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AB137639

Anti-SCYL1抗体

Anti-SCYL1 antibody

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(1 Publication)

Rabbit Polyclonal SCYL1 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SCYL1 aa 300 to C-terminus.

查看别名

CVAK90, GKLP, NTKL, TAPK, TEIF, TRAP, HT019, SCYL1, N-terminal kinase-like protein, Coated vesicle-associated kinase of 90 kDa, SCY1-like protein 1, Telomerase regulation-associated protein, Telomerase transcriptional element-interacting factor, Teratoma-associated tyrosine kinase

1 Images
Immunocytochemistry/ Immunofluorescence - Anti-SCYL1 antibody (AB137639)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-SCYL1 antibody (AB137639)

Confocal immunofluorescence analysis of paraformaldehyde fixed HeLa cells, labelling SCYL1 with ab137639 (Green) at 1/500 dilution. Alpha tubulin filaments were labelled with alpha tubulin antibody (Red) at 1/2500.

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

No

反应种属

Human

应用

ICC/IF, WB

applications

免疫原

Recombinant Fragment Protein within Human SCYL1 aa 300 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q96KG9

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替代产品

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AB95074

Anti-SCYL1 antibody

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搭配使用产品

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Proteins & Peptides

AB135221

Recombinant Human SCYL1 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human SCYL1 protein (AB135221)

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Primary Antibodies

AB156009

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Primary Antibodies

AB251766

Anti-CAMSAP2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CAMSAP2 antibody (AB251766)

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/100 - 1/1000", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Immunogen
存储溶液
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
运输条件
Blue Ice
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

SCYL1 also known as Scy1 Like Pseudokinase 1 is a pseudokinase with a molecular mass of approximately 95 kDa. It localizes primarily to the cytoplasm and is strongly expressed in the central nervous system liver and kidney. The protein possesses several phosphorylation sites and a characteristic N-terminal kinase-like domain although it lacks the typical catalytic activity of kinases. SCYL1 appears to be involved in cellular processes related to protein trafficking and stability.
Biological function summary

SCYL1 contributes to the sorting and transport of proteins between the Golgi apparatus and the endoplasmic reticulum. It interacts with coatomer complexes to facilitate vesicular trafficking ensuring proper cellular function and protein homeostasis. As part of the cellular transport machinery SCYL1 helps maintain the structural integrity of the Golgi complex and likely plays role in neurodevelopment due to its expression patterns and involvement in protein handling.

Pathways

SCYL1 influences the Golgi-to-ER transport pathways and is involved in vesicle formation and movement. It works alongside proteins like coatomer protein complex subunits to maintain efficient vesicular transport within the cell. Through these pathways SCYL1 connects to broader cellular functions like protein sorting and endosome-to-Golgi retrieval contributing to the systematic recycling and allocation of proteins across the cellular framework.

SCYL1 mutations link the protein to spinocerebellar ataxia type 21 and the hepatic disorder 3C syndrome. These conditions highlight the protein's connections to neurological and liver functions reflecting its significant role in these organs. Additionally interactions with proteins like TDP-43 suggest potential contributions to neurodegenerative processes when misregulated. Understanding SCYL1's role in these diseases provides insight into its importance for normal cellular functioning and the consequences of its dysfunction.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

Regulates COPI-mediated retrograde protein traffic at the interface between the Golgi apparatus and the endoplasmic reticulum (PubMed : 18556652). Involved in the maintenance of the Golgi apparatus morphology (PubMed : 26581903).. Isoform 6. Acts as a transcriptional activator. It binds to three different types of GC-rich DNA binding sites (box-A, -B and -C) in the beta-polymerase promoter region. It also binds to the TERT promoter region.
See full target information SCYL1
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

BMC cancer 21:841 PubMed34284744

2021

TRIM27 interacts with Iκbα to promote the growth of human renal cancer cells through regulating the NF-κB pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Chengwu Xiao,Wei Zhang,Meimian Hua,Huan Chen,Bin Yang,Ye Wang,Qing Yang
View all publications
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