Anti-SALL1抗体[K9814] (ab41974)
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SALL1 antibody [K9814] (ab41974)](https://www.abcam.cn/ps/products/41/ab41974/Images/ab41974-281677-anti-sall1-antibody-k9814-immunohistochemistry.jpg "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SALL1 antibody [K9814] (ab41974)")
Key features and details
- Mouse monoclonal [K9814] to SALL1
- Suitable for: IHC-P
- Reacts with: Mouse
- Isotype: IgG2a
概述
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产品名称
Anti-SALL1抗体[K9814]
参阅全部 SALL1 一抗 -
描述
小鼠单克隆抗体[K9814] to SALL1 -
宿主
Mouse -
经测试应用
适用于: IHC-Pmore details -
种属反应性
与反应: Mouse -
免疫原
Baculovirus-expressed recombinant fragment, corresponding to amino acids 258/499 of Human SALL1
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常规说明
This product was changed from ascites to tissue culture supernatant on 3rd April 2019. Please note that the dilutions may need to be adjusted accordingly. If you have any questions, please do not hesitate to contact our scientific support team.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
存储溶液
pH: 7
Preservative: 0.1% Sodium azide
Constituent: PBS -
Concentration information loading... -
纯度
Tissue culture supernatant -
克隆
单克隆 -
克隆编号
K9814 -
骨髓瘤
NS1 -
同种型
IgG2a -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab41974于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| IHC-P | (1) |
Use at an assay dependent concentration.
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| 说明 |
|---|
|
IHC-P
Use at an assay dependent concentration. |
靶标
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功能
Transcriptional repressor involved in organogenesis. -
组织特异性
Highest levels in kidney. Lower levels in adult brain (enriched in corpus callosum, lower expression in substantia nigra) and liver. -
疾病相关
Defects in SALL1 are the cause of Townes-Brocks syndrome (TBS) [MIM:107480]. TBS is a rare, autosomal dominant malformation syndrome with a combination of imperforate anus, triphalangeal and supernumerary thumbs, malformed ears and sensorineural hearing loss.
Defects in SALL1 may cause a phenotype overlapping with TBS, similar to bronchio-oto-renal syndrome (BOR) [MIM:113650]. BOR is an autosomal dominant disorder, manifested by various combinations of preauricular pits, branchial fistulae or cysts, lacrimal duct stenosis, hearing loss, structural defects of the outer, middle, or inner ear, and renal dysplasia. Associated defects include asthenic habitus, long narrow facies, constricted palate, deep overbite, and myopia. Hearing loss may be due to Mondini type cochlear defect and stapes fixation. -
序列相似性
Belongs to the sal C2H2-type zinc-finger protein family.
Contains 9 C2H2-type zinc fingers. -
发展阶段
In fetal brain exclusively in neurons of the subependymal region of hypothalamus lateral to the third ventricle. -
细胞定位
Nucleus. - Information by UniProt
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数据库链接
- Entrez Gene: 58198 Mouse
- SwissProt: Q9ER74 Mouse
- Unigene: 214361 Mouse
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别名
- HSal1 antibody
- Sal like protein 1 antibody
- Sal-1 antibody
see all
图片
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SALL1 antibody [K9814] (ab41974)Image courtesy of an anonymous Abreview
Ab41974 staining SALL1 in Mouse embryonic kidney at tissue sections by Immunohistochemistry (IHC- P- paraformaldehyde-fixed, paraffin- embedded sections). Tissue was fixed with paraformaldehyde and blocked with 10µg/ml BSA for 1 hour at 25oC; antigen retrieval was by heat mediation in a Tris/EDTA (pH9). Samples were incubated with primary antibody (1/100 with 6% Horse serum in PBST) for 16hours at 4oC. An Alexa Fluor® 568 donkey anti-mouse polyclonal (1/500 dilution) was used as the secondary antibody.
This image was generated using the ascites version of the product.
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![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SALL1 antibody [K9814] (ab41974)](https://www.abcam.cn/ps/products/41/ab41974/Images/ab41974-305310-anti-sall1-antibody-k9814-immunohistochemistry.jpg)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SALL1 antibody [K9814] (ab41974)ab41974 staining SALL1 in Mouse embryo kidnet tissue sections by Immunohistochemistry (IHC-P - paraformaldehyde-fixed, paraffin-embedded sections).
This image was generated using the ascites version of the product.
数据表及文件
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SDS download
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Datasheet download
文献 (5)
ab41974 被引用在 5 文献中.
- Qiu Z et al. The significance of glycolysis index and its correlations with immune infiltrates in Alzheimer's disease. Front Immunol 13:960906 (2022). PubMed: 36353631
- Pantier R et al. SALL4 controls cell fate in response to DNA base composition. Mol Cell 81:845-858.e8 (2021). PubMed: 33406384
- Qian C et al. Hsa_circ_0043265 Restrains Cell Proliferation, Migration and Invasion of Tongue Squamous Cell Carcinoma via Targeting the miR-1243/SALL1 Axis. Pathol Oncol Res 27:587130 (2021). PubMed: 34257535
- Hernandez JOR et al. A tissue-bioengineering strategy for modeling rare human kidney diseases in vivo. Nat Commun 12:6496 (2021). PubMed: 34764250
- Salman H et al. SALL1 expression in acute myeloid leukemia. Oncotarget 9:7442-7452 (2018). PubMed: 29484122