Anti-RNF135抗体(ab272590)
Key features and details
- Rabbit polyclonal to RNF135
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-RNF135抗体
参阅全部 RNF135 一抗 -
描述
兔多克隆抗体to RNF135 -
宿主
Rabbit -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Human -
免疫原
Recombinant fragment corresponding to Human RNF135 aa 150-300.
Database link: Q8IUD6 -
阳性对照
- WB: T-47D (Human ductal breast epithelial tumor cell line).
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.20
Preservative: 0.02% Sodium azide
Constituents: 40% Glycerol (glycerin, glycerine), PBS -
Concentration information loading... -
纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab272590于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB |
Use a concentration of 0.04 - 0.4 µg/ml.
|
| 说明 |
|---|
|
WB
Use a concentration of 0.04 - 0.4 µg/ml. |
靶标
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功能
Acts as an E2-dependent E3 ubiquitin-protein ligase, involved in innate immune defense against viruses. Ubiquitinates DDX58 and is required for full activation of the DDX58 signaling resulting in interferon beta production. -
组织特异性
Expressed in skeletal muscle, spleen, kidney, placenta, prostate, stomach, thyroid and tongue. Also weakly expressed in heart, thymus, liver and lung. -
通路
Protein modification; protein ubiquitination. -
疾病相关
Defects in RNF135 are the cause of macrocephaly macrosomia facial dysmorphism syndrome (MMFD) [MIM:614192]. MMFD is an autosomal dominant disorder characterized by the association of macrothrombocytopathy and progressive sensorineural hearing loss without renal dysfunction. -
序列相似性
Contains 1 B30.2/SPRY domain.
Contains 1 RING-type zinc finger. -
细胞定位
Cytoplasm. - Information by UniProt
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数据库链接
- Entrez Gene: 84282 Human
- Omim: 611358 Human
- SwissProt: Q8IUD6 Human
- Unigene: 29874 Human
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别名
- E3 ubiquitin-protein ligase RNF135 antibody
- L13 antibody
- MGC13061 antibody
see all
图片
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Western blot - Anti-RNF135 antibody (ab272590)Lane 2 : Anti-RNF135 antibody (ab272590) at 0.4 µg/ml
Lane 1 : Molecular weight ladder
Lane 2 : T-47D
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
数据表及文件
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SDS download
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Datasheet download
文献 (0)
ab272590 尚未被引用在任何文献中。