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AB242077

redFluor™ 710 Anti-CD62L抗体[MEL-14]

redFluor™ 710 Anti-CD62L antibody [MEL-14]

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Rat Monoclonal CD62L antibody - conjugated to redFluor™ 710. Suitable for Flow Cyt and reacts with Mouse samples. Immunogen corresponding to Cell preparation containing CD62L protein.
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Flow Cytometry - redFluor™ 710 Anti-CD62L antibody [MEL-14] (AB242077)
  • Flow Cyt

Supplier Data

Flow Cytometry - redFluor™ 710 Anti-CD62L antibody [MEL-14] (AB242077)

Flow Cytometric analysis of C57Bl/6 splenocytes staining CD62L using 0.5 μg ab242077 (solid line) or 0.5 μg redFluor™ 710 Rat IgG2a isotype control (dashed line).

不同偶联物与剂型 (6)

  • Unconjugated

    Anti-CD62L antibody [MEL-14]

  • 778 PE/Cy7®

    PE/Cy7® Anti-CD62L antibody [MEL-14]

  • Biotin

    Biotin Anti-CD62L antibody [MEL-14]

  • 519 FITC

    FITC Anti-CD62L antibody [MEL-14]

  • 660 APC

    APC Anti-CD62L antibody [MEL-14]

  • Carrier free

    Anti-CD62L antibody [MEL-14] - BSA and Azide free

关键信息

宿主种属

Rat

克隆

Monoclonal

克隆号

MEL-14

亚型

IgG2a

轻链类型

kappa

偶联物

redFluor™ 710

激发波长/发射波长
不含载体蛋白

No

反应种属

Mouse

应用

Flow Cyt

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<p>0.5 μg: The amount of antibody required for optimal staining of a cell sample should be determined empirically in your system.</p>" } } }
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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification
纯化说明
Purified from TCS.
存储溶液
pH: 7.2 Preservative: 0.09% Sodium azide Constituents: 0.87% Sodium chloride, 0.12% Sodium dihydrogen phosphate, 0.1% Gelatin
运输条件
Blue Ice
推荐的短期储存条件
+4°C
推荐的长期储存条件
+4°C
储存信息
Store in the dark
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

CD62L also known as L-selectin is a cell adhesion molecule with a mass of approximately 74 kDa. It is part of the L-selectin family and is found on the surface of leukocytes including T cells B cells neutrophils and monocytes. Mouse models frequently study CD62L under the name "MEL-14". CD62L plays an important role in mediating the adhesion and rolling of leukocytes on blood vessel endothelial cells during the immune response. Its structure allows it to interact specifically with carbohydrates on endothelial cells facilitating the initial steps of leukocyte extravasation into tissues.
Biological function summary

CD62L is involved in the migration of leukocytes into lymphoid tissues and sites of inflammation. It is not known to be part of a larger protein complex; rather it functions independently on the cell membrane. CD62L also assists in the homing of naive lymphocytes to peripheral lymph nodes. The molecule regulates how immune cells enter tissues through high endothelial venules acting as a critical entry point for leukocyte trafficking.

Pathways

CD62L contributes significantly to the immune trafficking pathway and leukocyte adhesion cascade. It works closely with other adhesion molecules like CD44 and CD54 (ICAM-1) which are important within the context of cellular responses during inflammation. CD62L's function in these pathways ensures that immune cells are properly directed to areas where they are needed most whether that is secondary lymphoid organs or inflamed tissues.

CD62L expression and function have been associated with inflammatory conditions and certain immune-related pathologies such as multiple sclerosis and rheumatoid arthritis. Altered CD62L expression can affect lymphocyte homing potentially playing a role in the pathogenesis of these conditions. The role of CD62L is also linked to proteins like CD44 which can modulate cell interactions and have overlapping functions in disease mechanisms influencing disease progression or resolution.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

See full target information CD62L
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Abcam Product Promise

我们致力于为您的研究提供高质量的试剂，为您科研的每一步提供支持。若我们的产品未能达到预期性能，我们向您提供 Abcam Product Promise 保障。
详情请参阅我们的条款与条件。
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