JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB228496

Anti-RFRP抗体

Anti-RFRP antibody

Be the first to review this product! Submit a review

|

(2 Publications)

Guinea pig Polyclonal RFRP antibody. Suitable for IHC-Fr and reacts with Sheep samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human NPVF aa 100-150 conjugated to Keyhole Limpet Haemocyanin.

查看别名

C7orf9, RFRP, NPVF, Pro-FMRFamide-related neuropeptide VF

4 Images
Immunohistochemistry (Frozen sections) - Anti-RFRP antibody (AB228496)
  • IHC-Fr

Supplier Data

Immunohistochemistry (Frozen sections) - Anti-RFRP antibody (AB228496)

4% PFA-fixed frozen sheep hypothalamus tissue stained for RFRP (green) using ab228496 at 1/2000 dilution in immunohistochemical analysis. Staining is not affected by preadsorption with Prolactin-releasing peptide (PrRP).

Immunohistochemistry (Frozen sections) - Anti-RFRP antibody (AB228496)
  • IHC-Fr

Supplier Data

Immunohistochemistry (Frozen sections) - Anti-RFRP antibody (AB228496)

4% PFA-fixed frozen sheep hypothalamus tissue stained for RFRP (green) using ab228496 at 1/2000 dilution in immunohistochemical analysis. Staining is not affected by preadsorption with Kisspeptin.

Immunohistochemistry (Frozen sections) - Anti-RFRP antibody (AB228496)
  • IHC-Fr

Supplier Data

Immunohistochemistry (Frozen sections) - Anti-RFRP antibody (AB228496)

4% PFA-fixed frozen sheep hypothalamus tissue stained for RFRP (green) using ab228496 at 1/2000 dilution in immunohistochemical analysis. Staining is not affected by preadsorption with NFF peptide.

Immunohistochemistry (Frozen sections) - Anti-RFRP antibody (AB228496)
  • IHC-Fr

Supplier Data

Immunohistochemistry (Frozen sections) - Anti-RFRP antibody (AB228496)

4% PFA-fixed frozen sheep hypothalamus tissue stained for RFRP (green) using ab228496 at 1/2000 dilution in immunohistochemical analysis.

关键信息

宿主种属

Guinea pig

克隆

Polyclonal

亚型

IgG

不含载体蛋白

No

反应种属

Sheep

应用

IHC-Fr

applications

免疫原

Synthetic Peptide within Human NPVF aa 100-150 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

Q9HCQ7

style
left-column

反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCFr" : {"fullname" : "Immunohistochemistry (Frozen sections)", "shortname":"IHC-Fr"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCFr-species-checked": "predicted", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "" }, "Sheep": { "IHCFr-species-checked": "testedAndGuaranteed", "IHCFr-species-dilution-info": "1/2000", "IHCFr-species-notes": "<p></p>" } } }
style
left-column
style
left-column

性能和储存信息

形式
Lyophilized
复溶
reconstitute with water at 50µL
纯度
Whole antiserum
存储溶液
pH: 7 - 7.4
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
style
left-column

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

RFRP also known as RFamide-related peptide ranges in mass from 1.38 kDa to 2.85 kDa depending on the specific peptide variant. RFRP is expressed in the central nervous system particularly in the hypothalamus and pituitary gland and also found within the testis and ovary tissues. It originates from the VGF peptide precursor and plays a role in modulating various physiological processes.
Biological function summary

The RFamide-related peptide influences reproductive functions such as the regulation of gonadotropin release. It functions as an inhibitory factor on the secretion of gonadotropin-releasing hormone (GnRH) working in tandem with other neuropeptides and factors. RFRP is not a part of a larger complex but interacts closely with related neurohormones to exert its physiological effects.

Pathways

Several neuroendocrine control systems involve the RFamide-related peptide. RFRP plays an important role in the hypothalamic-pituitary-gonadal (HPG) axis where it modulates the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). It interacts with receptor proteins like GPR147 which influences these essential pathways and subsequently affects reproductive system functionality.

The RFamide-related peptide has links to reproductive health issues such as delayed puberty and infertility. Abnormal activities or levels of RFRP can interfere with hormonal balance making it a potential target for addressing these reproductive system disorders. Additionally its regulation of GnRH suggests possible connections to disorders involving altered hormonal cycles including polycystic ovary syndrome (PCOS) where excessive or insufficient RFRP activity can disrupt cyclical hormone release patterns.
style
left-column
style
left-column

产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

靶点信息

Neuropeptide RFRP-1. Efficiently inhibits forskolin-induced production of cAMP. Acts as a potent negative regulator of gonadotropin synthesis and secretion (PubMed : 11025660, PubMed : 20027225). Induces secretion of prolactin (By similarity).. Neuropeptide NPVF. Efficiently inhibits forskolin-induced production of cAMP. Blocks morphine-induced analgesia.. Neuropeptide RFRP-2. Shows no inhibitory activity of forskolin-induced production of cAMP.
See full target information NPVF
style
left-column

文献 (2)

Recent publications for all applications. Explore the full list and refine your search

The Journal of neuroscience : the official journal of the Society for Neuroscience 44: PubMed39122556

2024

Single-Cell Profiling Uncovers Evolutionary Divergence of Hypocretin/Orexin Neuronal Subpopulations.

Applications

Unspecified application

Species

Unspecified reactive species

Dana Sagi,Muhammad Tibi,Inbal Admati,Tali Lerer-Goldshtein,Hannah Hochgerner,Amit Zeisel,Lior Appelbaum

Nutrients 13: PubMed34684588

2021

A Role for Peripheral Anandamide and 2-Arachidonoylglycerol in Short-Term Food Intake and Orexigenic Hypothalamic Responses in a Species with Continuous Nutrient Delivery.

Applications

Unspecified application

Species

Unspecified reactive species

Isabel van Ackern,Angela Kuhla,Björn Kuhla
View all publications
style
left-column
style
left-column
style
right-column

替代产品

Primary Antibodies

AB122738

Anti-RFRP antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RFRP antibody (AB122738)

  • 0
  • 0

搭配使用产品

Primary Antibodies

AB10352

Anti-NPFF antibody

Immunohistochemistry (Frozen sections) - Anti-NPFF antibody (AB10352)

  • 4
  • 1
Primary Antibodies

AB192890

Anti-LC3B antibody [EPR18709] - Autophagosome Marker

BOND RX™ Validated|RabMAb|Recombinant|KO Validated|Lab Essentials|20ul selling size

Western blot - Anti-LC3B antibody [EPR18709] - Autophagosome Marker (AB192890)

  • 5
  • 19
Primary Antibodies

AB268020

Anti-Fibronectin antibody [EPR23110-46]

KO Validated|RabMAb|Recombinant|Lab Essentials|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Fibronectin antibody [EPR23110-46] (AB268020)

  • 4
  • 5
Multiplex Kits

AB228525

Autophagy Marker (APG5L/ATG5, ATG16L1, ATG4B, ATG9A, Beclin 1, LC3B) Antibody Sampler Panel

Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Autophagy Marker (APG5L/ATG5, ATG16L1, ATG4B, ATG9A, Beclin 1, LC3B) Antibody Sampler Panel (AB228525)

  • 5
  • 1

Abcam Product Promise

我们致力于为您的研究提供高质量的试剂，为您科研的每一步提供支持。若我们的产品未能达到预期性能，我们向您提供 Abcam Product Promise 保障。
详情请参阅我们的条款与条件。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com