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AB181082

重组Anti-RBMS3+ RBMS1抗体[EPR12905]

Anti-RBMS3+ RBMS1 antibody [EPR12905]

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(1 Publication)

Rabbit Recombinant Monoclonal RBMS1 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication.

查看别名

C2orf12, MSSP, MSSP1, SCR2, RBMS1, Single-stranded DNA-binding protein MSSP-1, Suppressor of CDC2 with RNA-binding motif 2

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-RBMS3+ RBMS1 antibody [EPR12905] (AB181082)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-RBMS3+ RBMS1 antibody [EPR12905] (AB181082)

Immunofluorescent analysis of THP1 cells (-20 ° Acetone-fixed) labeling RBMS1 with ab181082 at 1/250 dilution. Secondary antibody Goat anti rabbit IgG (Dylight 488). Conterstained with Dapi (blue).

Western blot - Anti-RBMS3+ RBMS1 antibody [EPR12905] (AB181082)
  • WB

Supplier Data

Western blot - Anti-RBMS3+ RBMS1 antibody [EPR12905] (AB181082)

All lanes:

Western blot - Anti-RBMS3+ RBMS1 antibody [EPR12905] (ab181082) at 1/1000 dilution

Lane 1:

NIH:OVCAR-3 cell lysate at 20 µg

Lane 2:

HepG2 cell lysate at 20 µg

Lane 3:

THP1 cell lysate at 20 µg

Secondary

All lanes:

Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Predicted band size: 45 kDa,48 kDa

false

不同偶联物与剂型 (1)

  • Carrier free

    Anti-RBMS3+ RBMS1 antibody [EPR12905] - BSA and Azide free

关键信息

宿主种属

Rabbit

克隆

Monoclonal

克隆号

EPR12905

亚型

IgG

不含载体蛋白

No

反应种属

Human

应用

ICC/IF, WB

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

特异性

Immunogen also corresponds to amino acids 102 -114 of RBMS3 (Q6XE24).

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/2000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/100 - 1/250", "ICCIF-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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产品详情

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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性能和储存信息

形式
Liquid
纯度
Tissue culture supernatant
存储溶液
Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

RBMS3 and RBMS1 are members of the RNA-binding motif single-stranded interacting protein family known for their role in nucleic acid binding. RBMS3 often referred to as RNA-binding motif single-stranded-interacting protein 3 possesses a molecular mass of approximately 43 kDa. RBMS1 shares a similar domain structure targeted as an RNA-binding protein. These proteins express in various tissues including the liver heart and lungs with significant levels in the brain and kidneys. Both RBMS3 and RBMS1 play a part in regulating cellular proliferation and have been linked to the stabilization of specific mRNA transcripts.
Biological function summary

RBMS3 and RBMS1 take part in processes that impact cell growth apoptosis and differentiation. They involve themselves in RNA metabolism where they can influence mRNA stability and transcription. In terms of complex formation they associate with other factors to regulate transcription and influence gene expression. They help control genes involved in cellular growth responses and have implications for maintaining cellular homeostasis.

Pathways

RBMS3 and RBMS1 contribute to the regulation of the cell cycle and apoptosis. They participate in the Wnt signaling pathway a critical route for cell proliferation and fate determination. In connection with this pathway they interact with proteins such as beta-catenin which is essential for transmitting signals within the Wnt pathway. These proteins also influence other signaling cascades that affect cellular growth and differentiation.

RBMS3 and RBMS1 show significant influence in cancer and fibrosis. Their misregulation associates with oncogenic processes where they can contribute to abnormal cell proliferation linked to various cancers. They interact with p53 a well-known tumor suppressor protein whose pathway mutations are common in cancer types. RBMS3 and RBMS1 have been implicated in tissue fibrosis where improper cell growth and response lead to the pathological development of fibrotic tissues. Their expression patterns and interactions make them significant in understanding complex changes in diseased states.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

Single-stranded DNA binding protein that interacts with the region upstream of the MYC gene. Binds specifically to the DNA sequence motif 5'-[AT]CT[AT][AT]T-3'. Probably has a role in DNA replication.
See full target information RBMS1

其他靶点

RBMS3
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Nature cell biology 24:62-73 PubMed35013556

2022

The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin.

Applications

Unspecified application

Species

Unspecified reactive species

Dragomir B Krastev,Shudong Li,Yilun Sun,Andrew J Wicks,Gwendoline Hoslett,Daniel Weekes,Luned M Badder,Eleanor G Knight,Rebecca Marlow,Mercedes Calvo Pardo,Lu Yu,Tanaji T Talele,Jiri Bartek,Jyoti S Choudhary,Yves Pommier,Stephen J Pettitt,Andrew N J Tutt,Kristijan Ramadan,Christopher J Lord
View all publications
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搭配使用产品

Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB18203

Anti-N Cadherin antibody - Intercellular Junction Marker

BOND RX™ Validated|Lab Essentials

Western blot - Anti-N Cadherin antibody - Intercellular Junction Marker (AB18203)

  • 4
  • 48
Primary Antibodies

AB272612

Anti-RBMS3 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RBMS3 antibody (AB272612)

  • 0
  • 0
Primary Antibodies

AB32454

Anti-MAP2 antibody - Neuronal Marker

BOND RX™ Validated|Lab Essentials

Immunocytochemistry/ Immunofluorescence - Anti-MAP2 antibody - Neuronal Marker (AB32454)

  • 5
  • 35

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