Anti-Properdin/PFC抗体[10-18] (ab58984)
Key features and details
- Mouse monoclonal [10-18] to Properdin/PFC
- Suitable for: ELISA, IHC-Fr, Functional Studies
- Reacts with: Human
- Isotype: IgG1
概述
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产品名称
Anti-Properdin/PFC抗体[10-18]
参阅全部 Properdin/PFC 一抗 -
描述
小鼠单克隆抗体[10-18] to Properdin/PFC -
宿主
Mouse -
经测试应用
适用于: ELISA, IHC-Fr, Functional Studiesmore details -
种属反应性
与反应: Human -
免疫原
Full length native protein (purified) corresponding to Human Properdin/PFC.
Database link: P27918 -
阳性对照
- Histology positive control tissue: Kidney from post streptococcal glomerulonephritis patients.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
存储溶液
pH: 8.20
Preservative: 0.1% Sodium azide
Constituent: 99% Borate buffered saline -
Concentration information loading... -
纯度
Protein A purified -
克隆
单克隆 -
克隆编号
10-18 -
同种型
IgG1 -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab58984于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| ELISA | ||
| IHC-Fr | ||
| Functional Studies |
| 说明 |
|---|
FuncS: Use at an assay dependent dilution.
Note: This antibody inhibits the function of Properdin. Removal of sodium azide is recommended prior to use in functional assays
IHC-Fr: Use at an assay dependent dilution.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
靶标
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功能
A positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes. -
疾病相关
Defects in CFP are the cause of properdin deficiency (PFD) [MIM:312060]. PFD results in higher susceptibility to bacterial infections; especially to meningococcal infections. Three phenotypes have been reported: complete deficiency (type I), incomplete deficiency (type II), and dysfunction of properdin (type III). -
序列相似性
Contains 6 TSP type-1 domains. -
细胞定位
Secreted. - Information by UniProt
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数据库链接
- Entrez Gene: 5199 Human
- Omim: 300383 Human
- SwissProt: P27918 Human
- Unigene: 53155 Human
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别名
- BFD antibody
- CFP antibody
- Complement factor P antibody
see all
数据表及文件
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SDS download
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Datasheet download
文献 (0)
ab58984 尚未被引用在任何文献中。