Anti-S1P抗体- C-terminal (ab224618)
Key features and details
- Rabbit polyclonal to S1P - C-terminal
- Suitable for: WB, IHC-P
- Reacts with: Mouse, Human
- Isotype: IgG
概述
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产品名称
Anti-S1P抗体- C-terminal
参阅全部 S1P 一抗 -
描述
兔多克隆抗体to S1P - C-terminal -
宿主
Rabbit -
经测试应用
适用于: WB, IHC-Pmore details -
种属反应性
与反应: Mouse, Human
预测可用于: Rat, Chinese hamster
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免疫原
Recombinant fragment corresponding to Human S1P aa 800 to the C-terminus (C terminal).
Database link: Q14703 -
阳性对照
- IHC-P: Human lung and small intestine tissues.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), PBS -
Concentration information loading... -
纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Positive Controls
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab224618于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB | (1) |
Use at an assay dependent concentration.
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| IHC-P |
1/20 - 1/200.
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| 说明 |
|---|
|
WB
Use at an assay dependent concentration. |
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IHC-P
1/20 - 1/200. |
靶标
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相关性
S1P (also known as MBTPS1,SKI1), was first discovered as one of two enzymes that cleave the sterol regulatory binding proteins (SREBPs), in the case of S1P at “site-1,” a hydrophillic loop extending into the lumen of the ER. The MBTPS1 domain structure contains a signal sequence followed by a propeptide domain, a catalytic domain, a transmembrane domain and a cytoplasmic domain. -
细胞定位
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. -
数据库链接
- Entrez Gene: 100689417 Chinese hamster
- Entrez Gene: 8720 Human
- Entrez Gene: 56453 Mouse
- Entrez Gene: 89842 Rat
- Omim: 603355 Human
- SwissProt: Q9Z2A8 Chinese hamster
- SwissProt: Q14703 Human
- SwissProt: Q9WTZ2 Mouse
see all -
别名
- kexin isozyme 1 antibody
- KIAA0091 antibody
- MBTPS1 antibody
see all
图片
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-S1P antibody - C-terminal (ab224618)
Paraffin-embedded human small intestine tissue stained for S1P using ab224618 at 1/100 dilution in immunohistochemical analysis.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-S1P antibody - C-terminal (ab224618)Paraffin-embedded human lung tissue stained for S1P using ab224618 at 1/100 dilution in immunohistochemical analysis.
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
数据表及文件
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SDS download
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Datasheet download
文献 (2)
ab224618 被引用在 2 文献中.
- Chang YC et al. Feline mammary carcinoma-derived extracellular vesicle promotes liver metastasis via sphingosine kinase-1-mediated premetastatic niche formation. Lab Anim Res 39:27 (2023). PubMed: 37941082
- Wu X et al. Inhibition of SphK1/S1P Signaling Pathway Alleviates Fibrosis and Inflammation of Rat Myocardium after Myocardial Infarction. Comput Math Methods Med 2022:5985375 (2022). PubMed: 35872958