AB201322

Anti-PXMP2/PMP22抗体

Name: PXMP2/PMP22抗体 (ab201322)| Abcam中文官网
Brand: Abcam Limited
SKU: AB201322
Price: 4606 CNY
Availability: InStock

Anti-PXMP2/PMP22 antibody

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(1 Publication)

Rabbit Polyclonal PXMP2/PMP22 antibody. Suitable for WB and reacts with Human, Rat samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human PXMP2 aa 1-100.

查看别名

PMP22, PXMP2, Peroxisomal membrane protein 2, 22 kDa peroxisomal membrane protein

1 Images

Supplier Data

Western blot - Anti-PXMP2/PMP22 antibody (AB201322)

All lanes:

Western blot - Anti-PXMP2/PMP22 antibody (ab201322)

Lane 1:

A549 whole cell lysate

Lane 2:

PC12 whole cell lysate

Predicted band size: 22 kDa

false

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Rat, Human

应用

applications

免疫原

Synthetic Peptide within Human PXMP2 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.

Q9NR77

特异性

Detects endogenous levels of PXMP2/Gbf1 protein.

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500", "WB-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500", "WB-species-notes": "<p></p>" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

纯化说明

Purity is > 95% (by SDS-PAGE).

存储溶液

pH: 7.3 Preservative: 0.05% Sodium azide Constituents: PBS

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

The PXMP2/PMP22 protein also known as Peripheral Myelin Protein 22 has an important role in maintaining membrane structures and functions. Its molecular weight is approximately 22 kDa. This protein is mainly found in Peripheral Nervous System (PNS) Schwann cells and to a lesser extent in other tissues. It integrates into the peroxisomal membrane and participates in forming membrane channels that are essential for peroxisomal function. PXMP2/PMP22 influences the structural integrity and permeability of the membrane allowing various small molecules to pass which is essential for maintaining cell homeostasis.

Biological function summary

PXMP2/PMP22 supports the development and maintenance of myelin the protective sheath around nerve fibers that ensures efficient nerve signal transmission. It is an important component of the compact myelin structure. In Schwann cells PXMP2/PMP22 works as part of a complex network of proteins that coordinate to regulate cellular functions necessary for myelin sheath formation and repair. This protein's role in maintaining myelin integrity is integral to the normal functioning of the nervous system.

Pathways

PXMP2/PMP22 is integral to the myelination pathway which involves the assembly and preservation of myelin sheathing nerve fibers. It interacts with other myelin-associated proteins such as Connexin 32 and Myelin Protein Zero. These interactions ensure coordinated development and repair of the myelin sheath which is vital for rapid nerve impulse transmission. Another significant pathway involving PXMP2/PMP22 includes lipid metabolism in which it aids peroxisomal transport processes necessary for breaking down lipid molecules.

PXMP2/PMP22 has connections to Charcot-Marie-Tooth disease type 1A (CMT1A) a hereditary neuropathy characterized by progressive muscle weakness and sensory loss. Alterations in the expression of the PXMP2/PMP22 gene including duplication cause disruptions in normal myelin function leading to the development of CMT1A symptoms. Additionally abnormal PXMP2/PMP22 expression associates with Dejerine-Sottas syndrome revealing its critical role in maintaining myelin integrity. The protein's dysfunction in these diseases further highlights its importance in myelin stability and nerve function.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Seems to be involved in pore-forming activity and may contribute to the unspecific permeability of the peroxisomal membrane.

See full target information PXMP2

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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

EMBO molecular medicine 14:e14485 PubMed34826211

2021

SPINK6 inhibits human airway serine proteases and restricts influenza virus activation.

Applications

Unspecified application

Species

Unspecified reactive species

Dong Wang,Cun Li,Man Chun Chiu,Yifei Yu,Xiaojuan Liu,Xiaoyu Zhao,Jingjing Huang,Zhongshan Cheng,Shuofeng Yuan,Vincent Poon,Jian-Piao Cai,Hin Chu,Jasper Fuk-Woo Chan,Kelvin Kai-Wang To,Kwok Yung Yuen,Jie Zhou

View all publications

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Anti-PXMP2/PMP22抗体

Anti-PXMP2/PMP22 antibody

Western blot - Anti-PXMP2/PMP22 antibody (AB201322)

关键信息

宿主种属

克隆

亚型

不含载体蛋白

反应种属

应用

免疫原

特异性