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AB106463

Anti-REEP3抗体

Anti-REEP3 antibody

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(4 Publications)

Rabbit Polyclonal REEP3 antibody. Suitable for WB and reacts with Rat samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human REEP3.

查看别名

C10orf74, REEP3, Receptor expression-enhancing protein 3

1 Images
Western blot - Anti-REEP3 antibody (AB106463)
  • WB

Unknown

Western blot - Anti-REEP3 antibody (AB106463)

All lanes:

Western blot - Anti-REEP3 antibody (ab106463) at 1 µg/mL

Lane 1:

Rat heart tissue lysate at 15 µg

Lane 2:

Rat heart tissue lysate at 15 µg with immunizing peptide

Predicted band size: 29 kDa

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关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

No

反应种属

Rat

应用

WB

applications

免疫原

Synthetic Peptide within Human REEP3. The exact immunogen used to generate this antibody is proprietary information.

Q6NUK4

特异性

At least three isoforms of REEP3 are known to exist; ab106463 will detect all three.

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-2 µg/mL", "WB-species-notes": "<p></p>" } } }
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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Immunogen
纯化说明
ab106463 was purified by affinity chromatography via a peptide column.
存储溶液
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
储存信息
Avoid freeze / thaw cycle
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

REEP3 also known as Receptor Accessory Protein 3 plays an important role in mechanical processes within the cell. This protein assists in shaping the endoplasmic reticulum (ER) by facilitating the stacking and proper organization of the ER membranes. REEP3 has a molecular weight of approximately 28 kDa. Its expression is widespread but shows significant presence in neuronal tissues suggesting a specialized role in these cells.
Biological function summary

REEP3 manages the structural integrity of the endoplasmic reticulum by interacting with other proteins involved in ER morphology. It forms part of a complex that includes microtubule-associated proteins which link the ER to the cytoskeleton enabling proper cellular function. Through this interaction REEP3 supports the maintenance of cellular homeostasis and can influence processes such as protein synthesis and transport.

Pathways

Proteins like REEP3 contribute to ER shaping pathways and cellular stress response mechanisms. It acts alongside proteins like ATLASTIN and SEIPIN in the ER network assembly. Specifically it connects with pathways managing ER stress responses which are vital in adapting to and regulating changes in protein folding demand.

Aberrations in REEP3 function associate with conditions affecting the nervous system such as hereditary spastic paraplegia (HSP). Mutations in REEP3 can lead to defects in ER morphology contributing to neurodegenerative processes. The protein interacts with SPG4 and REEP1 linking it to cytoskeletal abnormalities observed in these disorders. Understanding REEP3's precise role in these pathologies offers potential avenues for therapeutic intervention.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

Microtubule-binding protein required to ensure proper cell division and nuclear envelope reassembly by sequestering the endoplasmic reticulum away from chromosomes during mitosis. Probably acts by clearing the endoplasmic reticulum membrane from metaphase chromosomes.
See full target information REEP3
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文献 (4)

Recent publications for all applications. Explore the full list and refine your search

Human molecular genetics 31:2779-2795 PubMed35348668

2022

Transverse endoplasmic reticulum expansion in hereditary spastic paraplegia corticospinal axons.

Applications

Unspecified application

Species

Unspecified reactive species

Peng-Peng Zhu,Hui-Fang Hung,Natalia Batchenkova,Jonathon Nixon-Abell,James Henderson,Pengli Zheng,Benoit Renvoisé,Song Pang,C Shan Xu,Stephan Saalfeld,Jan Funke,Yuxiang Xie,Fabian Svara,Harald F Hess,Craig Blackstone

Nature 601:132-138 PubMed34912111

2021

ER proteins decipher the tubulin code to regulate organelle distribution.

Applications

Unspecified application

Species

Unspecified reactive species

Pengli Zheng,Christopher J Obara,Ewa Szczesna,Jonathon Nixon-Abell,Kishore K Mahalingan,Antonina Roll-Mecak,Jennifer Lippincott-Schwartz,Craig Blackstone

Molecular biology of the cell 30:1377-1389 PubMed30995177

2019

REEP3 and REEP4 determine the tubular morphology of the endoplasmic reticulum during mitosis.

Applications

Unspecified application

Species

Unspecified reactive species

Darshan Kumar,Banafsheh Golchoubian,Ilya Belevich,Eija Jokitalo,Anne-Lore Schlaitz

ACS chemical neuroscience 10:2033-2044 PubMed30284806

2018

Chronic Social Isolation Stress during Peri-Adolescence Alters Presynaptic Dopamine Terminal Dynamics via Augmentation in Accumbal Dopamine Availability.

Applications

Unspecified application

Species

Unspecified reactive species

Anushree N Karkhanis,Amy C Leach,Jordan T Yorgason,Ayse Uneri,Samuel Barth,Farr Niere,Nancy J Alexander,Jeffrey L Weiner,Brian A McCool,Kimberly F Raab-Graham,Mark J Ferris,Sara R Jones
View all publications
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