglia and Amplifies Proangiogenic Effects through Irf1/miR-155-5p/Socs1 Axis in the Retina.

Applications

Unspecified application

Species

Unspecified reactive species

Xi Chen,Xiao Wang,Zedu Cui,Qian Luo,Zihua Jiang,Yuke Huang,Jingyi Jiang,Jin Qiu,Yan Li,Keming Yu,Jing Zhuang

Frontiers in immunology 14:1114321 PubMed36911720

2023

Head and neck dermatitis is exacerbated by colonization, skin barrier disruption, and immune dysregulation.

Applications

Unspecified application

Species

Unspecified reactive species

Howard Chu,Su Min Kim,KeLun Zhang,Zhexue Wu,Hemin Lee,Ji Hye Kim,Hye Li Kim,Yu Ri Kim,Seo Hyeong Kim,Wan Jin Kim,Yang Won Lee,Kwang Hoon Lee,Kwang-Hyeon Liu,Chang Ook Park

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