AB230026

Anti-REEP1抗体

Name: REEP1抗体 (ab230026)| Abcam中文官网
Brand: Abcam Limited
SKU: AB230026
Price: 4748 CNY
Availability: InStock

Anti-REEP1 antibody

Be the first to review this product! Submit a review

(2 Publications)

Rabbit Polyclonal REEP1 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human REEP1 aa 100 to C-terminus.

查看别名

C2orf23, SPG31, REEP1, Receptor expression-enhancing protein 1, Spastic paraplegia 31 protein

3 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-REEP1 antibody (AB230026)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-REEP1 antibody (AB230026)

Paraffin-embedded human brain tissue stained for REEP1 with ab230026 at 1/100 dilution in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-REEP1 antibody (AB230026)

Paraffin-embedded human testis tissue stained for REEP1 with ab230026 at 1/100 dilution in immunohistochemical analysis.

Supplier Data

Western blot - Anti-REEP1 antibody (AB230026)

All lanes:

Western blot - Anti-REEP1 antibody (ab230026) at 1/1000 dilution

All lanes:

Mouse gonadal tissue lysate

Secondary

All lanes:

Goat polyclonal to rabbit IgG at 1/10000 dilution

Predicted band size: 22 kDa

Observed band size: 22 kDa,80 kDa

true

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Mouse, Human

应用

IHC-P, WB

applications

免疫原

Recombinant Fragment Protein within Human REEP1 aa 100 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q9H902

style

left-column

反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

style

left-column

style

left-column

性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

存储溶液

pH: 7.3 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

style

left-column

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

REEP1 also known as Receptor Expression Enhancing Protein 1 is a protein with a mass of approximately 22.4 kDa. It plays a mechanical role in the modulation and shaping of the endoplasmic reticulum (ER) membrane. REEP1 is expressed in multiple tissues particularly in the nervous system where it contributes to the maintenance of ER morphology.

Biological function summary

The protein facilitates the trafficking of receptors and other proteins to the cell surface. REEP1 interacts as part of a complex with other ER-shaping proteins like atlastin and reticulon. It ensures efficient transport and proper function of specific proteins maintaining cellular homeostasis by assisting in the organization of the ER network.

Pathways

The protein plays a role in the ER-associated degradation (ERAD) pathway and the unfolded protein response (UPR). It has interactions with proteins such as atlastin-1 and spastin which are involved in ER dynamics and intracellular transport processes. These interactions are critical for cellular adaptation to stress and the refolding or disposal of misfolded proteins.

Mutations in REEP1 have been linked to hereditary spastic paraplegia (HSP) highlighting its role in neuronal function. The disorder involves progressive lower limb spasticity due to degeneration of the corticospinal tracts. REEP1 interacts with atlastin-1 a protein also linked to HSP forming a network important for maintaining neuronal integrity. Dysfunctional pathways involving REEP1 contribute to the pathology of these neurodegenerative conditions.

style

left-column

style

left-column

产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

style

left-column

靶点信息

Required for endoplasmic reticulum (ER) network formation, shaping and remodeling; it links ER tubules to the cytoskeleton. May also enhance the cell surface expression of odorant receptors (PubMed : 20200447). May play a role in long-term axonal maintenance (PubMed : 24478229).

See full target information REEP1

style

left-column

文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Stem cell research 77:103378 PubMed38479332

2024

Generation of homozygous and heterozygous REEP1 knockout induced pluripotent stem cell lines by CRISPR/Cas9 gene editing.

Applications

Unspecified application

Species

Unspecified reactive species

M Korneck,A Leonhardt,L Schöls,S Hauser

Cell death & disease 12:42 PubMed33414446

2021

TRIB2 modulates proteasome function to reduce ubiquitin stability and protect liver cancer cells against oxidative stress.

Applications

Unspecified application

Species

Unspecified reactive species

Susu Guo,Yuxin Chen,Yueyue Yang,Xiao Zhang,Lifang Ma,Xiangfei Xue,Yongxia Qiao,Jiayi Wang

View all publications

style

left-column

style

left-column

style

right-column

Abcam Product Promise

我们致力于为您的研究提供高质量的试剂，为您科研的每一步提供支持。若我们的产品未能达到预期性能，我们向您提供 Abcam Product Promise 保障。

详情请参阅我们的条款与条件。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-REEP1抗体

Anti-REEP1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-REEP1 antibody (AB230026)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-REEP1 antibody (AB230026)

Western blot - Anti-REEP1 antibody (AB230026)