Anti-RANTES抗体[VL1] (ab52562)
Key features and details
- Mouse monoclonal [VL1] to RANTES
- Suitable for: IHC-Fr, ELISA, IP, WB
- Reacts with: Human
- Isotype: IgG2b
概述
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产品名称
Anti-RANTES抗体[VL1]
参阅全部 RANTES 一抗 -
描述
小鼠单克隆抗体[VL1] to RANTES -
宿主
Mouse -
特异性
Recognizes natural and recombinant human RANTES. -
经测试应用
适用于: IHC-Fr, ELISA, IP, WBmore details -
种属反应性
与反应: Human -
免疫原
Recombinant full length protein (Human)
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常规说明
This antibody is useful for studies involving inhibition of chemotaxis and immunostaining of cryostat sections and cytospins.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
存储溶液
Constituent: PBS
The addition of a preservative, such as 0.1% sodium azide, is recommended for long term storage. -
Concentration information loading... -
纯度
Protein A purified -
纯化说明
Sterile filtered (0.22 micron). >95% by SDS-PAGE analysis. -
Primary antibody说明
This antibody is useful for studies involving inhibition of chemotaxis and immunostaining of cryostat sections and cytospins. -
克隆
单克隆 -
克隆编号
VL1 -
同种型
IgG2b -
轻链类型
kappa -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab52562于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| IHC-Fr | (1) |
Use at an assay dependent concentration.
|
| ELISA |
Use at an assay dependent concentration.
|
|
| IP |
Use at an assay dependent concentration.
|
|
| WB |
Use at an assay dependent concentration.
|
| 说明 |
|---|
|
IHC-Fr
Use at an assay dependent concentration. |
|
ELISA
Use at an assay dependent concentration. |
|
IP
Use at an assay dependent concentration. |
|
WB
Use at an assay dependent concentration. |
靶标
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功能
Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. Binds to CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils. -
组织特异性
T-cell and macrophage specific. -
序列相似性
Belongs to the intercrine beta (chemokine CC) family. -
翻译后修饰
N-terminal processed form RANTES(3-68) is produced by proteolytic cleavage, probably by DPP4, after secretion from peripheral blood leukocytes and cultured sarcoma cells.
The identity of the O-linked saccharides at Ser-27 and Ser-28 are not reported in PubMed:1380064. They are assigned by similarity. -
细胞定位
Secreted. - Information by UniProt
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数据库链接
- Entrez Gene: 6352 Human
- Omim: 187011 Human
- SwissProt: P13501 Human
- Unigene: 514821 Human
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别名
- Beta chemokine RANTES antibody
- Beta chemokine RANTES precursor antibody
- C C motif chemokine 5 antibody
see all
实验方案
数据表及文件
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Datasheet download
文献 (1)
ab52562 被引用在 1 文献中.
- de Souza A et al. Resolution of CD8+ lymphomatoid papulosis after surgical excision of the type AB-thymoma. Am J Dermatopathol 31:475-9 (2009). PubMed: 19542925
