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Signal Transduction Metabolism Amino Acids

Anti-PSMD1抗体(ab2941)

  • Datasheet
  • SDS
Submit a review Q&A (3)References (7)

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Western blot - Anti-PSMD1 antibody (ab2941)

    Key features and details

    • Rabbit polyclonal to PSMD1
    • Suitable for: WB
    • Reacts with: Mouse, Rat, Human, African green monkey
    • Isotype: IgG

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    概述

    • 产品名称

      Anti-PSMD1抗体
      参阅全部 PSMD1 一抗
    • 描述

      兔多克隆抗体to PSMD1
    • 宿主

      Rabbit
    • 特异性

      Detects proteasome Rpn2 from human cells.
    • 经测试应用

      适用于: WBmore details
    • 种属反应性

      与反应: Mouse, Rat, Human, African green monkey
      预测可用于: Chicken
    • 免疫原

      Synthetic peptide corresponding to Human PSMD1 aa 929-953.
      Sequence:

      AAHGPKIEEEEQEPEPPEPFEYIDD

      Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI
    • 常规说明

      The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

      If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

    性能

    • 形式

      Liquid
    • 存放说明

      Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
    • 存储溶液

      Preservative: 0.05% Sodium azide
      Constituents: 0.1% BSA, 99% PBS
    • Concentration information loading...
    • 纯度

      Immunogen affinity purified
    • 克隆

      多克隆
    • 同种型

      IgG
    • 研究领域

      • Signal Transduction
      • Metabolism
      • Amino Acids
      • Cell Biology
      • Proteolysis / Ubiquitin
      • Proteasome / Ubiquitin
      • Proteasome

    相关产品

    • Compatible Secondaries

      • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
      • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
    • Isotype control

      • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)

    应用

    The Abpromise guarantee

    Abpromise™承诺保证使用ab2941于以下的经测试应用

    “应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。

    应用 Ab评论 说明
    WB
    Use a concentration of 1 µg/ml. Detects a band of approximately 105 kDa (predicted molecular weight: 105 kDa).

    By Western blot, this antibody detects an ~105 kDa protein representing proteasome 19S subunit S1 from HeLa cell extract.

    说明
    WB
    Use a concentration of 1 µg/ml. Detects a band of approximately 105 kDa (predicted molecular weight: 105 kDa).

    By Western blot, this antibody detects an ~105 kDa protein representing proteasome 19S subunit S1 from HeLa cell extract.

    靶标

    • 功能

      Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
    • 序列相似性

      Belongs to the proteasome subunit S1 family.
      Contains 10 PC repeats.
    • Target information above from: UniProt accession Q99460 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • 数据库链接

      • Entrez Gene: 424926 Chicken
      • Entrez Gene: 5707 Human
      • Entrez Gene: 70247 Mouse
      • Entrez Gene: 83806 Rat
      • SwissProt: Q5F418 Chicken
      • SwissProt: Q99460 Human
      • SwissProt: Q3TXS7 Mouse
      • SwissProt: O88761 Rat
      • Unigene: 3887 Human
      • Unigene: 280013 Mouse
      • Unigene: 2891 Rat
      see all
    • 别名

      • MGC133041 antibody
      • 26S proteasome non ATPase regulatory subunit 1 antibody
      • 26S proteasome non ATPase subunit 1 antibody
      • 26S proteasome non-ATPase regulatory subunit 1 antibody
      • 26S proteasome regulatory subunit rpn2 antibody
      • 26S proteasome regulatory subunit S1 antibody
      • 26S proteasome subunit p112 antibody
      • MGC133040 antibody
      • P112 antibody
      • Proteasome (prosome macropain) 26S subunit, non ATPase 1 antibody
      • Psmd1 antibody
      • PSMD1_HUMAN antibody
      • RPN2 antibody
      • S1 antibody
      see all

    图片

    • Western blot - Anti-PSMD1 antibody (ab2941)
      Western blot - Anti-PSMD1 antibody (ab2941)
      All lanes : Anti-PSMD1 antibody (ab2941) at 1 µg/ml

      Lane 1 : MCF7 cell lysate
      Lane 2 : PC-3 cell lysate
      Lane 3 : HepG2 cell lysate
      Lane 4 : SK-OV-3 cell lysate
      Lane 5 : HeLa cell lysate
      Lane 6 : COS-7 cell lysate
      Lane 7 : Jurkat cell lysate
      Lane 8 : A431 cell lysate
      Lane 9 : Mouse testis tissue lysate
      Lane 10 : Rat testis tissue lysate

      Lysates/proteins at 30 µg per lane.

