AB40833

Anti-RPS19抗体

Name: RPS19抗体 (ab40833)| Abcam中文官网
Brand: Abcam Limited
SKU: AB40833
Price: 4845 CNY
Availability: InStock
Rating: 2 (2 reviews)

Anti-RPS19 antibody

(2 Reviews)

(7 Publications)

Goat Polyclonal RPS19 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 7 publications. Immunogen corresponding to Synthetic Peptide within Human 40S ribosomal protein S19 aa 100 to C-terminus.

查看别名

Small ribosomal subunit protein eS19, 40S ribosomal protein S19, RPS19

1 Images

Unknown

Western blot - Anti-RPS19 antibody (AB40833)

All lanes:

Western blot - Anti-RPS19 antibody (ab40833) at 0.1 µg/mL

All lanes:

K562 cell lysate in RIPA buffer at 35 µg

Predicted band size: 16 kDa

Observed band size: 15 kDa

false

关键信息

宿主种属

Goat

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Human

应用

WB, IHC-P

applications

免疫原

Synthetic Peptide within Human 40S ribosomal protein S19 aa 100 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

P39019

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5 µg/mL", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.1-0.3 µg/mL", "WB-species-notes": "<p>1 hour primary incubation is recommended for this product.</p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Cat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Chimpanzee": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Cow": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Dog": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rhesus monkey": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

纯化说明

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.

存储溶液

pH: 7.3 Preservative: 0.02% Sodium azide Constituents: Tris buffered saline, 0.5% BSA

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

RPS19 also known as Ribosomal Protein S19 is a component of the small 40S ribosomal subunit. It has a molecular weight of approximately 16 kDa. This protein is widely expressed in many tissues including the bone marrow and spleen which are important for hematopoiesis. RPS19 plays a mechanical role in ensuring the formation and function of ribosomes which are essential for protein synthesis. By participating in ribosome assembly it supports the translational machinery of cells.

Biological function summary

Ribosomal protein S19 holds a critical place in ribosome biogenesis. It is part of the ribosomal protein family and works together with other ribosomal proteins to create functional ribosomes necessary for cellular protein synthesis. As part of the 40S ribosomal subunit RPS19 facilitates the accurate translation of mRNA into proteins which is fundamental for cell growth and proliferation. The 40S subunit alongside the 60S subunit completes the formation of the functional ribosome.

Pathways

Ribosomal protein S19 contributes to the essential process of translation an important pathway within cell biology. It plays a part in the ribosome assembly pathway a pivotal process necessary for cell survival and function. RPS19 interacts closely with other ribosomal proteins such as RPS24 and RPS14 ensuring the proper assembly and functionality of the ribosomal subunits. These interactions are integral to maintaining cellular homeostasis and protein production.

Ribosomal protein S19 is associated with Diamond-Blackfan Anemia a rare genetic anemia caused by ribosomal protein mutations. This condition arises due to defective ribosome biogenesis leading to impaired erythropoiesis. Mutations in RPS19 reduce the ribosome's capacity to synthesize proteins specifically affecting red blood cell production. Additionally the protein is related to other ribosomal anomalies that connect to various bone marrow failure syndromes.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Component of the small ribosomal subunit (PubMed : 23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed : 23636399). Required for pre-rRNA processing and maturation of 40S ribosomal subunits (PubMed : 16990592). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed : 34516797).

See full target information 40S ribosomal protein S19

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文献 (7)

Recent publications for all applications. Explore the full list and refine your search

Life science alliance 6: PubMed37105715

2023

Myc controls NK cell development, IL-15-driven expansion, and translational machinery.

Applications

Unspecified application

Species

Unspecified reactive species

Hanif J Khameneh,Nicolas Fonta,Alessandro Zenobi,Charlène Niogret,Pedro Ventura,Concetta Guerra,Ivo Kwee,Andrea Rinaldi,Matteo Pecoraro,Roger Geiger,Andrea Cavalli,Francesco Bertoni,Eric Vivier,Andreas Trumpp,Greta Guarda

Experimental hematology 111:66-78 PubMed35460833

2022

Downregulation of SATB1 by miRNAs reduces megakaryocyte/erythroid progenitor expansion in preclinical models of Diamond-Blackfan anemia.

Applications

Unspecified application

Species

Unspecified reactive species

Mark C Wilkes,Vanessa Scanlon,Aya Shibuya,Alma-Martina Cepika,Ascia Eskin,Zugen Chen,Anupama Narla,Bert Glader,Maria Grazia Roncarolo,Stanley F Nelson,Kathleen M Sakamoto

Nature communications 11:3344 PubMed32620751

2020

Diamond Blackfan anemia is mediated by hyperactive Nemo-like kinase.

Applications

Unspecified application

Species

Unspecified reactive species

M C Wilkes,K Siva,J Chen,G Varetti,M Y Youn,H Chae,F Ek,R Olsson,T Lundbäck,D P Dever,T Nishimura,A Narla,B Glader,H Nakauchi,M H Porteus,C E Repellin,H T Gazda,S Lin,M Serrano,J Flygare,K M Sakamoto

Blood 124:3791-8 PubMed25270909

2014

TNF-mediated inflammation represses GATA1 and activates p38 MAP kinase in RPS19-deficient hematopoietic progenitors.

Applications

Unspecified application

Species

Unspecified reactive species

Elena Bibikova,Min-Young Youn,Nadia Danilova,Yukako Ono-Uruga,Yoan Konto-Ghiorghi,Rachel Ochoa,Anupama Narla,Bertil Glader,Shuo Lin,Kathleen M Sakamoto

Journal of cellular physiology 229:1047-60 PubMed24347309

2013

Identification of the PKR nuclear interactome reveals roles in ribosome biogenesis, mRNA processing and cell division.

Applications

Unspecified application

Species

Unspecified reactive species

William L Blalock,Manuela Piazzi,Alberto Bavelloni,Mirco Raffini,Irene Faenza,Antonietta D'Angelo,Lucio Cocco

Blood 119:262-72 PubMed22058113

2011

Ribosomal deficiencies in Diamond-Blackfan anemia impair translation of transcripts essential for differentiation of murine and human erythroblasts.

Applications

Species

Mouse

Rastislav Horos,Hanna Ijspeert,Dagmar Pospisilova,Regine Sendtner,Charlotte Andrieu-Soler,Erdogan Taskesen,Andrzej Nieradka,Radek Cmejla,Michael Sendtner,Ivo P Touw,Marieke von Lindern

Immunity 32:329-41 PubMed20206555

2010

Delivery of cytosolic components by autophagic adaptor protein p62 endows autophagosomes with unique antimicrobial properties.

Applications

ICC/IF

Species

Mouse

Marisa Ponpuak,Alexander S Davis,Esteban A Roberts,Monica A Delgado,Christina Dinkins,Zijiang Zhao,Herbert W Virgin,George B Kyei,Terje Johansen,Isabelle Vergne,Vojo Deretic

View all publications

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Anti-RPS19抗体

Anti-RPS19 antibody

Western blot - Anti-RPS19 antibody (AB40833)