Anti-Pur B抗体(ab130999)
Key features and details
- Rabbit polyclonal to Pur B
- Suitable for: IP
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-Pur B抗体 -
描述
兔多克隆抗体to Pur B -
宿主
Rabbit -
经测试应用
适用于: IPmore details -
种属反应性
与反应: Human
预测可用于: Mouse, Rat, Cow, Dog, Pig, Chimpanzee, Ferret, Rhesus monkey, Gorilla, Chinese hamster, Orangutan
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免疫原
Synthetic peptide, corresponding to a region between amino acids 262-312 of Human Pur B (NP_150093.1).
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阳性对照
- Jurkat whole cell lysate (ab7899).
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C. -
存储溶液
pH: 7
Preservative: 0.09% Sodium azide
Constituent: 99% Tris citrate/phosphate
pH 7 to 8 -
Concentration information loading... -
纯度
Immunogen affinity purified -
纯化说明
ab130999 is affinity purified using an epitope specific to Pur B immobilized on solid support. -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab130999于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| IP |
Use at 2-10 µg/mg of lysate.
|
| 说明 |
|---|
|
IP
Use at 2-10 µg/mg of lysate. |
靶标
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功能
Has capacity to bind repeated elements in single-stranded DNA such as the purine-rich single strand of the PUR element located upstream of the MYC gene. Plays a role in the control of vascular smooth muscle (VSM) alpha-actin gene transcription as repressor in myoblasts and fibroblasts. Participates in transcriptional and translational regulation of alpha-MHC expression in cardiac myocytes by binding to the purine-rich negative regulatory (PNR) element. Modulates constitutive liver galectin-3 gene transcription by binding to its promoter. May play a role in the dendritic transport of a subset of mRNAs. -
组织特异性
Expressed in myocardium of heart failure patients. -
序列相似性
Belongs to the PUR DNA-binding protein family. -
翻译后修饰
Phosphorylated upon DNA damage, probably by ATM or ATR. -
细胞定位
Nucleus. - Information by UniProt
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数据库链接
- Entrez Gene: 5814 Human
- Entrez Gene: 19291 Mouse
- Entrez Gene: 498407 Rat
- Omim: 608887 Human
- SwissProt: Q96QR8 Human
- SwissProt: O35295 Mouse
- SwissProt: Q68A21 Rat
- Unigene: 596321 Human
see all -
别名
- Pur beta antibody
- purB antibody
- PURB_HUMAN antibody
see all
图片
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Immunoprecipitation - Anti-Pur B antibody (ab130999)Detection of Pur B by Western Blot of Immunprecipitate.
ab130999 at 1µg/ml staining Pur B in Jurkat whole cell lysate immunoprecipitated using ab1130999 at 6µg/mg lysate (1 mg/IP; 20% of IP loaded/lane).
Detection: Chemiluminescence with exposure time of 3 minutes.
数据表及文件
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SDS download
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Datasheet download
文献 (0)
ab130999 尚未被引用在任何文献中。