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AB169769

重组Anti-PTP alpha (phospho Y798)抗体[EPR10369]

Anti-PTP alpha (phospho Y798) antibody [EPR10369]

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(1 Publication)

Rabbit Recombinant Monoclonal PTP alpha phospho Y798 antibody. Suitable for WB and reacts with Rat samples. Cited in 1 publication.

查看别名

PTPA, PTPRL2, PTPRA, Receptor-type tyrosine-protein phosphatase alpha, Protein-tyrosine phosphatase alpha, R-PTP-alpha

1 Images
Western blot - Anti-PTP alpha (phospho Y798) antibody [EPR10369] (AB169769)
  • WB

Unknown

Western blot - Anti-PTP alpha (phospho Y798) antibody [EPR10369] (AB169769)

All lanes:

Western blot - Anti-PTP alpha (phospho Y798) antibody [EPR10369] (ab169769) at 1/1000 dilution

Lane 1:

C6 cell lysate, untreated at 10 µg

Lane 2:

C6 cell lysate, treated with AP at 10 µg

Secondary

All lanes:

HRP labeled goat anti-rabbit at 1/2000 dilution

Predicted band size: 91 kDa

false

关键信息

宿主种属

Rabbit

克隆

Monoclonal

克隆号

EPR10369

亚型

IgG

不含载体蛋白

No

反应种属

Rat

应用

WB

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Mouse": { "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>", "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" } } }
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产品详情

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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性能和储存信息

形式
Liquid
纯度
Tissue culture supernatant
存储溶液
pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 9% PBS, 0.05% BSA
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Protein Tyrosine Phosphatase Alpha (PTP alpha) also known as PTPRA serves as an enzyme that removes phosphate groups from specific tyrosine residues on proteins. It has an approximate molecular weight of 130 kDa. PTP alpha is located in the cell membrane and shows expression in various tissues including the brain liver and skeletal muscle. It functions as a signaling molecule that modifies the activity of several proteins playing a significant role in cell growth differentiation and mitosis.
Biological function summary

PTPRA influences cellular processes by serving as a regulator of the Src family of tyrosine kinases which are important for intracellular signal transduction. PTP alpha does not form part of a complex but rather exists as a monomer although it can interact with other proteins. Its activity helps maintain the balance of phosphorylation and dephosphorylation which is essential for cellular signaling homeostasis.

Pathways

PTP alpha acts in the integrin and growth factor receptor signaling pathways. It plays a role in integrin signaling by dephosphorylating substrates that modulate cell adhesion and migration. Additionally in growth factor receptor signaling PTP alpha modulates cell proliferation by interacting with substrates such as the epidermal growth factor receptor (EGFR). It shares pathway links with proteins like SRC and FAK emphasizing its regulatory role over them.

PTP alpha has associations with cancer particularly in cases such as colorectal and breast cancer. It affects cancer progression by modifying signaling involved in uncontrolled cell growth. Furthermore PTPRA has findings connecting it with neurodegenerative diseases like Alzheimer's through its effect on signaling cascades that involve amyloid precursor protein (APP). In these contexts PTP alpha’s interactions with proteins such as EGFR and FAK reveal its significance in disease pathology.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

Tyrosine protein phosphatase which is involved in integrin-mediated focal adhesion formation (By similarity). Following integrin engagement, specifically recruits BCAR3, BCAR1 and CRK to focal adhesions thereby promoting SRC-mediated phosphorylation of BRAC1 and the subsequent activation of PAK and small GTPase RAC1 and CDC42 (By similarity).
See full target information PTPRA phospho Y798
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Cancers 13: PubMed34439388

2021

Quantitative Tyrosine Phosphoproteome Profiling of AXL Receptor Tyrosine Kinase Signaling Network.

Applications

Unspecified application

Species

Unspecified reactive species

Xinyan Wu,Li Wang,Nicole A Pearson,Santosh Renuse,Ran Cheng,Ye Liang,Dong-Gi Mun,Anil K Madugundu,Yaoyu Xu,Parkash S Gill,Akhilesh Pandey
View all publications
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Abcam Product Promise

我们致力于为您的研究提供高质量的试剂，为您科研的每一步提供支持。若我们的产品未能达到预期性能，我们向您提供 Abcam Product Promise 保障。
详情请参阅我们的条款与条件。
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