重组Anti-RGS6抗体[EPR6342] (ab128943)
![Western blot - Anti-RGS6 antibody [EPR6342] (ab128943)](https://www.abcam.cn/ps/products/128/ab128943/Images/RGS6-Primary-antibodies-ab128943-1.jpg "Western blot - Anti-RGS6 antibody [EPR6342] (ab128943)")
Key features and details
- Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
- Rabbit monoclonal [EPR6342] to RGS6
- Suitable for: WB
- Reacts with: Mouse, Rat, Human
Related conjugates and formulations
概述
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产品名称
Anti-RGS6抗体[EPR6342]
参阅全部 RGS6 一抗 -
描述
兔单克隆抗体[EPR6342] to RGS6 -
宿主
Rabbit -
经测试应用
适用于: WBmore details
不适用于: Flow Cyt,ICC/IF,IHC-P or IP -
种属反应性
与反应: Mouse, Rat, Human -
免疫原
Synthetic peptide within Human RGS6 aa 400-500. The exact sequence is proprietary.
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阳性对照
- Y79, HeLa and Jurkat cell lysates
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常规说明
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free production
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
解离常数（KD）
KD = 3.50 x 10 -12 M Learn more about KD -
存储溶液
pH: 7.20
Preservative: 0.01% Sodium azide
Constituents: 9% PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, 50% Tissue culture supernatant -
Concentration information loading... -
纯度
Protein A purified -
克隆
单克隆 -
克隆编号
EPR6342 -
同种型
IgG -
研究领域
相关产品
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Alternative Versions
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Isotype control
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Positive Controls
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab128943于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB |
1/1000 - 1/10000. Predicted molecular weight: 54 kDa.
|
| 说明 |
|---|
|
WB
1/1000 - 1/10000. Predicted molecular weight: 54 kDa. |
应用说明
Is unsuitable for Flow Cyt,ICC/IF,IHC-P or IP.
靶标
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功能
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(o)-alpha is specifically enhanced by the RGS6/Gbeta5 dimer. -
序列相似性
Contains 1 DEP domain.
Contains 1 G protein gamma domain.
Contains 1 RGS domain. -
细胞定位
Cytoplasm. Membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 9628 Human
- Entrez Gene: 50779 Mouse
- Entrez Gene: 54295 Rat
- Omim: 603894 Human
- SwissProt: P49758 Human
- SwissProt: Q9Z2H2 Mouse
- SwissProt: P49801 Rat
- Unigene: 509872 Human
see all -
别名
- FLJ43552 antibody
- G protein signaling 6 regulator antibody
- GAP antibody
see all
图片
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Western blot - Anti-RGS6 antibody [EPR6342] (ab128943)All lanes : Anti-RGS6 antibody [EPR6342] (ab128943) at 1/1000 dilution
Lane 1 : Y79 (Human retinoblastoma cell line) cell lysate
Lane 2 : HeLa cell lysate
Lane 3 : Jurkat cell lysate
Lysates/proteins at 10 µg per lane.
Secondary
All lanes : HRP labelled goat anti-rabbit at 1/2000 dilution
Predicted band size: 54 kDa -
![OI-RD Scanning - Anti-RGS6 antibody [EPR6342] (ab128943)](https://www.abcam.cn/ps/products/128/ab128943/Images/RGS6-Primary-antibodies-ab128943-2.jpg)
OI-RD Scanning - Anti-RGS6 antibody [EPR6342] (ab128943) -
![Western blot - Anti-RGS6 antibody [EPR6342] (ab128943)](https://www.abcam.cn/ps/products/128/ab128943/Images/ab128943-281305-ab128943.jpg)
Western blot - Anti-RGS6 antibody [EPR6342] (ab128943)All lanes : Anti-RGS6 antibody [EPR6342] (ab128943) at 1/1000 dilution
Lane 1 : mouse brain
Lane 2 : rat brain
Predicted band size: 54 kDa
Exposure time: 3 minutes -
![Anti-RGS6 antibody [EPR6342] (ab128943)](https://www.abcam.cn/ps/products/128/ab128943/Images/ab128943-4-benefits-of-recombinant-antibodies.png)
Anti-RGS6 antibody [EPR6342] (ab128943)
数据表及文件
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SDS download
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Datasheet download
文献 (1)
ab128943 被引用在 1 文献中.
- Huang Z et al. Regulator of G Protein Signaling 6 Facilities Cardiac Hypertrophy by Activating Apoptosis Signal-Regulating Kinase 1-P38/c-JUN N-Terminal Kinase 1/2 Signaling. J Am Heart Assoc 7:e009179 (2018). PubMed: 30371330