AB200713

Anti-RND2抗体

Name: RND2抗体 (ab200713)| Abcam中文官网
Brand: Abcam Limited
SKU: AB200713
Price: 4606 CNY
Availability: InStock

Anti-RND2 antibody

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(1 Publication)

Rabbit Polyclonal RND2 antibody. Suitable for WB and reacts with Human, Mouse, Rat samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human RND2 aa 150 to C-terminus.

查看别名

ARHN, RHO7, RND2, Rho-related GTP-binding protein RhoN, Rho family GTPase 2, Rho-related GTP-binding protein Rho7, Rnd2

1 Images

Supplier Data

Western blot - Anti-RND2 antibody (AB200713)

All lanes:

Western blot - Anti-RND2 antibody (ab200713) at 1/500 dilution

Lane 1:

HEK293T whole cell lysate

Lane 2:

sp2/0 whole cell lysate

Lane 3:

PC12 whole cell lysate

Predicted band size: 25 kDa

false

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Mouse, Rat, Human

应用

applications

免疫原

Synthetic Peptide within Human RND2 aa 150 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

P52198

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500", "WB-species-notes": "" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500", "WB-species-notes": "" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

纯化说明

ab200713 was affinity-purified from Rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).

存储溶液

pH: 7.2 Preservative: 0.1% Sodium azide Constituents: PBS

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

RND2 also known as Rhonadin-2 is a small GTP-binding protein with a molecular weight of approximately 24 kDa. It belongs to the Rho family of GTPases and functions mechanically as a regulator of the actin cytoskeleton. This protein controls cellular processes such as migration and cytoskeletal organization through its ability to cycle between an active GTP-bound state and an inactive GDP-bound state. RND2 is expressed in various tissues but shows significant presence in the neural tissues where it plays an important role in neuronal morphology.

Biological function summary

This protein plays a significant role in neuronal development and differentiation. It is not typically a part of other protein complexes but directly interacts with effector proteins involved in actin dynamics. RND2 modulates processes such as axonal guidance and dendritic spine formation contributing to nerve cell communication and network formation during brain development. Its ability to control actin polymerization helps in shaping the structural integrity of neurons which is essential for their proper functioning.

Pathways

RND2 influences cellular actions by integrating into the actin cytoskeleton signaling pathway and the neurotrophin signaling pathway. The actin cytoskeleton pathway involves changes in cell shape and movement through interactions with proteins like ROCK2 and cofilin which RND2 regulates. Neurotrophin pathways affect neuronal survival and growth where RND2 acts alongside proteins like NTRK2 impacting the development and maintenance of the neuronal system.

RND2 has implications in neurodevelopmental disorders and cancer. Mutations or dysregulation of this protein might contribute to conditions like intellectual disability due to its critical role in neuronal development. Moreover aberrant expression of RND2 links to cancer metastasis as its regulation of cell movement and invasion can drive tumor progression. In cancer RND2 interacts with proteins like Rac1 affecting pathways that control tumor cell migration and invasion.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

May be specifically involved in neuronal and hepatic functions. Is a C3 toxin-insensitive member of the Rho subfamily (By similarity).

See full target information RND2

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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Microbiology and immunology 66:433-441 PubMed35568971

2022

Diagnostic value of lncRNA NORAD in pulmonary tuberculosis and its regulatory role in Mycobacterium tuberculosis infection of macrophages.

Applications

Unspecified application

Species

Unspecified reactive species

Wenna Sun,Xiong He,Xiushuang Zhang,Xiaomeng Wang,Wen Lin,Xiaofeng Wang,Yan Liang

View all publications

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Anti-RND2抗体

Anti-RND2 antibody

Western blot - Anti-RND2 antibody (AB200713)