JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB22501

Anti-Respiratory Syncytial Virus Nucleoprotein抗体[B023]

Anti-Respiratory Syncytial Virus Nucleoprotein antibody [B023]

Be the first to review this product! Submit a review

|

(4 Publications)

Mouse Monoclonal NCAP antibody. Suitable for ELISA, sELISA, IHC-Fr and reacts with Respiratory syncytial virus samples. Cited in 4 publications.

查看别名

Nucleoprotein, Protein N, Nucleocapsid protein, N

关键信息

宿主种属

Mouse

克隆

Monoclonal

克隆号

B023

亚型

IgG1

不含载体蛋白

No

反应种属

Respiratory syncytial virus

应用

ELISA, sELISA, IHC-Fr

applications

特异性

This antibody recognises the 42kD RSV nucleo protein.

style
left-column

反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "sELISA" : {"fullname" : "Sandwich ELISA", "shortname":"sELISA"}, "IHCFr" : {"fullname" : "Immunohistochemistry (Frozen sections)", "shortname":"IHC-Fr"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Respiratory syncytial virus": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>", "sELISA-species-checked": "guaranteed", "sELISA-species-dilution-info": "", "sELISA-species-notes": "<p>Use ab22501 as detection antibody</p>", "IHCFr-species-checked": "guaranteed", "IHCFr-species-dilution-info": "1/100", "IHCFr-species-notes": "<p></p>" } } }
style
left-column

您可能对以下产品感兴趣:

AB274340

COVID-19 S-Protein (S1RBD) Human IgG ELISA Kit

0

0 Reviews

查看产品
为什么推荐这个？

我们推荐这个产品，因为它经常被用于相同的实验或相关的研究。

我们建议您务必查阅产品说明书，以确认其是否符合您的实验需求；若有疑问，也可联系我们的技术团队获取协助。

style
left-column
style
left-column

性能和储存信息

形式
Liquid
纯化说明
Protein A chromatography
存储溶液
Preservative: 0.09% Sodium azide Constituents: PBS
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
style
left-column

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Respiratory Syncytial Virus Nucleoprotein (RSV N protein) plays a central mechanical role in the replication and transcription of the RSV genome. It binds single-stranded RNA acting as a scaffold for the virus's RNA synthesis. The nucleocapsid protein another name for RSV N protein has a molecular mass of approximately 45 kilodaltons. It is expressed in cells infected by the RSV notably within the cytoplasm forming a protective helix around the viral RNA genome.
Biological function summary

Within the context of viral infection and replication RSV N protein is essential for packaging and protecting the viral RNA genome. It forms part of a complex with the phosphoprotein (P protein) and the large polymerase protein (L protein) to facilitate RNA replication and transcription. This complex ensures the stability and integrity of the viral genome allowing the virus to efficiently replicate and produce infectious particles. Therefore the nucleoprotein strongly influences the life cycle of the virus.

Pathways

The RSV N protein functional capacity is pivotal within the viral RNA transcription and replication pathways. It closely interacts with the phosphoprotein P enhancing the activity of the viral RNA-dependent RNA polymerase complex. This interaction synergistically ties into the virus's replication pathway ensuring the production of viral RNAs. The N protein also coordinates with M2-1 protein in regulating mRNA synthesis and RNA processing reflecting its comprehensive involvement in essential viral pathways.

The involvement of RSV N protein connects strongly to respiratory tract infections particularly in infants and the elderly. RSV infection often leads to bronchiolitis and pneumonia where the N protein plays an important role in propagating the disease. Its interaction with the fusion glycoprotein (F protein) facilitates virus assembly and release which enhances viral spread and subsequent infection severity. Researchers often focus on these proteins when developing therapeutics targeting RSV-related diseases.
style
left-column
style
left-column

产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

靶点信息

Encapsidates the viral RNA genome by forming a left-handed helical nucleocapsid that protects the RNA from nucleases (PubMed : 19965480, PubMed : 23677789, PubMed : 31229488). RNA replication depends on the availability of soluble nucleoprotein (PubMed : 22623798, PubMed : 9299631). The encapsidated genomic RNA is termed the NC and serves as template for transcription and replication (PubMed : 22623798). Together with the phosphoprotein, sequesters host NF-kappa-B in inclusion bodies (IBs) thereby inhibiting this host defense pathway (PubMed : 32878896). May also act as a modulator of the innate immune response by sequestration of host IFIH1/MDA5 and MAVS into IBs (PubMed : 22623778).
See full target information N
style
left-column

文献 (4)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 9:3999 PubMed30275522

2018

Engineered mRNA-expressed antibodies prevent respiratory syncytial virus infection.

Applications

Unspecified application

Species

Unspecified reactive species

Pooja Munnilal Tiwari,Daryll Vanover,Kevin E Lindsay,Swapnil Subhash Bawage,Jonathan L Kirschman,Sushma Bhosle,Aaron W Lifland,Chiara Zurla,Philip J Santangelo

Nature communications 8:667 PubMed28939853

2017

RSV glycoprotein and genomic RNA dynamics reveal filament assembly prior to the plasma membrane.

Applications

Unspecified application

Species

Unspecified reactive species

Daryll Vanover,Daisy V Smith,Emmeline L Blanchard,Eric Alonas,Jonathan L Kirschman,Aaron W Lifland,Chiara Zurla,Philip J Santangelo

Light, science & applications 5: PubMed27398242

2016

Mirror-enhanced super-resolution microscopy.

Applications

Unspecified application

Species

Unspecified reactive species

Xusan Yang,Hao Xie,Eric Alonas,Yujia Liu,Xuanze Chen,Philip J Santangelo,Qiushi Ren,Peng Xi,Dayong Jin

Journal of medical primatology 41:403-6 PubMed22931057

2012

Respiratory syncytial virus (RSV) pneumonia in a southern muriqui (Brachyteles arachnoides).

Applications

Unspecified application

Species

Unspecified reactive species

S V Santos,R F Strefezzi,A Pissinatti,C F H Takakura,C Kanamura,M I S Duarte,J L Catão-Dias
View all publications
style
left-column
style
left-column

Abcam Product Promise

我们致力于为您的研究提供高质量的试剂，为您科研的每一步提供支持。若我们的产品未能达到预期性能，我们向您提供 Abcam Product Promise 保障。
详情请参阅我们的条款与条件。
style
left-column
style
right-column

关联产品

Select an associated product type
Alternative Product
Primary Antibodies

AB94806

Anti-Respiratory Syncytial Virus Nucleoprotein antibody [RSV1C3]

primary-antibodies

respiratory-syncytial-virus-nucleoprotein-antibody-rsv1c3-ab94806

0

(0 reviews)

style
bg-slate-100

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com