      Secondary
      All lanes : Goat anti-Rabbit IgG (H+L) Superclonal™ HRP conjugate at 1/2500 dilution

      Developed using the ECL technique.

      Predicted band size: 105 kDa
      Observed band size: 106 kDa why is the actual band size different from the predicted?

    实验方案

    • Immunohistochemistry protocols
    • Immunocytochemistry & immunofluorescence protocols
    • Western blot protocols

    Click here to view the general protocols

    数据表及文件

    • SDS download

    • Datasheet download

      Download

    文献 (7)

    发表研究结果有使用 ab2941?请让我们知道,以便我们可以引用本数据表中的参考文章。

    ab2941 被引用在 7 文献中.

    • Dekel E  et al. 20S proteasomes secreted by the malaria parasite promote its growth. Nat Commun 12:1172 (2021). PubMed: 33608523
    • Olshina MA  et al. Regulation of the 20S Proteasome by a Novel Family of Inhibitory Proteins. Antioxid Redox Signal 32:636-655 (2020). PubMed: 31903784
    • Osei-Amponsa V  et al. Impact of Losing hRpn13 Pru or UCHL5 on Proteasome Clearance of Ubiquitinated Proteins and RA190 Cytotoxicity. Mol Cell Biol 40:N/A (2020). PubMed: 32631902
    • Bhat K  et al. Serum erythropoietin levels, breast cancer and breast cancer-initiating cells. Breast Cancer Res 21:17 (2019). PubMed: 30700319
    • Chen X  et al. Structure of hRpn10 Bound to UBQLN2 UBL Illustrates Basis for Complementarity between Shuttle Factors and Substrates at the Proteasome. J Mol Biol 431:939-955 (2019). PubMed: 30664872
    • Lu X  et al. Structure of the Rpn13-Rpn2 complex provides insights for Rpn13 and Uch37 as anticancer targets. Nat Commun 8:15540 (2017). PubMed: 28598414
    • Moscovitz O  et al. The Parkinson's-associated protein DJ-1 regulates the 20S proteasome. Nat Commun 6:6609 (2015). WB . PubMed: 25833141

    客户评价及客户问答

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    1-3 of 3 Abreviews or Q&A

    Question

    What is the concentration? Abcam lot# 119084

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    Abcam community

    Verified customer

    Asked on Sep 09 2005

    Answer

    Thank you for your phone call. The concentration is 1 mg/ml. If you have any additional questions, please let us know. Have a great weekend!

    Read More

    Abcam Scientific Support

    回复于 Sep 09 2005

    Question

    I was wondering if this antibody has been successfully tested in immunoprecipitation assays. Thanks.

    Read More

    Abcam community

    Verified customer

    Asked on Jan 25 2005

    Answer

    Thanks for your enquiry. To our knowledge, this antibody has yet to be tested in IP. All tested applications are specified on Abcam product datasheets. If you decide to go ahead and purchase this product, please let us know how you get on and in return we will award you 50 points with the Abcam Loyalty Scheme which can be redeemed on a number of rewards. If you have any additional questions, please let us know.

    Read More

    Abcam Scientific Support

    回复于 Jan 25 2005

    Question

    I would like to know if the proteasome 19S antibody ab2941 could work with rat brain slices, because we would like to study the proteasome expression by immunohistochemistry. you claim it works with human and cow tissues.

    Read More

    Abcam community

    Verified customer

    Asked on Dec 04 2003

    Answer

    All the information we have on species cross reactivity is specified on the datasheet. To our knowledge, cross reactivity with rat has not yet been tested. Should you decide to go ahead and purchase this product, please let us know how you get on and in return we will forward a reward of your choice, typically an Amazon gift voucher. If you have any more questions, please contact us again.

    Read More

    Abcam Scientific Support

    回复于 Dec 04 2003

    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
    For licensing inquiries, please contact partnerships@abcam.com

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