AB181190

重组Anti-Sacsin抗体[EPR11864]

Anti-Sacsin antibody [EPR11864]

RabMAb
Recombinant
了解详情

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(5 Publications)

Rabbit Recombinant Monoclonal Sacsin antibody. Suitable for WB and reacts with Human samples. Cited in 5 publications.

查看别名

DNAJC29, KIAA0730, SACS, Sacsin, DnaJ homolog subfamily C member 29

2 Images

Unknown

Western blot - Anti-Sacsin antibody [EPR11864] (AB181190)

All lanes:

Western blot - Anti-Sacsin antibody [EPR11864] (ab181190) at 1/2000 dilution

All lanes:

Human fetal brain at 20 µg

Secondary

All lanes:

Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Predicted band size: 521 kDa

Observed band size: 437 kDa

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Supplier Data

Western blot - Anti-Sacsin antibody [EPR11864] (AB181190)

All lanes:

Western blot - Anti-Sacsin antibody [EPR11864] (ab181190) at 1/5000 dilution

All lanes:

Human glioma tissue lysate at 20 µg

Secondary

All lanes:

Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Predicted band size: 521 kDa

Observed band size: 437 kDa

false

不同偶联物与剂型 (1)

Carrier free

Anti-Sacsin antibody [EPR11864] - BSA and Azide free

关键信息

宿主种属

Rabbit

克隆

Monoclonal

克隆号

EPR11864

亚型

IgG

不含载体蛋白

反应种属

Human

应用

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/2000", "WB-species-notes": "<p></p>" } } }

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产品详情

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Protein A

存储溶液

Preservative: 0.01% Sodium azide Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Co-chaperone which acts as a regulator of the Hsp70 chaperone machinery and may be involved in the processing of other ataxia-linked proteins.

See full target information SACS

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文献 (5)

Recent publications for all applications. Explore the full list and refine your search

JCI insight 8: PubMed37159335

2023

Restoring calcium homeostasis in Purkinje cells arrests neurodegeneration and neuroinflammation in the ARSACS mouse model.

Applications

Unspecified application

Species

Unspecified reactive species

Andrea Del Bondio,Fabiana Longo,Daniele De Ritis,Erica Spirito,Paola Podini,Bernard Brais,Angela Bachi,Angelo Quattrini,Francesca Maltecca

Cell reports 41:111580 PubMed36323248

2022

Multi-omic profiling reveals the ataxia protein sacsin is required for integrin trafficking and synaptic organization.

Applications

Unspecified application

Species

Unspecified reactive species

Lisa E L Romano,Wen Yih Aw,Kathryn M Hixson,Tatiana V Novoselova,Tammy M Havener,Stefanie Howell,Bonnie Taylor-Blake,Charlotte L Hall,Lei Xing,Josh Beri,Suran Nethisinghe,Laura Perna,Abubakar Hatimy,Ginevra Chioccioli Altadonna,Lee M Graves,Laura E Herring,Anthony J Hickey,Konstantinos Thalassinos,J Paul Chapple,Justin M Wolter

International journal of molecular sciences 22: PubMed34769152

2021

Hsp90 Inhibition: A Promising Therapeutic Approach for ARSACS.

Applications

Unspecified application

Species

Unspecified reactive species

Suran Nethisinghe,Rosella Abeti,Maheswaran Kesavan,W Christian Wigley,Paola Giunti

Neurology 97:e2315-e2327 PubMed34649874

2021

Assessment of Sacsin Turnover in Patients With ARSACS: Implications for Molecular Diagnosis and Pathogenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Fabiana Longo,Daniele De Ritis,Annarita Miluzio,Davide Fraticelli,Jonathan Baets,Marina Scarlato,Filippo M Santorelli,Stefano Biffo,Francesca Maltecca

Molecular brain 12:19 PubMed30866998

2019

Sacs R272C missense homozygous mice develop an ataxia phenotype.

Applications

Unspecified application

Species

Unspecified reactive species

Roxanne Larivière,Nicolas Sgarioto,Brenda Toscano Márquez,Rébecca Gaudet,Karine Choquet,R Anne McKinney,Alanna J Watt,Bernard Brais

View all publications

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Abcam Product Promise

我们致力于为您的研究提供高质量的试剂，为您科研的每一步提供支持。若我们的产品未能达到预期性能，我们向您提供 Abcam Product Promise 保障。

详情请参阅我们的条款与条件。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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重组Anti-Sacsin抗体[EPR11864]