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AB221488

Anti-SARA抗体

Anti-SARA antibody

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(1 Publication)

Rabbit Polyclonal SARA antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ZFYVE9 aa 400 to C-terminus.

查看别名

MADHIP, SARA, SMADIP, ZFYVE9, Zinc finger FYVE domain-containing protein 9, Mothers against decapentaplegic homolog-interacting protein, Novel serine protease, Receptor activation anchor, Smad anchor for receptor activation, Madh-interacting protein, NSP, hSARA

1 Images
Immunocytochemistry/ Immunofluorescence - Anti-SARA antibody (AB221488)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-SARA antibody (AB221488)

Immunofluorescent analysis of PFA-fixed/Triton X-100 permeabilized RT4 cells labeling SARA with ab221488 at 4 μg/ml (green).

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

No

反应种属

Human

应用

ICC/IF

applications

免疫原

Recombinant Fragment Protein within Human ZFYVE9 aa 400 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

O95405

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替代产品

Primary Antibodies

AB124875

Anti-SARA antibody [EPR5020]

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SARA antibody [EPR5020] (AB124875)

  • 0
  • 0

搭配使用产品

Primary Antibodies

AB235578

Anti-TGF beta Receptor I antibody [EPR20923-13]

20ul selling size|RabMAb|Recombinant|KO Validated

Western blot - Anti-TGF beta Receptor I antibody [EPR20923-13] (AB235578)

  • 0
  • 0
Primary Antibodies

AB215715

Anti-TGF beta 1 antibody [EPR21143]

20ul selling size|BOND RX™ Validated|RabMAb|Recombinant|KO Validated

Western blot - Anti-TGF beta 1 antibody [EPR21143] (AB215715)

  • 5
  • 7
Primary Antibodies

AB181125

Anti-STING antibody [EPR13130]

20ul selling size|KO Validated|RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-STING antibody [EPR13130] (AB181125)

  • 4
  • 1
Primary Antibodies

AB302617

Anti-cGAS antibody [EPR26492-84]

20ul selling size|RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-cGAS antibody [EPR26492-84] (AB302617)

  • 0
  • 0
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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" } } }
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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Immunogen
存储溶液
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

SARA also known as Smad anchor for receptor activation plays an important mechanical role in cellular signaling. It functions by binding to phosphorylated receptor-regulated Smad proteins (R-Smads) and facilitating their movement and accumulation in the nucleus. SARA has a molecular mass of approximately 150 kDa and is prominently expressed in a variety of tissues including the brain liver and kidney indicating a widespread functional role in physiological processes.
Biological function summary

SARA engages in interactions with several signaling molecules in the cell. It acts as a scaffolding protein that forms part of a complex with the Smad proteins assisting in the regulation of transforming growth factor-beta (TGF-β) signaling. By serving as a critical link between membranes and the cytoplasm it ensures the accurate transmission of signals necessary for cellular responses. Its location and function highlight its vital role in maintaining cellular homeostasis.

Pathways

SARA plays an important role in TGF-β and bone morphogenetic protein (BMP) signaling pathways. These pathways are essential for regulating cellular processes such as proliferation differentiation and apoptosis. SARA interacts with Smad2 Smad3 and Smad7 which are key components of these pathways. Through these interactions SARA helps mediate the transduction of signals that guide complex cellular activities and responses linking external signals to gene expression inside the nucleus.

Research has linked SARA to cancer and fibrotic diseases. Its role in TGF-β signaling suggests that alterations in SARA expression or function can contribute to tumor progression and metastatic processes. Additionally in fibrotic diseases where excess tissue scarring occurs the modulation of the pathway by proteins like Smad2 and Smad3 with SARA's involvement can result in aberrant tissue responses. Understanding SARA's involvement in these conditions may offer potential therapeutic insights.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

Early endosomal protein that functions to recruit SMAD2/SMAD3 to intracellular membranes and to the TGF-beta receptor. Plays a significant role in TGF-mediated signaling by regulating the subcellular location of SMAD2 and SMAD3 and modulating the transcriptional activity of the SMAD3/SMAD4 complex. Possibly associated with TGF-beta receptor internalization.
See full target information ZFYVE9
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Vaccines 8: PubMed32046307

2020

A Novel Combined Scientific and Artistic Approach for the Advanced Characterization of Interactomes: The Akirin/Subolesin Model.

Applications

Unspecified application

Species

Unspecified reactive species

Sara Artigas-Jerónimo,Juan J Pastor Comín,Margarita Villar,Marinela Contreras,Pilar Alberdi,Israel León Viera,Leandro Soto,Raúl Cordero,James J Valdés,Alejandro Cabezas-Cruz,Agustín Estrada-Peña,José de la Fuente
View all publications
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