AB221810

Anti-REEP5抗体

Name: REEP5抗体 (ab221810)| Abcam中文官网
Brand: Abcam Limited
SKU: AB221810
Price: 5757 CNY
Availability: InStock

Anti-REEP5 antibody

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(1 Publication)

Rabbit Polyclonal REEP5 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human REEP5 aa 100 to C-terminus.

查看别名

C5orf18, DP1, TB2, REEP5, Receptor expression-enhancing protein 5, Polyposis locus protein 1, Protein TB2

1 Images

Immunocytochemistry/ Immunofluorescence - Anti-REEP5 antibody (AB221810)

ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-REEP5 antibody (AB221810)

PFA-fixed, Triton X-100 permeabilized MCF7 (human breast adenocarcinoma cell line) cells stained for REEP5 (green) using ab221810 at 4 μg/ml in ICC/IF.

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Human

应用

ICC/IF

applications

免疫原

Recombinant Fragment Protein within Human REEP5 aa 100 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q00765

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" }, "Orangutan": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

存储溶液

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

REEP5 also known as Receptor Expression Enhancing Protein 5 facilitates cell machinery in organizing and shaping the membranes of the endoplasmic reticulum. This protein has a molecular mass of approximately 22 kDa. REEP5 is expressed abundantly in the heart and skeletal muscle though it also exists in other tissues at lower levels. The protein is known to assist in membrane topology which is essential for maintaining proper endoplasmic reticulum morphology and function.

Biological function summary

REEP5 supports endoplasmic reticulum tubule formation helping maintain the high curvature structure of the organelle. It becomes part of a larger protein complex contributing to the development and maintenance of the fine network structure typical of the endoplasmic reticulum. By doing so REEP5 plays a role in the spatial organization of the cellular environment ensuring the proper segregation and function of cellular components.

Pathways

REEP5 actively participates in cellular stress response and the unfolded protein response pathway. This pathway involves proteins such as IRE1 and PERK which sensor and manage cellular stress by regulating protein folding and assisting in maintaining homeostasis. REEP5 provides structural regulation in these pathways impacting protein synthesis and secretion processes which are essential for adapting to cellular demands and stress.

REEP5 has been implicated in heart conditions particularly dilated cardiomyopathy. This disorder involves the heart muscle becoming weakened and enlarged affecting its ability to pump blood efficiently. Mutations or dysregulation of REEP5 impact its interaction with proteins like ATL1 and ATL2 which are involved in membrane fusion processes. Additionally REEP5 has shown associations with neurodegenerative conditions indicating its wider significance in maintaining cellular health and function.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Plays an essential role in heart function and development by regulating the organization and function of the sarcoplasmic reticulum in cardiomyocytes.

See full target information REEP5

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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Proceedings of the National Academy of Sciences of the United States of America 121:e2404243121 PubMed39331410

2024

Subcellular activation of β-adrenergic receptors using a spatially restricted antagonist.

Applications

Unspecified application

Species

Unspecified reactive species

Federica Liccardo,Johannes Morstein,Ting-Yu Lin,Julius Pampel,Di Lang,Kevan M Shokat,Roshanak Irannejad

View all publications

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Anti-REEP5抗体

Anti-REEP5 antibody

Immunocytochemistry/ Immunofluorescence - Anti-REEP5 antibody (AB221810)