AB34735

Anti-SATB2 抗体

Name: SATB2抗体 (ab34735)| Abcam中文官网
Brand: Abcam Limited
SKU: AB34735
Price: 4513 CNY
Availability: InStock
Rating: 5 (2 reviews)

Anti-SATB2 antibody

(2 Reviews)

(112 Publications)

Anti-SATB2 antibody (ab34735) is a rabbit polyclonal antibody detecting SATB2 in Western Blot. Suitable for Mouse.

- Over 90 publications
- Trusted since 2007

查看别名

Kiaa1034, Satb2, DNA-binding protein SATB2, Special AT-rich sequence-binding protein 2

1 Images

Project2358****

Western blot - Anti-SATB2 antibody (AB34735)

All lanes:

Western blot - Anti-SATB2 antibody (ab34735) at 1 µg/mL

All lanes:

Western blot - Mouse brain tissue lysate - total protein (0 days) (<a href='/products/tissue-lysates/mouse-brain-tissue-lysate-total-protein-0-days-ab7188'>ab7188</a>) at 10 µg

Secondary

All lanes:

IRDye 680 Conjugated Goat Anti-Rabbit IgG (H+L) at 1/15000 dilution

Predicted band size: 83 kDa

Observed band size: 30 kDa,85 kDa

false

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Mouse

应用

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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反应性数据

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产品详情

What is this antibody validated in?
Anti-SATB2 antibody (ab34735) is a rabbit polyclonal antibody and is validated for use in Western Blot (WB) in Mouse samples.

What is the molecular weight of SATB2?
Anti-SATB2 (ab34735) specifically detects a band for SATB2 (UniProt: Q9UPW6) at a molecular weight of 83kDa.

Trusted by the scientific community
Anti-SATB2 (ab34735) was first used in a scientific publication in 2007 and has been cited over 90 times in peer-reviewed journals.

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

存储溶液

pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 1% BSA

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

The SATB2 protein also known as Special AT-rich Sequence-Binding Protein 2 is a DNA-binding protein with a mass of about 82 kDa. It plays a role in chromatin organization and transcriptional regulation by binding to AT-rich sequences within the nuclear matrix. SATB2 shows high expression levels in the cerebral cortex and the bone where it influences gene expression. It functions by facilitating the assembly of transcriptional machineries enhancing or repressing the transcription of its target genes.

Biological function summary

SATB2 acts as a regulator of multiple developmental processes. It serves as a master control gene in osteoblast differentiation and skeletal development by forming complexes with core binding factors. In the brain SATB2 contributes to the development and maintenance of neuronal networks that are essential for cognitive functions. Its binding to matrix attachment regions aids in the spatial organization of nuclear chromatin impacting gene expression pertinent to development and differentiation.

Pathways

SATB2 operates within the Wnt signaling pathway and the regulation of osteoblast differentiation. It interacts with proteins such as RUNX2 and Β-catenin which play roles in bone formation and homeostasis. Within these pathways SATB2 modulates gene networks that influence the expression of structural and signaling proteins important for tissue differentiation and repair particularly in bone and neuronal contexts.

SATB2 has associations with cleft palate and intellectual disabilities conditions often related to alterations in craniofacial and neurological development. It interacts with proteins like SOX9 and TCF7L1 which have roles in developmental processes that when disrupted can lead to such conditions. Understanding SATB2's involvement in these disorders provides insights into potential therapeutic targets for interventions aiming to mitigate developmental abnormalities.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Binds to DNA, at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes, probably by modulating Bcl11b expression. Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex. May play an important role in palate formation. Acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation.

See full target information Satb2

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文献 (112)

Recent publications for all applications. Explore the full list and refine your search

Nature neuroscience 28:2022-2033 PubMed40826298

2025

FOXP genes regulate Purkinje cell diversity and cerebellar morphogenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Nagham Khouri-Farah,Qiuxia Guo,Thomas A Perry,Ryan Dussault,James Y H Li

Nature communications 16:6659 PubMed40683857

2025

Prdm16 regulates the postnatal fate of embryonic radial glia via Vcam1-dependent mechanisms.

