AB232928

Anti-Salusin alpha抗体

Name: Salusin alpha抗体 (ab232928)| Abcam中文官网
Brand: Abcam Limited
SKU: AB232928
Price: 4908 CNY
Availability: InStock

Anti-Salusin alpha antibody

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(3 Publications)

Rabbit Polyclonal Salusin alpha antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Mouse Torsin-2A aa 100 to C-terminus.

查看别名

Torsin-2A, Torsin family 2 member A, Tor2a

7 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Salusin alpha antibody (AB232928)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Salusin alpha antibody (AB232928)

Formalin-fixed, paraffin-embedded mouse skin tissue stained for Salusin alpha using ab232928 at 10 μg/ml in immunohistochemical analysis. DAB staining.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Salusin alpha antibody (AB232928)

Paraffin-embedded mouse cardiac muscle tissue stained for Salusin alpha using ab232928 at 10 μg/ml in immunohistochemical analysis. DAB staining.

Supplier Data

Western blot - Anti-Salusin alpha antibody (AB232928)

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Western blot - Anti-Salusin alpha antibody (ab232928) at 1 µg/mL

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Mouse serum

Secondary

All lanes:

HRP-Linked Goat anti-Rabbit IgG polyclonal at 0.2 µg/mL

Predicted band size: 36 kDa

false

Supplier Data

Western blot - Anti-Salusin alpha antibody (AB232928)

All lanes:

Western blot - Anti-Salusin alpha antibody (ab232928) at 1 µg/mL

All lanes:

Mouse heart lysate

Secondary

All lanes:

HRP-Linked Goat anti-Rabbit IgG polyclonal at 0.2 µg/mL

Predicted band size: 36 kDa

false

Supplier Data

Western blot - Anti-Salusin alpha antibody (AB232928)

All lanes:

Western blot - Anti-Salusin alpha antibody (ab232928) at 2 µg/mL

All lanes:

Recombinant mouse Salusin alpha protein

Predicted band size: 36 kDa

false

Supplier Data

Western blot - Anti-Salusin alpha antibody (AB232928)

All lanes:

Western blot - Anti-Salusin alpha antibody (ab232928) at 1 µg/mL

All lanes:

Mouse liver lysate

Secondary

All lanes:

HRP-Linked Goat anti-Rabbit IgG polyclonal at 0.2 µg/mL

Predicted band size: 36 kDa

false

Supplier Data

Western blot - Anti-Salusin alpha antibody (AB232928)

All lanes:

Western blot - Anti-Salusin alpha antibody (ab232928) at 1 µg/mL

All lanes:

HeLa (human epithelial cell line from cervix adenocarcinoma) cell lysate

Secondary

All lanes:

HRP-Linked Goat anti-Rabbit IgG polyclonal at 0.2 µg/mL

Predicted band size: 36 kDa

false

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Mouse, Human

应用

WB, IHC-P

applications

免疫原

Recombinant Fragment Protein within Mouse Torsin-2A aa 100 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q8R1J9

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-20 µg/mL", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

纯化说明

ab232928 was purified by antigen-specific affinity chromatography followed by Protein A affinity chromatography.

存储溶液

pH: 7.4 Preservative: 0.011% Proclin 300 Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Salusin alpha also known as SAL-A is a bioactive peptide with a molecular weight of approximately 28 amino acids. It derives from the same precursor as salusin beta. Its primary activity involves interaction with various receptors influencing cardiovascular and metabolic processes. This peptide is expressed in multiple tissues including the adrenal glands kidney and central nervous system. In cells it can be secreted to exert effects in autocrine and paracrine signaling.

Biological function summary

Salusin alpha contributes significantly to the regulation of blood pressure and lipid metabolism. Although not part of a large protein complex it operates independently to impact these processes. Its presence in vascular tissues points to a role in vasodilation aiding in the modulation of vascular tone. It also influences cholesterol uptake and storage presenting potential implications for metabolic health.

Pathways

Salusin alpha plays a role in the renin-angiotensin system and in lipid metabolism. In the renin-angiotensin system it modulates blood pressure by affecting renal function and vascular resistance. Additionally in lipid metabolism its interactions with proteins such as leptin help regulate energy storage and expenditure. These pathways indicate its versatility in maintaining cardiovascular and metabolic stability.

Salusin alpha shows particular relevance to hypertension and atherosclerosis. Its regulatory effect on blood pressure links it closely to hypertension while its role in lipid metabolism ties it to atherosclerosis. These conditions involve proteins such as angiotensin and LDL receptors which influence the development and progression of cardiovascular diseases. Understanding salusin alpha's activity may offer insights into therapeutic opportunities for these common health challenges.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

See full target information Torsin-2A

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文献 (3)

Recent publications for all applications. Explore the full list and refine your search

Folia histochemica et cytobiologica 63:11-27 PubMed40152123

2025

Inhibition of STAT1 alleviates oxidative damage in retinal pigment epithelial cells and exhibits neuroprotective effects in autoimmune optic neuritis by upregulating IFI30 lysosomal thiol reductase.

Applications

Unspecified application

Species

Unspecified reactive species

Siqi Ma,Jiajia Yuan

International journal of molecular medicine 54: PubMed38963051

2024

Salusin‑α alleviates lipid metabolism disorders via regulation of the downstream lipogenesis genes through the LKB1/AMPK pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Jintong Pan,Chao Yang,Aohong Xu,Huan Zhang,Ye Fan,Rong Zeng,Lin Chen,Xiang Liu,Yuxue Wang

International journal of molecular medicine 51: PubMed37026514

2023

Overexpression of salusin‑α upregulates AdipoR2 and activates the PPARα/ApoA5/SREBP‑1c pathway to inhibit lipid synthesis in HepG2 cells.

Applications

Unspecified application

Species

Unspecified reactive species

Huan Zhang,Chao Yang,Songjiao Wang,Aohong Xu,Qian Zhang,Xiuqun Duan,Guofu Gong,Yuxue Wang

View all publications

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Anti-Salusin alpha抗体

Anti-Salusin alpha antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Salusin alpha antibody (AB232928)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Salusin alpha antibody (AB232928)

Western blot - Anti-Salusin alpha antibody (AB232928)

Western blot - Anti-Salusin alpha antibody (AB232928)

Western blot - Anti-Salusin alpha antibody (AB232928)

Western blot - Anti-Salusin alpha antibody (AB232928)

Western blot - Anti-Salusin alpha antibody (AB232928)