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AB95202

Anti-RAET1E抗体[79/6/13/16]

Anti-RAET1E antibody [79/6/13/16]

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(5 Publications)

Mouse Monoclonal RAET1E antibody. Suitable for IP, Flow Cyt, ELISA, WB, FuncS (Neut/Block), ICC/IF and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Recombinant Fragment Protein within Human RAET1E aa 1-250.

查看别名

LETAL, N2DL4, ULBP4, UNQ1867/PRO4303, RAET1E, Retinoic acid early transcript 1E, Lymphocyte effector toxicity activation ligand, NKG2D ligand 4, RAE-1-like transcript 4, UL16-binding protein 4, N2DL-4, NKG2DL4

关键信息

宿主种属

Mouse

克隆

Monoclonal

克隆号

79/6/13/16

亚型

IgG2a

不含载体蛋白

No

反应种属

Human

应用

FuncS (Neut/Block), WB, IP, Flow Cyt, ELISA, ICC/IF

applications

免疫原

Recombinant Fragment Protein within Human RAET1E aa 1-250. The exact immunogen used to generate this antibody is proprietary information.

Q8TD07

反应性数据

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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Protein A/G
存储溶液
Preservative: 0.02% Sodium azide Constituents: PBS
运输条件
Blue Ice
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

RAET1E also known as UL16-binding protein 4 (ULBP4) is a member of the MHC class I-related molecules. It has a molecular mass of approximately 31 kDa. RAET1E is part of the family of proteins that acts as a ligand for the NKG2D receptor found on the surface of natural killer (NK) cells. In terms of expression RAET1E is present on the surface of various cell types especially in stressed transformed or virus-infected cells where it signals cellular distress to immune cells.
Biological function summary

RAET1E plays a role in immune surveillance. It is involved in the activation of NK cells when it binds to the NKG2D receptor. This interaction is part of the body's defense mechanism against transformed or infected cells. RAET1E operates in isolation rather than as part of a larger protein complex which allows it to independently initiate the immune response when detecting harmful cells.

Pathways

RAET1E functions within the innate immune response pathway. It works closely with the NKG2D signaling pathway which is important for the activation of cytotoxic activities in immune cells. RAET1E through its binding to NKG2D facilitates the destruction of malignant cells. This connection places RAET1E alongside other similar NKG2D ligands such as MIC and other ULBP family proteins which contribute to the activation of NK and T cells.

RAET1E is linked to various cancer types and infectious diseases. Its expression on the surface of tumor cells can signal NK cells to target and destroy these potentially harmful cells. In certain cancers the loss or reduction of RAET1E expression may allow tumor cells to escape immune detection. In viral infections the upregulation of RAET1E on infected cells assists in the clearance of viruses by NK cells. Both in cancer and viral infections proteins like RAET1E and NKG2D play an important part in the immune system's defensive strategies.

产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

靶点信息

Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.
See full target information RAET1E

文献 (5)

Recent publications for all applications. Explore the full list and refine your search

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 10:e2202519 PubMed36683155

2023

Metabolic Reprogramming of NK Cells by Black Phosphorus Quantum Dots Potentiates Cancer Immunotherapy.

Applications

Unspecified application

Species

Unspecified reactive species

Lizhen He,Jianfu Zhao,Hongjun Li,Bin Xie,Ligeng Xu,Guanning Huang,Ting Liu,Zhen Gu,Tianfeng Chen

Helicobacter 26:e12812 PubMed33928707

2021

Heat-killed Helicobacter pylori upregulates NKG2D ligands expression on gastric adenocarcinoma cells via Toll-like receptor 4.

Applications

Unspecified application

Species

Unspecified reactive species

Carolina Hernández,Karen Toledo-Stuardo,Paulina García-González,Macarena Garrido-Tapia,Karina Kramm,José Alejandro Rodríguez-Siza,Marcela Hermoso,Carolina H Ribeiro,María Carmen Molina

Oncoimmunology 9:1746148 PubMed32363114

2020

Targeting ubiquitin protein ligase E3 component N-recognin 5 in cancer cells induces a CD8+ T cell mediated immune response.

Applications

Unspecified application

Species

Unspecified reactive species

Mei Song,Chao Wang,Huan Wang,Tuo Zhang,Jiuqi Li,Robert Benezra,Lotfi Chouchane,Yin-Hao Sun,Xin-Gang Cui,Xiaojing Ma

Oncoimmunology 6:e1358839 PubMed29147621

2017

In-depth immunophenotyping of patients with glioblastoma multiforme: Impact of steroid treatment.

Applications

Unspecified application

Species

Unspecified reactive species

Guranda Chitadze,Charlotte Flüh,Elgar Susanne Quabius,Sandra Freitag-Wolf,Christian Peters,Marcus Lettau,Jaydeep Bhat,Daniela Wesch,Hans-Heinrich Oberg,Stefanie Luecke,Ottmar Janssen,Michael Synowitz,Janka Held-Feindt,Dieter Kabelitz

International journal of cancer 135:1390-8 PubMed24615495

2014

Therapeutic potential of highly cytotoxic natural killer cells for gastric cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Kousaku Mimura,Takahiro Kamiya,Kensuke Shiraishi,Ley-Fang Kua,Asim Shabbir,Jimmy So,Wei-Peng Yong,Yoshiyuki Suzuki,Yuya Yoshimoto,Takashi Nakano,Hideki Fujii,Dario Campana,Koji Kono
View all publications

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