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AB111871

Anti-SCGN/Secretagogin 抗体

Anti-SCGN/Secretagogin antibody

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(4 Publications)

Rabbit Polyclonal SCGN/Secretagogin antibody. Suitable for IHC-Fr, WB, ICC/IF and reacts with Mouse, Human, Rat samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human SCGN aa 50-250.

查看别名

SECRET, SCGN, Secretagogin

4 Images
Immunohistochemistry (Frozen sections) - Anti-SCGN/Secretagogin antibody (AB111871)
  • IHC-Fr

Supplier Data

Immunohistochemistry (Frozen sections) - Anti-SCGN/Secretagogin antibody (AB111871)

Immunohistochemical analysis of frozen sectioned adult mouse retina tissue labeling SCGN with ab111871 at 1/250 dilution.

beta Tubulin 3/ TUJ1, a mature neuron marker, stained by beta Tubulin 3/ TUJ1 antibody at a 1/250 dilution. DAPI was used for nuclear staining.

Immunocytochemistry/ Immunofluorescence - Anti-SCGN/Secretagogin antibody (AB111871)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-SCGN/Secretagogin antibody (AB111871)

Immunofluorescence analysis of DIV9 rat E18 primary cortical neuron cells fixed in 4% paraformaldehyde at RT for 15 min labelling SCGN protein using ab111871 at a 1/500 dilution (Green).
beta Tubulin 3/ Tuj1, stained by beta Tubulin 3/ Tuj1 antibody at a 1/500 dilution (Red). Hoechst 33342 was used for nuclear staining (Blue).

Immunohistochemistry (Frozen sections) - Anti-SCGN/Secretagogin antibody (AB111871)
  • IHC-Fr

Supplier Data

Immunohistochemistry (Frozen sections) - Anti-SCGN/Secretagogin antibody (AB111871)

Immunohistochemical analysis of frozen sectioned adult mouse cerebellum tissue labeling SCGN with ab111871 at 1/250 dilution.

NF-H, stained by NF-H antibody at a 1/500 dilution. DAPI was used for nuclear staining.
Antigen Retrieval : Citrate buffer, pH 6.0, 10 min

Western blot - Anti-SCGN/Secretagogin antibody (AB111871)
  • WB

Unknown

Western blot - Anti-SCGN/Secretagogin antibody (AB111871)

12% SDS PAGE

All lanes:

Western blot - Anti-SCGN/Secretagogin antibody (ab111871) at 1/1000 dilution

All lanes:

HeLa whole cell lysate at 30 µg

Predicted band size: 32 kDa,44 kDa

false

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

No

反应种属

Mouse, Rat, Human

应用

IHC-Fr, ICC/IF, WB

applications

免疫原

Recombinant Fragment Protein within Human SCGN aa 50-250. The exact immunogen used to generate this antibody is proprietary information.

O76038

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替代产品

Primary Antibodies

AB244219

Anti-SCGN/Secretagogin antibody [CL0271]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SCGN/Secretagogin antibody [CL0271] (AB244219)

  • 0
  • 0
Primary Antibodies

AB137017

Anti-SCGN/Secretagogin antibody [EPR7477]

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SCGN/Secretagogin antibody [EPR7477] (AB137017)

  • 5
  • 1
Primary Antibodies

AB138493

Anti-SCGN/Secretagogin antibody [EPR7476]

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SCGN/Secretagogin antibody [EPR7476] (AB138493)

  • 0
  • 0
Primary Antibodies

AB211362

Anti-SCGN/Secretagogin antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SCGN/Secretagogin antibody (AB211362)

  • 0
  • 0

搭配使用产品

Primary Antibodies

AB110641

Anti-BRG1 antibody [EPNCIR111A]

20ul selling size|BOND RX™ Validated|Recombinant|KO Validated|Advanced Validation|RabMAb

ChIC/CUT&RUN sequencing - Anti-BRG1 antibody [EPNCIR111A] (AB110641)

  • 5
  • 10
Primary Antibodies

AB52623

Anti-beta III Tubulin antibody [EP1569Y] - Neuronal Marker

BOND RX™ Validated|KO Validated|RabMAb|Advanced Validation|Recombinant|Lab Essentials|20ul selling size

Immunocytochemistry/ Immunofluorescence - Anti-beta III Tubulin antibody [EP1569Y] - Neuronal Marker (AB52623)

  • 5
  • 6
Primary Antibodies

AB152101

Anti-RBPMS antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RBPMS antibody (AB152101)

