重组Anti-PSD95 (phospho T19)抗体[EPR2619(2)] (ab172628)
![Western blot - Anti-PSD95 (phospho T19) antibody [EPR2619(2)] (ab172628)](https://www.abcam.cn/ps/products/172/ab172628/Images/ab172628-196029-anti-psd95-phospho-t19-antibody-epr26192-western-blot.jpg "Western blot - Anti-PSD95 (phospho T19) antibody [EPR2619(2)] (ab172628)")
Key features and details
- Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
- Rabbit monoclonal [EPR2619(2)] to PSD95 (phospho T19)
- Suitable for: WB
- Reacts with: Human
Related conjugates and formulations
概述
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产品名称
Anti-PSD95 (phospho T19)抗体[EPR2619(2)]
参阅全部 PSD95 一抗 -
描述
兔单克隆抗体[EPR2619(2)] to PSD95 (phospho T19) -
宿主
Rabbit -
经测试应用
适用于: WBmore details
不适用于: ICC/IF or IHC-P -
种属反应性
与反应: Human
预测可用于: Mouse, Rat
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免疫原
Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.
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阳性对照
- Fetal brain lysate.
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常规说明
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free production
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.20
Preservative: 0.01% Sodium azide
Constituents: 9% PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, 50% Tissue culture supernatant -
Concentration information loading... -
纯度
Tissue culture supernatant -
克隆
单克隆 -
克隆编号
EPR2619(2) -
同种型
IgG -
研究领域
相关产品
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Alternative Versions
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab172628于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB | (1) |
1/1000 - 1/10000. Predicted molecular weight: 80 kDa.
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| 说明 |
|---|
|
WB
1/1000 - 1/10000. Predicted molecular weight: 80 kDa. |
应用说明
Is unsuitable for ICC/IF or IHC-P.
靶标
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功能
Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B. -
组织特异性
Brain. -
序列相似性
Belongs to the MAGUK family.
Contains 1 guanylate kinase-like domain.
Contains 3 PDZ (DHR) domains.
Contains 1 SH3 domain. -
结构域
The PDZ domain 3 mediates interaction with ADR1B.
The L27 domain near the N-terminus of isoform 2 is required for HGS/HRS-dependent targeting to postsynaptic density. -
翻译后修饰
Palmitoylation of isoform 1 is required for targeting to postsynaptic density. -
细胞定位
Cell membrane. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell projection, axon. Cell junction, synapse. High levels in postsynaptic density of neurons in the forebrain. Also in presynaptic region of inhibitory synapses formed by cerebellar basket cells on axon hillocks of Purkinje cells. - Information by UniProt
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数据库链接
- Entrez Gene: 1742 Human
- Entrez Gene: 13385 Mouse
- Entrez Gene: 29495 Rat
- Omim: 602887 Human
- SwissProt: P78352 Human
- SwissProt: Q62108 Mouse
- SwissProt: P31016 Rat
- Unigene: 463928 Human
see all -
别名
- Discs large homolog 4 antibody
- Disks large homolog 4 antibody
- DLG 4 antibody
see all
图片
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Western blot - Anti-PSD95 (phospho T19) antibody [EPR2619(2)] (ab172628)All lanes : Anti-PSD95 (phospho T19) antibody [EPR2619(2)] (ab172628) at 1/1000 dilution
Lane 1 : Fetal brain lysate, untreated
Lane 2 : Fetal brain lysate, treated with Lambda Phosphatase
Lysates/proteins at 10 µg per lane.
Predicted band size: 80 kDa -
![Anti-PSD95 (phospho T19) antibody [EPR2619(2)] (ab172628)](https://www.abcam.cn/ps/products/172/ab172628/Images/ab172628-2-benefits-of-recombinant-antibodies.png)
Anti-PSD95 (phospho T19) antibody [EPR2619(2)] (ab172628)
数据表及文件
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SDS download
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Datasheet download
文献 (5)
ab172628 被引用在 5 文献中.
- Alhaddad H et al. Effects of chronic ethanol consumption on the expression of GLT-1 and neuroplasticity-related proteins in the nucleus accumbens of alcohol-preferring rats. Brain Res Bull 165:272-280 (2020). PubMed: 33075417
- Wang M et al. Decrease of GSK-3ß Activity in the Anterior Cingulate Cortex of Shank3b-/- Mice Contributes to Synaptic and Social Deficiency. Front Cell Neurosci 13:447 (2019). PubMed: 31749684
- Chowdhury D et al. Ca2+/calmodulin binding to PSD-95 mediates homeostatic synaptic scaling down. EMBO J 37:122-138 (2018). PubMed: 29118000
- Kim DH et al. SPIN90 Modulates Long-Term Depression and Behavioral Flexibility in the Hippocampus. Front Mol Neurosci 10:295 (2017). PubMed: 28979184
- Beurel E et al. Ketamine-induced inhibition of glycogen synthase kinase-3 contributes to the augmentation of a-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor signaling. Bipolar Disord 18:473-480 (2016). PubMed: 27687706