AB204341

Anti-REEP6抗体

Name: REEP6抗体 (ab204341)| Abcam中文官网
Brand: Abcam Limited
SKU: AB204341
Price: 4606 CNY
Availability: InStock

Anti-REEP6 antibody

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(1 Publication)

Rabbit Polyclonal REEP6 antibody. Suitable for IHC-P, ICC, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human REEP6 aa 1-50.

查看别名

C19orf32, DP1L1, REEP6, Receptor expression-enhancing protein 6, Polyposis locus protein 1-like 1

6 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-REEP6 antibody (AB204341)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-REEP6 antibody (AB204341)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human liver tissue labelling REEP6 with ab204341 at 1/500 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

Supplier Data

Immunocytochemistry - Anti-REEP6 antibody (AB204341)

Immunocytochemistry analysis of HepG2 (human liver hepatocellular carcinoma cell line) cells labelling REEP6 with ab204341 at 2 μg/mL.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-REEP6 antibody (AB204341)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human skeletal muscle tissue labelling REEP6 with ab204341 at 1/500 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-REEP6 antibody (AB204341)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human small intestine tissue labelling REEP6 with ab204341 at 1/500 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-REEP6 antibody (AB204341)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human testis tissue labelling REEP6 with ab204341 at 1/500 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

Supplier Data

Western blot - Anti-REEP6 antibody (AB204341)

All lanes:

Western blot - Anti-REEP6 antibody (ab204341) at 1/500 dilution

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RT-4 cell lysate

Lane 2:

U-251 MG cell lysate

Lane 3:

Human plasma

Lane 4:

Human liver tissue lysate

Predicted band size: 20 kDa

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关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Human

应用

WB, ICC, IHC-P

applications

免疫原

Recombinant Fragment Protein within Human REEP6 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.

Q96HR9

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICC" : {"fullname" : "Immunocytochemistry", "shortname":"ICC"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/500 - 1/1000", "IHCP-species-notes": " Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICC-species-checked": "testedAndGuaranteed", "ICC-species-dilution-info": "0.25-2 µg/mL", "ICC-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

存储溶液

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

REEP6 also known as Receptor Expression Enhancing Protein 6 is a protein with a molecular mass of approximately 27 kDa. Its main mechanical role is to assist with the proper folding and expression of receptor proteins in the endoplasmic reticulum (ER). REEP6 is strongly expressed in retinal cells but it may also be present in lower levels in other tissues. By interacting with newly synthesized proteins REEP6 helps in their stabilization and transport to the cell surface.

Biological function summary

The REEP6 protein supports sensory neuron function by regulating receptor proteins critical for processing sensory inputs. It does this as part of protein complexes within ER membranes where it influences the trafficking of G protein-coupled receptors (GPCRs) specifically involved in visual photoreception. In the context of the retina REEP6 actions enable photoreceptors to respond correctly to light which is important for vision.

Pathways

Research identifies REEP6 as integral to cellular mechanisms related to protein processing and trafficking pathways. It plays a role along with proteins such as GPrin1 and Sec24C in the phototransduction pathway which converts light stimuli into visual signals. These pathways control how proteins are sorted and delivered to their destinations affecting overall cell communication and homeostasis.

Mutations in REEP6 are linked to retinitis pigmentosa a degenerative eye condition leading to vision loss. This disorder affects photoreceptor function and is connected to rhodopsin protein deficiencies which are common in patients with this type of retinal disorder. Variants in REEP6 can also affect its function resulting in altered receptor expression that contributes to disease progression.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Required for correct function and survival of retinal photoreceptors (PubMed : 27889058). Required for retinal development (By similarity). In rod photoreceptors, facilitates stability and/or trafficking of guanylate cyclases and is required to maintain endoplasmic reticulum and mitochondrial homeostasis (By similarity). May play a role in clathrin-coated intracellular vesicle trafficking of proteins from the endoplasmic reticulum to the retinal rod plasma membrane (By similarity).

See full target information REEP6

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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Burns & trauma 12:tkad058 PubMed38250706

2024

Exosomal miR-4645-5p from hypoxic bone marrow mesenchymal stem cells facilitates diabetic wound healing by restoring keratinocyte autophagy.

Applications

Unspecified application

Species

Unspecified reactive species

Yan Shi,Shang Wang,Dewu Liu,Zhengguang Wang,Yihan Zhu,Jun Li,Kui Xu,Furong Li,Huicai Wen,Ronghua Yang

View all publications

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Anti-REEP6抗体

Anti-REEP6 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-REEP6 antibody (AB204341)

Immunocytochemistry - Anti-REEP6 antibody (AB204341)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-REEP6 antibody (AB204341)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-REEP6 antibody (AB204341)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-REEP6 antibody (AB204341)

Western blot - Anti-REEP6 antibody (AB204341)