  • 4
  • 3
Primary Antibodies

AB32072

Anti-c-Myc antibody [Y69] - ChIP Grade

BOND RX™ Validated|KO Validated|RabMAb|Recombinant|Lab Essentials|20ul selling size|Advanced Validation

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-c-Myc antibody [Y69] - ChIP Grade (AB32072)

  • 4
  • 56
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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCFr" : {"fullname" : "Immunohistochemistry (Frozen sections)", "shortname":"IHC-Fr"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCFr-species-checked": "guaranteed", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Mouse": { "IHCFr-species-checked": "testedAndGuaranteed", "IHCFr-species-dilution-info": "1/100 - 1/1000", "IHCFr-species-notes": "<p></p>", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "IHCFr-species-checked": "guaranteed", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/100 - 1/1000", "ICCIF-species-notes": "<p></p>" }, "Cow": { "IHCFr-species-checked": "predicted", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Immunogen
纯化说明
ab111871 is purified by antigen-affinity chromatography.
存储溶液
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: PBS, 20% Glycerol (glycerin, glycerine), 1% BSA
运输条件
Blue Ice
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

SCGN also known as Secretagogin is a calcium-binding protein with a molecular weight of approximately 33 kDa. It belongs to the family of EF-hand superfamily proteins which is known for its role in various cellular processes. Secretagogin predominantly expresses in neuroendocrine tissues such as the pancreas and central nervous system where it binds calcium and possibly modulates its signaling. It has drawn interest due to its distinctive expression pattern and potential role in regulated secretion.
Biological function summary

The role of Secretagogin extends beyond simple calcium binding. It participates in managing cytoskeleton dynamics through its ability to bind calcium impacting processes like vesicle trafficking. Although not part of a standard protein complex Secretagogin interacts with other cytoskeletal proteins and may influence the release of hormones. Its role in neurotransmission and insulin secretion showcases its significance in both the nervous and endocrine systems.

Pathways

Secretagogin interacts within signaling networks such as the calcium-signaling and insulin-secretion pathways. It has established relationships with other proteins like actin influencing cellular architecture and trafficking. Through these pathways Secretagogin appears instrumental in processes involving rapid response times such as neurotransmitter release or hormone secretion often acting in conjunction with or supporting other calcium-binding proteins.

Secretagogin has connections to diabetes and certain neuroendocrine tumors. Its involvement in insulin secretion makes it relevant in the context of diabetes where it might interact with malfunctioning insulin-related proteins. Additionally in neuroendocrine tumors altered Secretagogin expression could be linked with oncogenic processes as it shares pathways with proteins involved in cell-cycle regulation. Understanding these associations can aid in identifying potential therapeutic targets or biomarkers for these diseases.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

See full target information SCGN
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文献 (4)

Recent publications for all applications. Explore the full list and refine your search

Journal of neuroendocrinology 34:e13109 PubMed35304807

2022

Combined use of Lu-DOTATATE peptide receptor radionuclide therapy and fluzoparib for treatment of well-differentiated neuroendocrine tumors: A preclinical study.

Applications

Unspecified application

Species

Unspecified reactive species

Jingjing Fu,Fan Qiu,Cati Raluca Stolniceanu,Fei Yu,Shiming Zang,Yili Xiang,Yue Huang,Milovan Matovic,Cipriana Stefanescu,Qiyun Tang,Feng Wang

Science (New York, N.Y.) 374:eabj6641 PubMed34882453

2021

Mouse and human share conserved transcriptional programs for interneuron development.

Applications

Unspecified application

Species

Unspecified reactive species

Yingchao Shi,Mengdi Wang,Da Mi,Tian Lu,Bosong Wang,Hao Dong,Suijuan Zhong,Youqiao Chen,Le Sun,Xin Zhou,Qiang Ma,Zeyuan Liu,Wei Wang,Junjing Zhang,Qian Wu,Oscar Marín,Xiaoqun Wang

The Journal of comparative neurology 526:877-898 PubMed29218729

2017

Structural and molecular heterogeneity of calretinin-expressing interneurons in the rodent and primate striatum.

Applications

Unspecified application

Species

Mouse

Farid N Garas,Eszter Kormann,Rahul S Shah,Federica Vinciati,Yoland Smith,Peter J Magill,Andrew Sharott

eLife 5: PubMed27669410

2016

Secretagogin expression delineates functionally-specialized populations of striatal parvalbumin-containing interneurons.

Applications

Unspecified application

Species

Unspecified reactive species

Farid N Garas,Rahul S Shah,Eszter Kormann,Natalie M Doig,Federica Vinciati,Kouichi C Nakamura,Matthijs C Dorst,Yoland Smith,Peter J Magill,Andrew Sharott
View all publications
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