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AB97808

Anti-RIC8A 抗体

Anti-RIC8A antibody

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(3 Publications)

Rabbit Polyclonal RIC8A antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human RIC8A aa 500-550.

查看别名

Chaperone Ric-8A, Synembryn-A, RIC8A

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RIC8A antibody (AB97808)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RIC8A antibody (AB97808)

ab97808, at a 1/100 dilution, staining RIC8A in paraffin embedded Adrenal cortical tumor by Immunohistochemistry.

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

No

反应种属

Human

应用

IHC-P, WB

applications

免疫原

Synthetic Peptide within Human RIC8A aa 500-550. The exact immunogen used to generate this antibody is proprietary information.

Q9NPQ8

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替代产品

Primary Antibodies

AB194941

Anti-RIC8A antibody

Immunoprecipitation - Anti-RIC8A antibody (AB194941)

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搭配使用产品

Primary Antibodies

AB234822

Anti-GNA11 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GNA11 antibody (AB234822)

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Primary Antibodies

AB210004

Anti-GNAQ antibody [EPR20978]

RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GNAQ antibody [EPR20978] (AB210004)

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Primary Antibodies

AB215717

Anti-eNOS (phospho S1177) antibody [EPR20991]

RabMAb|Recombinant|20ul selling size

Immunoprecipitation - Anti-eNOS (phospho S1177) antibody [EPR20991] (AB215717)

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Primary Antibodies

AB155782

Anti-DZIP3 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DZIP3 antibody (AB155782)

  • 0
  • 0
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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" } } }
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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Immunogen
存储溶液
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
运输条件
Blue Ice
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

RIC8A also known as Synembryn-A is a guanine nucleotide exchange factor that plays an important mechanical role in cellular signaling. It catalyzes the exchange of GDP for GTP on G protein alpha subunits activating them. RIC8A weighs approximately 60 kDa and is mainly cytoplasmic. Researchers have identified its expression in several tissues such as the brain heart and lungs indicating a wide pattern of activity in the body.
Biological function summary

RIC8A is involved in intracellular signaling and regulation of G-protein coupled receptor (GPCR) pathways. It does not directly form part of a stable complex but interacts transiently with heterotrimeric G proteins during activation. Through these interactions RIC8A influences processes such as neurotransmitter release cell division and hormone secretion. It also affects synaptic signals and is important for proper brain function.

Pathways

RIC8A plays a significant role in the Wnt signaling and synaptic transmission pathways. It operates by interacting with GPCR-related proteins like G-alpha subunits which are coupled later to downstream effectors. In the Wnt signaling pathway RIC8A supports signal propagation critical for cell fate determination. The synaptic transmission pathway further benefits from RIC8A's role in modulating neurotransmitter release making it essential for neural communication.

Researchers have linked RIC8A dysfunction to various neurological disorders and cancer. Abnormal RIC8A function can contribute to conditions like epilepsy and certain types of tumor growth owing to its role in cell signaling and division. The interaction of RIC8A with proteins like G-alpha subunits and components of the Wnt signaling pathway highlights its involvement in these diseases. Such associations suggest potential therapeutic target opportunities for addressing these complex conditions.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

Chaperone that specifically binds and folds nascent G alpha proteins prior to G protein heterotrimer formation, promoting their stability and activity : folds GNAI1, GNAO1, GNA13 and GNAQ (By similarity). Does not fold G(s) G-alpha proteins GNAS nor GNAL (By similarity). Also acts as a guanine nucleotide exchange factor (GEF) for G alpha proteins by stimulating exchange of bound GDP for free GTP (By similarity). Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein (GNAI1), possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex (By similarity). Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation (PubMed : 16629901).
See full target information RIC8A
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文献 (3)

Recent publications for all applications. Explore the full list and refine your search

eLife 8: PubMed31741433

2019

Genome-wide CRISPR screening reveals genetic modifiers of mutant EGFR dependence in human NSCLC.

Applications

Unspecified application

Species

Unspecified reactive species

Hao Zeng,Johnny Castillo-Cabrera,Mika Manser,Bo Lu,Zinger Yang,Vaik Strande,Damien Begue,Raffaella Zamponi,Shumei Qiu,Frederic Sigoillot,Qiong Wang,Alicia Lindeman,John S Reece-Hoyes,Carsten Russ,Debora Bonenfant,Xiaomo Jiang,Youzhen Wang,Feng Cong

Genes to cells : devoted to molecular & cellular mechanisms 22:293-309 PubMed28185378

2017

Ric-8A, an activator protein of Gαi, controls mammalian epithelial cell polarity for tight junction assembly and cystogenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Kanako Chishiki,Sachiko Kamakura,Junya Hayase,Hideki Sumimoto

PloS one 9:e86680 PubMed24466196

2014

Resistance to inhibitors of cholinesterase (Ric)-8A and Gαi contribute to cytokinesis abscission by controlling vacuolar protein-sorting (Vps)34 activity.

Applications

IP, WB, ICC/IF

Species

Human, Human, Human

Cedric Boularan,Olena Kamenyeva,Hyeseon Cho,John H Kehrl
View all publications
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