AB168479

Anti-PTPMT1抗体

Name: PTPMT1抗体 (ab168479)| Abcam中文官网
Brand: Abcam Limited
SKU: AB168479
Price: 4606 CNY
Availability: InStock

Anti-PTPMT1 antibody

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(1 Publication)

Mouse Polyclonal PTPMT1 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human PTPMT1.

查看别名

MOSP, PLIP, PNAS-129, PTPMT1, Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1, PTEN-like phosphatase, Phosphoinositide lipid phosphatase, Protein-tyrosine phosphatase mitochondrial 1

1 Images

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Western blot - Anti-PTPMT1 antibody (AB168479)

All lanes:

Western blot - Anti-PTPMT1 antibody (ab168479) at 1 µg/mL

Lane 1:

PTPMT1 transfected 293T cell lysate at 15 µL

Lane 2:

Non-transfected 293T cell lysate at 15 µL

Predicted band size: 23 kDa

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关键信息

宿主种属

Mouse

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Human

应用

applications

免疫原

Recombinant Full Length Protein corresponding to Human PTPMT1.

Q8WUK0

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Protein A

存储溶液

pH: 7.4 Constituents: PBS

运输条件

Blue Ice

分装信息

Upon delivery aliquot

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

PTPMT1 also known as protein tyrosine phosphatase mitochondrial 1 has a molecular mass of approximately 23 kDa. This protein is a unique phosphatase localized to the mitochondria. It specifically dephosphorylates phosphatidylinositol phosphates and plays a critical role in mitochondrial function. PTPMT1 is expressed highly in tissues with significant energy demands like the heart and skeletal muscle suggesting its role in energy metabolism.

Biological function summary

A phosphatase that is involved in important tasks within the mitochondria PTPMT1 contributes significantly to the regulation of mitochondrial metabolism. It removes phosphate groups from target substrates which is essential for the biosynthesis of cardiolipin an important lipid in mitochondrial membrane composition. Although not formally part of a large complex it interacts closely with other mitochondrial enzymes to maintain lipid homeostasis.

Pathways

Lipid metabolism and insulin signaling both involve PTPMT1. It mediates its actions through the biosynthesis of phosphatidylinositol derivatives that influence the insulin signaling pathway. It has a connection with the PI3K/Akt signaling cascade affecting the actions of proteins such as Akt and PDK1 which play integral roles in cellular energy balance and glucose homeostasis.

Improper PTPMT1 function relates closely to metabolic disorders particularly diabetes mellitus. PTPMT1 activity affects insulin signaling and its dysregulation contributes to insulin resistance. There is also an association with mitochondrial dysfunction which may lead to neurodegenerative disorders. In these contexts PTPMT1's interaction with proteins like insulin receptor substrate (IRS) can provide avenues to study therapeutic targets for related diseases.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) (By similarity). PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the membrane integrity and activities of the organelle (PubMed : 39279645). Has also been shown to display phosphatase activity toward phosphoprotein substrates, specifically mediates dephosphorylation of mitochondrial proteins, thereby playing an essential role in ATP production (By similarity). Has probably a preference for proteins phosphorylated on Ser and/or Thr residues compared to proteins phosphorylated on Tyr residues (By similarity). Probably involved in regulation of insulin secretion in pancreatic beta cells (By similarity). Prevents intrinsic apoptosis, by regulating mitochondrial membrane integrity (PubMed : 24709986, PubMed : 39279645).

See full target information PTPMT1

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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Acta biochimica Polonica 69:417-422 PubMed35696596

2022

USP18 contributes to the proliferation and migration of ovarian cancer cells by regulating the AKT/mTOR signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Meiqin Liu,Shile Gao,Xingjun Xu,Lijie Zhang,Bin Xu,Donghui Lu

View all publications

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Anti-PTPMT1抗体

Anti-PTPMT1 antibody

Western blot - Anti-PTPMT1 antibody (AB168479)