Anti-Pseudorabies Virus抗体

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

The Pseudorabies virus infects a wide range of mammalian hosts but swine are its primary reservoir. The virus replicates in the nucleus of host cells causing lytic infection processes. It does not form part of a complex but utilizes several proteins encoded in its genome to facilitate replication cell-to-cell spread and immune evasion. Once inside the host PRV establishes latency in peripheral nervous tissues and can reactivate leading to secondary infections.

Pathways

Several important cellular pathways interact with the Pseudorabies virus. Notably the virus manipulates the mitogen-activated protein kinase (MAPK) pathway to evade the host's immune response while enhancing its own replication process. The PRV modulates the expression and function of the p38 MAPK protein. Another key pathway involved is the JNK signaling pathway which affects viral replication and cell apoptosis. These interactions highlight how PRV proteins contribute to maintaining infection and influencing cellular responses.