AB90238

Anti-SCGF抗体[MM0533-6D5]

Name: SCGF抗体[MM0533-6D5] (ab90238)| Abcam中文官网
Brand: Abcam Limited
SKU: AB90238
Price: 4606 CNY
Availability: InStock

Anti-SCGF antibody [MM0533-6D5]

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(2 Publications)

Mouse Monoclonal SCGF antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human CLEC11A.

查看别名

CLECSF3, LSLCL, SCGF, CLEC11A, C-type lectin domain family 11 member A, C-type lectin superfamily member 3, Lymphocyte secreted C-type lectin, Osteolectin, Stem cell growth factor, p47

1 Images

Supplier Data

Western blot - Anti-SCGF antibody [MM0533-6D5] (AB90238)

All lanes:

Western blot - Anti-SCGF antibody [MM0533-6D5] (ab90238) at 1/500 dilution

All lanes:

Human placenta tissue lysate

Predicted band size: 35 kDa

false

关键信息

宿主种属

Mouse

克隆

Monoclonal

克隆号

MM0533-6D5

亚型

IgG1

不含载体蛋白

反应种属

Human

应用

WB, IHC-P

applications

免疫原

Recombinant Full Length Protein corresponding to Human CLEC11A.

Q9Y240

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Protein G

存储溶液

Constituents: PBS

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Stem Cell Growth Factor (SCGF) also known as C-type lectin domain family 11 member A (CLEC11A) is a glycoprotein with a mass around 38 kDa. It mechanically functions by promoting mitogenic and survival activities on hematopoietic progenitors which are essential for blood cell formation. SCGF is mainly expressed in the bone marrow as well as in several other tissues such as the pancreas and liver where it plays significant roles.

Biological function summary

SCGF plays a significant role in the development and regulation of the hematopoietic system. It supports the proliferation and differentiation of a variety of blood cell lineages. SCGF does not belong to a complex but interacts with other soluble factors like cytokines and growth factors to exert its functions. It enhances the actions of colony-stimulating factors emphasizing its role in hematopoiesis.

Pathways

SCGF is important in the regulation of the hematopoietic growth pathways. It is involved in the cytokine-cytokine receptor interaction pathway which assists in signaling and communication between cells. SCGF shows interactions with proteins like FLT3 which play a role in the development and survival of blood cell precursors. This intricate network bolsters the adaptive and innate immune systems by promoting the production and function of necessary blood cells.

Disruptions in SCGF activity can influence both hematological and autoimmune disorders. Alterations in SCGF expression have connections to leukemia where abnormal proliferation of blood cells occurs. Additionally its dysregulation may contribute to autoimmune diseases where the immune system mistakenly attacks the body. In these contexts SCGF relates with the cytokine IL-6 which is also involved in immune responses and inflammation further underlining SCGF's influence on disease mechanisms.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Promotes osteogenesis by stimulating the differentiation of mesenchymal progenitors into mature osteoblasts (PubMed : 27976999). Important for repair and maintenance of adult bone (By similarity).

See full target information CLEC11A

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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Genes 13: PubMed35456465

2022

Transcriptome Profile of Membrane and Extracellular Matrix Components in Ligament-Fibroblastic Progenitors and Cementoblasts Differentiated from Human Periodontal Ligament Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Seyoung Mun,Seong Min Kim,Min-Jeong Choi,Young-Joo Jang

Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons 75:298-308 PubMed27546031

2016

Genetic Analysis of Giant Cell Lesions of the Maxillofacial and Axial/Appendicular Skeletons.

Applications

Unspecified application

Species

Unspecified reactive species

Zachary S Peacock,Joseph H Schwab,William C Faquin,Francis J Hornicek,Yair Benita,David H Ebb,Leonard B Kaban

View all publications

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Anti-SCGF抗体[MM0533-6D5]

Anti-SCGF antibody [MM0533-6D5]

Western blot - Anti-SCGF antibody [MM0533-6D5] (AB90238)

关键信息

宿主种属

克隆

克隆号

亚型

不含载体蛋白

反应种属

应用

免疫原