Applications

Unspecified application

Species

Unspecified reactive species

Jiwen Li,Marlesa I Godoy,Yi Lu,Alice J Zhang,Graciel Diamante,Elle Rathbun,Min Tian,In Sook Ahn,Arantxa Cebrian-Silla,Arturo Alvarez-Buylla,Xia Yang,Bennett G Novitch,S Thomas Carmichael,Ye Zhang

Health science reports 8:e71056 PubMed40636538

2025

Elevated Methylation Contributes to Suppressed Expression of Special AT-Rich Sequence-Binding Protein 2 in Colorectal Cancer: A Gene-Disease Association Study.

Applications

Unspecified application

Species

Unspecified reactive species

Weitong Cui,Cong Lu,Huaru Xue,Lei Wei,Shuai Li,Lianzheng Su,Dianfang Wei,Xiaoyu Feng,Kai Wang,Chao Song

Toxicology research 14:tfaf047 PubMed40177383

2025

Astragaloside IV inhibits nasopharyngeal carcinoma progression by suppressing the SATB2/Wnt signaling axis.

Applications

Unspecified application

Species

Unspecified reactive species

Yinping Zeng,Tingting Duan,Jiajun Huang,Xiaofeng Wang

Nature communications 16:2845 PubMed40122897

2025

Astrocyte-secreted cues promote neural maturation and augment activity in human forebrain organoids.

Applications

Unspecified application

Species

Unspecified reactive species

Honghui Zheng,Yilin Feng,Jiyuan Tang,Feifei Yu,Zitian Wang,Jiani Xu,Cheng Hai,Mingyue Jiang,Yifan Cheng,Zhicheng Shao,Ning Ma,Peter E Lobie,Shaohua Ma

Nature 638:172-181 PubMed39743596

2025

Dysregulation of mTOR signalling is a converging mechanism in lissencephaly.

Applications

Unspecified application

Species

Unspecified reactive species

Ce Zhang,Dan Liang,A Gulhan Ercan-Sencicek,Aybike S Bulut,Joelly Cortes,Iris Q Cheng,Octavian Henegariu,Sayoko Nishimura,Xinyuan Wang,A Buket Peksen,Yutaka Takeo,Caner Caglar,TuKiet T Lam,Merve Nur Koroglu,Anand Narayanan,Francesc Lopez-Giraldez,Danielle F Miyagishima,Ketu Mishra-Gorur,Tanyeri Barak,Katsuhito Yasuno,E Zeynep Erson-Omay,Cengiz Yalcinkaya,Guilin Wang,Shrikant Mane,Hande Kaymakcalan,Aslan Guzel,A Okay Caglayan,Beyhan Tuysuz,Nenad Sestan,Murat Gunel,Angeliki Louvi,Kaya Bilguvar

Neuron 112:3602-3617.e9 PubMed39406239

2024

Synaptic neoteny of human cortical neurons requires species-specific balancing of SRGAP2-SYNGAP1 cross-inhibition.

Applications

Unspecified application

Species

Unspecified reactive species

Baptiste Libé-Philippot,Ryohei Iwata,Aleksandra J Recupero,Keimpe Wierda,Sergio Bernal Garcia,Luke Hammond,Anja van Benthem,Ridha Limame,Martyna Ditkowska,Sofie Beckers,Vaiva Gaspariunaite,Eugénie Peze-Heidsieck,Daan Remans,Cécile Charrier,Tom Theys,Franck Polleux,Pierre Vanderhaeghen

Materials today. Bio 28:101250 PubMed39318371

2024

An injectable decellularized extracellular matrix hydrogel with cortical neuron-derived exosomes enhances tissue repair following traumatic spinal cord injury.

Applications

Unspecified application

Species

Unspecified reactive species

Gang Wang,Qian Li,Sumei Liu,Mo Li,Baoguo Liu,Tianyao Zhao,Bochao Liu,Zhiguo Chen

Neuron 112:3058-3068.e8 PubMed39111306

2024

SYNGAP1 deficiency disrupts synaptic neoteny in xenotransplanted human cortical neurons in vivo.

Applications

Unspecified application

Species

Unspecified reactive species

Ben Vermaercke,Ryohei Iwata,Keimpe Wierda,Leïla Boubakar,Paula Rodriguez,Martyna Ditkowska,Vincent Bonin,Pierre Vanderhaeghen

Neuron 112:2765-2782.e9 PubMed38917805

2024

Individual thalamic inhibitory interneurons are functionally specialized toward distinct visual features.

Applications

Unspecified application

Species

Unspecified reactive species

Fiona E Müllner,Botond Roska

View all publications

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