AB110927

Anti-RFX1抗体

Name: RFX1抗体 (ab110927)| Abcam中文官网
Brand: Abcam Limited
SKU: AB110927
Price: 4744 CNY
Availability: InStock

Anti-RFX1 antibody

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(1 Publication)

Rabbit Polyclonal RFX1 antibody. Suitable for IP and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human RFX1 aa 200-250.

查看别名

MHC class II regulatory factor RFX1, Enhancer factor C, Regulatory factor X 1, Transcription factor RFX1, EF-C, RFX, RFX1

1 Images

Unknown

Immunoprecipitation - Anti-RFX1 antibody (AB110927)

Detection of RFX1 by Western Blot of Immunprecipitate.
anti-RFX1 at 0.4µg/ml staining RFX1 in HeLa whole cell lysate immunoprecipitated using ab110927 at 6µg/mg lysate (1 mg/IP; 20% of IP loaded/lane).
Detection : Chemiluminescence with exposure time of 10 seconds.

All lanes:

Immunoprecipitation - Anti-RFX1 antibody (ab110927)

Predicted band size: 104 kDa

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关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Human

应用

applications

免疫原

Synthetic Peptide within Human RFX1 aa 200-250. The exact immunogen used to generate this antibody is proprietary information.

P22670

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "testedAndGuaranteed", "IP-species-dilution-info": "2-5 µg/mg of lysate", "IP-species-notes": "<p></p>" }, "Chimpanzee": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "" }, "Gorilla": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "" }, "Rhesus monkey": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

纯化说明

ab110927 was affinity purified using an epitope specific to RFX1 immobilized on solid support.

存储溶液

pH: 7 - 8 Preservative: 0.09% Sodium azide Constituents: Tris citrate/phosphate

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Regulatory Factor X 1 (RFX1) also known as EF-C is a transcription factor essential for gene regulation. It has a mass of approximately 98 kDa. This protein is expressed in various tissues including the brain and immune cells influencing cellular functions in different contexts. It functions by binding to specific DNA sequences known as X-boxes located in the promoter regions of target genes. This binding regulates transcription impacting cell growth differentiation and immune response.

Biological function summary

RFX1 participates in a broader network of transcriptional regulation as part of the RFX protein family. It is involved in the regulation of genes necessary for cilia function and immune response. RFX1 often operates in synergy with other transcription factors forming complexes that modulate gene expression. It plays an important role in controlling the expression of genes critical for cell cycle regulation and apoptosis.

Pathways

The transcription factor RFX1 contributes to major biological pathways such as the MHC class II antigen presentation pathway and the cilia development pathway. It interacts with proteins like CIITA influencing immune response through the activation of MHC class II genes. By regulating these pathways RFX1 affects immune surveillance and cellular communication which are pivotal for maintaining cellular integrity and function.

Dysfunction or dysregulation of RFX1 relates to conditions such as cancer and autoimmune diseases. The protein's critical role in gene expression and the immune system highlights its contribution to oncogenic processes and disorders like systemic lupus erythematosus. It may interact with proteins such as STAT3 suggesting pathways through which RFX1 may influence inflammatory responses and tumorigenesis making it a potential target for therapeutic intervention.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Regulatory factor essential for MHC class II genes expression. Binds to the X boxes of MHC class II genes. Also binds to an inverted repeat (ENH1) required for hepatitis B virus genes expression and to the most upstream element (alpha) of the RPL30 promoter.

See full target information RFX1

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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in cell and developmental biology 9:698292 PubMed34458260

2021

3D Organoid Culture From Adult Salivary Gland Tissues as an Modeling of Salivary Gland Morphogenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Donghyun Kim,Yeo-Jun Yoon,Dojin Choi,Jisun Kim,Jae-Yol Lim

View all publications

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Anti-RFX1抗体

Anti-RFX1 antibody

Immunoprecipitation - Anti-RFX1 antibody (AB110927)