AB109118

重组Anti-PTP4A2/PRL2抗体[EPR3800]

Anti-PTP4A2/PRL2 antibody [EPR3800]

RabMAb
Recombinant
了解详情

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(2 Publications)

Rabbit Recombinant Monoclonal PTP4A2/PRL2 antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications.

查看别名

PRL2, PTPCAAX2, BM-008, PTP4A2, Protein tyrosine phosphatase type IVA 2, HU-PP-1, OV-1, PTP(CAAXII), Protein-tyrosine phosphatase 4a2, Protein-tyrosine phosphatase of regenerating liver 2, PRL-2

1 Images

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Western blot - Anti-PTP4A2/PRL2 antibody [EPR3800] (AB109118)

All lanes:

Western blot - Anti-PTP4A2/PRL2 antibody [EPR3800] (ab109118) at 1/1000 dilution

Lane 1:

SW480 cell lysate at 10 µg

Lane 2:

SKBR-3 cell lysate at 10 µg

Lane 3:

A549 cell lysate at 10 µg

Lane 4:

HeLa cell lysate at 10 µg

Predicted band size: 19 kDa

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关键信息

宿主种属

Rabbit

克隆

Monoclonal

克隆号

EPR3800

亚型

IgG

不含载体蛋白

反应种属

Human

应用

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

特异性

The immunogen used for this product shares 71% identity (78% positives) with PRL-1. Cross-reactivity with this protein has not been confirmed experimentally.

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反应性数据

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产品详情

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Protein A

存储溶液

pH: 7.2 - 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 9.85% Tris glycine, 0.1% BSA

运输条件

Blue Ice

储存信息

Stable for 12 months at -20°C

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

PTP4A2 also known as PRL2 is a protein tyrosine phosphatase with a mass of approximately 19 kDa. It functions by catalyzing the removal of phosphate groups from tyrosine residues on proteins which regulates various cellular processes. PTP4A2 is expressed in a range of tissues including the liver brain and heart. Its expression has been noted to increase in certain types of cancer suggesting its involvement in tumorigenesis.

Biological function summary

PTP4A2 regulates cell growth migration and invasion. It participates in several biological processes by modulating signaling pathways that control these activities. PTP4A2 does not traditionally form part of a larger protein complex but interacts with other proteins to exert its effects. It is important in normal cellular proliferation and differentiation.

Pathways

PTP4A2 plays a role in the MAPK signaling pathway and interacts with proteins such as ERK1 and ERK2. It is also involved in the PI3K/AKT pathway affecting cell survival and metabolism. Through these pathways PTP4A2 modulates various cellular responses influencing both normal physiological processes and pathological conditions.

PTP4A2 shows a significant link to cancer particularly breast and prostate cancers. This protein influences disease progression via alterations in related signaling pathways. PTP4A2 connections to oncogenes like c-Myc highlight its role in tumor development and progression. Its activity in these contexts makes it a potential therapeutic target for cancer treatment strategies.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Promotes tumors. Inhibits geranylgeranyl transferase type II activity by blocking the association between RABGGTA and RABGGTB.

See full target information PTP4A2

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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Materials today. Bio 35:102287 PubMed40989834

2025

Photothermal-triggered NO-releasing nanofiber membrane mitigates intervertebral disc degeneration via inflammation inhibition and matrix stabilization.

Applications

Unspecified application

Species

Unspecified reactive species

Guanfeng Huang,Jiajun Xie,Jialan Chen,Jiangminghao Zhao,Pinkai Wang,Jian Zhang,Peichuan Xu,Yang Li,Xiaolong Chen,Xinxin Miao,Wei Xiong,Xigao Cheng

Computational and mathematical methods in medicine 2021:4439505 PubMed34992672

2021

Downregulated Expression of miRNA-130a-5p Aggravates Hepatoma Progression via Targeting PTP4A2.

Applications

Unspecified application

Species

Unspecified reactive species

Longqing Shi,Fengbo Wang,Yue Zhang,Yue Yang,Zheng Qu,Donglin Sun

View all publications

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Abcam Product Promise

我们致力于为您的研究提供高质量的试剂，为您科研的每一步提供支持。若我们的产品未能达到预期性能，我们向您提供 Abcam Product Promise 保障。

详情请参阅我们的条款与条件。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

重组Anti-PTP4A2/PRL2抗体[EPR3800]

Anti-PTP4A2/PRL2 antibody [EPR3800]

Western blot - Anti-PTP4A2/PRL2 antibody [EPR3800] (AB109118)

关键信息

宿主种属

克隆

克隆号

亚型

不含载体蛋白

反应种属

应用

免疫原

特异性