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AB15093

Anti-SCP3 抗体

Anti-SCP3 antibody

5

(10 Reviews)

|

(211 Publications)

Anti-SCP3 antibody (ab15093) is a rabbit polyclonal antibody detecting SCP3 in ICC/IF. Suitable for Human, Mouse.

- Over 210 publications
- Trusted since 2004

查看别名

SCP3, SYCP3, Synaptonemal complex protein 3, SCP-3

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-SCP3 antibody (AB15093)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-SCP3 antibody (AB15093)

SCP3 labeled in mouse pachytene preparation (red), using ab15093. CDK2 staining, near teleomeres, is also present (green).

Immunocytochemistry/ Immunofluorescence - Anti-SCP3 antibody (AB15093)
  • ICC/IF

PubMed

Immunocytochemistry/ Immunofluorescence - Anti-SCP3 antibody (AB15093)

ab15093 staining SCP3 in pig spermatocytes by Immunocytochemistry/ Immunofluorescence. Cells were fixed with formaldehyde, permeabilized with Triton x100 and blocking with 0.15% BSA was performed for 30 minutes at 250C. Samples were incubated with primary antibody (1/100 : in PBT : PBS + 0.15% BSA+0.1% Tween 20) for 12 hours at 25°C. An Alexa Fluor®594-conjugated donkey polyclonal to rabbit IgG was used at dilution at 1/100 as secondary antibody.

This image is a courtesy of Anonymous Abreview

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

No

反应种属

Mouse, Human

应用

ICC/IF

applications

免疫原

Synthetic Peptide within Human SYCP3. The exact immunogen used to generate this antibody is proprietary information.

Q8IZU3

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "1/400", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Mouse": { "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "1/400", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>" } } }
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您是否考虑以下替代产品？

AB314313

Anti-SCP3 antibody [EPR27086-101]

0
0 Reviews
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为什么推荐这个？

为向您提供最高品质的产品，我们在不断升级产品范围。我们选择了这个替代产品供您参考，因为它提供了更好的性能，更容易和更方便的使用，或交期更快。

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产品详情

What is this antibody validated in?
Anti-SCP3 antibody (ab15093) is a rabbit polyclonal antibody and is validated for use in Immunocytochemistry/immunofluorescence (ICC/IF) in Human, Mouse samples.

Trusted by the scientific community
Anti-SCP3 (ab15093) was first used in a scientific publication in 2004 and has been cited over 210 times in peer-reviewed journals.

Reviewed by scientists
Anti-SCP3 (ab15093) has over 5 independent reviews from customers.
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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Immunogen
存储溶液
pH: 7.4 Preservative: 0.09% Sodium azide Constituents: PBS
运输条件
Blue Ice
推荐的短期储存条件
+4°C
推荐的长期储存条件
+4°C
储存信息
Do Not Freeze
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

The SCP3 protein also known as Synaptonemal complex protein 3 and COR1 plays an important role in cell division. It is a component of the synaptonemal complex which is essential during meiosis for chromosome pairing and recombination. SCP3 has a molecular mass of approximately 30 kDa. Researchers observe its expression in germline cells where it facilitates the accurate segregation of homologous chromosomes during the prophase I stage of meiosis.
Biological function summary

SCP3 serves an important function in organizing the scaffold of the synaptonemal complex a highly organized proteinaceous framework. This structure helps in stabilizing the pairing of homologous chromosomes and promoting synapsis. SCP3 does not work alone; it operates as part of a larger complex with other synaptonemal complex components including SCP1 and SCP2. This coordination ensures the successful exchange of genetic material between chromosomes enhancing genetic diversity in gametes.

Pathways

SCP3 integrates into the meiotic recombination process essential for gametogenesis. It aligns with the DNA repair pathway significantly impacting homologous recombination. Proteins like RAD51 and DMC1 are part of these pathways interacting indirectly with SCP3 to facilitate recombination repair processes. SCP3's role helps maintain genome integrity by ensuring faithful chromosome segregation which is critical in producing viable gametes.

SCP3 implicates reproductive issues and genetic schizophrenia predispositions. Abnormal or disrupted function of SCP3 often leads to infertility due to failed meiosis impacting gamete viability. This malfunction may associate with proteins like SPO11 which initiates meiotic recombination. Alterations in SCP3's function or expression have been studied for their potential connections to schizophrenia suggesting a role in neurological development related to errors during meiosis.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

Component of the synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Required for centromere pairing during meiosis in male germ cells (By similarity). Required for normal meiosis during spermatogenesis and male fertility (PubMed : 14643120). Plays a lesser role in female fertility. Required for efficient phosphorylation of HORMAD1 and HORMAD2 (By similarity).
See full target information SYCP3
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文献 (211)

Recent publications for all applications. Explore the full list and refine your search

Biology open 12: PubMed37819723

2023

Chromosomal organization of multigene families and meiotic analysis in species of Loricariidae (Siluriformes) from Brazilian Amazon, with description of a new cytotype for genus Spatuloricaria.

