AB140337

Anti-Prostate Specific Antigen 抗体 [3E6]

Name: Prostate Specific Antigen抗体[3E6] (ab140337)| Abcam中文官网
Brand: Abcam Limited
SKU: AB140337
Price: 4867 CNY
Availability: InStock

Anti-Prostate Specific Antigen antibody [3E6]

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(2 Publications)

Mouse Monoclonal Prostate Specific Antigen antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human KLK3.

查看别名

APS, KLK3, Prostate-specific antigen, PSA, Gamma-seminoprotein, Kallikrein-3, P-30 antigen, Semenogelase, Seminin

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Prostate Specific Antigen antibody [3E6] (AB140337)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Prostate Specific Antigen antibody [3E6] (AB140337)

Immunohistochemical analysis of paraffin-embedded Human prostate tissue labelling Prostate Specific Antigen (PSA) with ab140337 at dilution 1/100

Immunocytochemistry/ Immunofluorescence - Anti-Prostate Specific Antigen antibody [3E6] (AB140337)

ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-Prostate Specific Antigen antibody [3E6] (AB140337)

Immunofluorescent analysis of Human LNCaP cells labelling Prostate Specific Antigen (PSA) with ab140337 at dilution 1/100.

关键信息

宿主种属

Mouse

克隆

Monoclonal

克隆号

3E6

亚型

IgG1

轻链类型

kappa

不含载体蛋白

反应种属

Human

应用

IHC-P, ICC/IF

applications

免疫原

Recombinant Full Length Protein corresponding to Human KLK3.

P07288

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Protein G

存储溶液

pH: 7.2 Preservative: 0.09% Sodium azide Constituents: PBS

运输条件

Blue Ice

储存信息

Avoid freeze / thaw cycle|Store undiluted

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Prostate Specific Antigen (PSA) also known as kallikrein-related peptidase 3 (KLK3) is a serine protease with a mass of approximately 28.4 kDa. PSA is primarily expressed in the epithelial cells of the prostate gland. This glycoprotein is an important component in the seminal fluid where it performs its proteolytic activity that liquefies semen facilitating sperm motility.

Biological function summary

PSA functions by cleaving the gel-forming proteins present in seminal coagulum. It does not operate as part of a larger protein complex. PSA also interacts with substrates like fibronectin and semenogelin which play roles in seminal coagulation and liquefaction. The expression of PSA in prostate tissue has made it a valuable biomarker for prostate function and pathological conditions.

Pathways

PSA is involved in the kallikrein-kinin system which influences inflammation and blood pressure regulation. PSA is not directly a part of key metabolic or signaling pathways but it is co-expressed with key proteins like androgen receptor (AR) which modulates PSA's expression. The interplay between androgens and PSA highlights its role in hormone regulation within the male reproductive system.

PSA levels serve as an indicator for prostate cancer and benign prostatic hyperplasia (BPH). Elevated PSA levels often correlate with prostate cancer although other prostate conditions such as prostatitis can also increase PSA without cancer. Proteins like PCA3 and the AR are also connected in the context of prostate cancer providing a broader understanding of PSA's role in these diseases.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum.

See full target information KLK3

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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Molecular therapy. Nucleic acids 35:102322 PubMed39363882

2024

Highly efficient nucleic acid encapsulation method for targeted gene therapy using antibody conjugation system.

Applications

Unspecified application

Species

Unspecified reactive species

Seokbong Hong,Seung-Hwan Jeong,Jang Hee Han,Hyeong Dong Yuk,Chang Wook Jeong,Ja Hyeon Ku,Cheol Kwak

PloS one 11:e0154851 PubMed27152740

2016

Mas-Related Gene (Mrg) C Activation Attenuates Bone Cancer Pain via Modulating Gi and NR2B.

Applications

Unspecified application

Species

Unspecified reactive species

Yu'e Sun,Ming Jiang,Bailing Hou,Cui'e Lu,Yishan Lei,Zhengliang Ma,Xiaoping Gu

View all publications

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Abcam Product Promise

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详情请参阅我们的条款与条件。

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For licensing inquiries, please contact partnerships@abcam.com

Anti-Prostate Specific Antigen 抗体 [3E6]

Anti-Prostate Specific Antigen antibody [3E6]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Prostate Specific Antigen antibody [3E6] (AB140337)

Immunocytochemistry/ Immunofluorescence - Anti-Prostate Specific Antigen antibody [3E6] (AB140337)

关键信息

宿主种属

克隆

克隆号

亚型

轻链类型

不含载体蛋白

反应种属

应用

免疫原