AB2218

Anti-Prostate Specific Antigen 抗体 [A67-B/E3]

Name: Prostate Specific Antigen抗体[A67-B/E3] (ab2218)| Abcam中文官网
Brand: Abcam Limited
SKU: AB2218
Price: 4695 CNY
Availability: InStock

Anti-Prostate Specific Antigen antibody [A67-B/E3]

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(1 Publication)

Mouse Monoclonal Prostate Specific Antigen antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication.

查看别名

APS, KLK3, Prostate-specific antigen, PSA, Gamma-seminoprotein, Kallikrein-3, P-30 antigen, Semenogelase, Seminin

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Prostate Specific Antigen antibody [A67-B/E3] (AB2218)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Prostate Specific Antigen antibody [A67-B/E3] (AB2218)

Immunohistochemical analysis of human prostate tissue sections staining Prostate Specific Antigen with ab2218.

Unknown

Western blot - Anti-Prostate Specific Antigen antibody [A67-B/E3] (AB2218)

All lanes:

Western blot - Anti-Prostate Specific Antigen antibody [A67-B/E3] (ab2218) at 5 µg/mL

All lanes:

Human Seminal Plasma

Secondary

All lanes:

IRDye800-conjugated Anti-Mouse IgG1 Secondary Antibody

Predicted band size: 29 kDa

Observed band size: 30 kDa

false

不同偶联物与剂型 (1)

Biotin

Biotin Anti-Prostate Specific Antigen antibody [A67-B/E3]

关键信息

宿主种属

Mouse

克隆

Monoclonal

克隆号

A67-B/E3

亚型

IgG1

轻链类型

unknown

不含载体蛋白

反应种属

Human

应用

WB, IHC-P

applications

特异性

This antibody is specific for PSA.

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "2-5 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p> Perform enzymatic antigen retrieval before commencing with IHC staining protocol." } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Protein A

纯化说明

Purified from TCS. Purified by precipitation and chromatography. Purity >95% by SDS-PAGE.

存储溶液

pH: 7.4 Preservative: 0.097% Sodium azide Constituents: PBS

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Prostate Specific Antigen (PSA) also known as kallikrein-related peptidase 3 (KLK3) is a serine protease with a mass of approximately 28.4 kDa. PSA is primarily expressed in the epithelial cells of the prostate gland. This glycoprotein is an important component in the seminal fluid where it performs its proteolytic activity that liquefies semen facilitating sperm motility.

Biological function summary

PSA functions by cleaving the gel-forming proteins present in seminal coagulum. It does not operate as part of a larger protein complex. PSA also interacts with substrates like fibronectin and semenogelin which play roles in seminal coagulation and liquefaction. The expression of PSA in prostate tissue has made it a valuable biomarker for prostate function and pathological conditions.

Pathways

PSA is involved in the kallikrein-kinin system which influences inflammation and blood pressure regulation. PSA is not directly a part of key metabolic or signaling pathways but it is co-expressed with key proteins like androgen receptor (AR) which modulates PSA's expression. The interplay between androgens and PSA highlights its role in hormone regulation within the male reproductive system.

PSA levels serve as an indicator for prostate cancer and benign prostatic hyperplasia (BPH). Elevated PSA levels often correlate with prostate cancer although other prostate conditions such as prostatitis can also increase PSA without cancer. Proteins like PCA3 and the AR are also connected in the context of prostate cancer providing a broader understanding of PSA's role in these diseases.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum.

See full target information KLK3

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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Oncoimmunology 11:2073050 PubMed35558161

2022

and mutations are associated with distinct blast immunophenotype in acute myeloid leukemia.

Applications

Unspecified application

Species

Unspecified reactive species

Kateřina Kuželová,Barbora Brodská,Jana Marková,Martina Petráčková,Johannes Schetelig,Šárka Ransdorfová,Zdenka Gašová,Cyril Šálek

View all publications

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Anti-Prostate Specific Antigen 抗体 [A67-B/E3]