Applications

Unspecified application

Species

Unspecified reactive species

Bruno Rafael Ribeiro de Almeida,Luciano Farias Souza,Thyana Ayres Alves,Adauto Lima Cardoso,Juliana Amorim de Oliveira,Talita Fernanda Augusto Ribas,Carlos Eduardo Vasconcelos Dos Santos,Luís Adriano Santos do Nascimento,Leandro Melo Sousa,Maria Iracilda da Cunha Sampaio,Cesar Martins,Cleusa Yoshiko Nagamachi,Julio Cesar Pieczarka,Renata Coelho Rodrigues Noronha

eLife 12: PubMed37930936

2023

Genetic and karyotype divergence between parents affect clonality and sterility in hybrids.

Applications

Unspecified application

Species

Unspecified reactive species

Anatolie Marta,Tomáš Tichopád,Oldřich Bartoš,Jiří Klíma,Mujahid Ali Shah,Vendula Šlechtová Bohlen,Joerg Bohlen,Karel Halačka,Lukáš Choleva,Matthias Stöck,Dmitrij Dedukh,Karel Janko

Frontiers in endocrinology 14:1271724 PubMed38027210

2023

RNA sequencing profiles reveals progressively reduced spermatogenesis with progression in adult cryptorchidism.

Applications

Unspecified application

Species

Unspecified reactive species

Weihao Sun,Xinhui Zhang,Lei Wang,Guanyu Ren,Shuguang Piao,Chenghua Yang,Zhiyong Liu

Scientific reports 13:15502 PubMed37726346

2023

Robertsonian fusion triggers recombination suppression on sex chromosomes in Coleonyx geckos.

Applications

Unspecified application

Species

Unspecified reactive species

Artem Lisachov,Katerina Tishakova,Svetlana Romanenko,Lada Lisachova,Guzel Davletshina,Dmitry Prokopov,Lukáš Kratochvíl,Patricia O Brien,Malcolm Ferguson-Smith,Pavel Borodin,Vladimir Trifonov

Nature communications 14:5267 PubMed37644029

2023

The non-redundant functions of PIWI family proteins in gametogenesis in golden hamsters.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaolong Lv,Wen Xiao,Yana Lai,Zhaozhen Zhang,Hongdao Zhang,Chen Qiu,Li Hou,Qin Chen,Duanduan Wang,Yun Gao,Yuanyuan Song,Xinjia Shui,Qinghua Chen,Ruixin Qin,Shuang Liang,Wentao Zeng,Aimin Shi,Jianmin Li,Ligang Wu

Nature communications 14:4579 PubMed37516764

2023

Rapid gene content turnover on the germline-restricted chromosome in songbirds.

Applications

Unspecified application

Species

Unspecified reactive species

Stephen A Schlebusch,Jakub Rídl,Manon Poignet,Francisco J Ruiz-Ruano,Jiří Reif,Petr Pajer,Jan Pačes,Tomáš Albrecht,Alexander Suh,Radka Reifová

BioImpacts : BI 13:229-240 PubMed37431484

2023

Differentiation of human endometrial stem cells encapsulated in alginate hydrogel into oocyte-like cells.

Applications

Unspecified application

Species

Unspecified reactive species

Diba Ghasemi,Somayeh Ebrahimi-Barough,Mohammad Hossein Nekoofar,Abdolreza Mohamadnia,Nasrin Lotfibakhshaiesh,Naghmeh Bahrami,Roya Karimi,Vajihe Taghdiri Nooshabadi,Mahmoud Azami,Elham Hasanzadeh,Jafar Ai

Nature 619:394-402 PubMed37344600

2023

Relaxed targeting rules help PIWI proteins silence transposons.

Applications

Unspecified application

Species

Unspecified reactive species

Ildar Gainetdinov,Joel Vega-Badillo,Katharine Cecchini,Ayca Bagci,Cansu Colpan,Dipayan De,Shannon Bailey,Amena Arif,Pei-Hsuan Wu,Ian J MacRae,Phillip D Zamore

Genes 14: PubMed37239382

2023

Chromosome Asynapsis Is the Main Cause of Male Sterility in the Interspecies Hybrids of East Asian Voles (, Rodentia, Arvicolinae).

Applications

Unspecified application

Species

Unspecified reactive species

Tatiana Bikchurina,Marina Pavlenko,Elena Kizilova,Daria Rubtsova,Irina Sheremetyeva,Irina Kartavtseva,Anna Torgasheva,Pavel Borodin

Nature communications 14:2499 PubMed37120627

2023

Single-cell RNA-seq uncovers dynamic processes orchestrated by RNA-binding protein DDX43 in chromatin remodeling during spermiogenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Huanhuan Tan,Weixu Wang,Congjin Zhou,Yanfeng Wang,Shu Zhang,Pinglan Yang,Rui Guo,Wei Chen,Jinwen Zhang,Lan Ye,Yiqiang Cui,Ting Ni,Ke Zheng
View all publications
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Abcam Product Promise

我们致力于为您的研究提供高质量的试剂，为您科研的每一步提供支持。若我们的产品未能达到预期性能，我们向您提供 Abcam Product Promise 保障。
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