AB58993

Anti-Prolyl Endopeptidase抗体

Name: Prolyl Endopeptidase抗体 (ab58993)| Abcam中文官网
Brand: Abcam Limited
SKU: AB58993
Price: 4606 CNY
Availability: InStock

Anti-Prolyl Endopeptidase antibody

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(1 Publication)

Rabbit Polyclonal Prolyl Endopeptidase antibody. Suitable for WB and reacts with Dog samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human PREP.

查看别名

PEP, PREP, Prolyl endopeptidase, PE, Post-proline cleaving enzyme

1 Images

Unknown

Western blot - Anti-Prolyl Endopeptidase antibody (AB58993)

All lanes:

Western blot - Anti-Prolyl Endopeptidase antibody (ab58993) at 1/1000 dilution

Lane 1:

Madin Darby canine kidney (MDCK) cell lysate at 10 µL

Lane 2:

Madin Darby canine kidney (MDCK) cell lysate at 5 µL

Predicted band size: 81 kDa

false

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Dog

应用

applications

免疫原

Synthetic Peptide within Human PREP. The exact immunogen used to generate this antibody is proprietary information.

P48147

特异性

ab58993 reacts with POP.

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Dog": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

存储溶液

pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 2.9% Sodium chloride

运输条件

Blue Ice

储存信息

Stable for 12 months at -20°C

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Prolyl endopeptidase also known as prolyl oligopeptidase is a serine peptidase with a molecular mass of about 80 kDa. It specifically cleaves peptide bonds at the C-terminal side of proline residues within short peptides. Prolyl endopeptidase is expressed widely including in brain and peripheral tissues making it a significant target in various cellular processes. This enzyme features a catalytic triad typical of serine proteases which consists of serine histidine and aspartate residues.

Biological function summary

Prolyl endopeptidase participates in the modulation and degradation of proline-containing peptides impacting neuropeptide activity and peptide hormone regulation. It operates largely outside of any complex functioning independently in its enzymatic roles. Its activity influences processes such as cell signaling and neurotransmission by altering the lifespans of bioactive peptides contributing to cellular homeostasis and communication efficacy.

Pathways

Four enzymes interact in a cascade that includes prolyl endopeptidase within the renin-angiotensin system and other neuropeptide pathways. Particularly noteworthy is its involvement in the hydrolysis of small bioactive peptides which links it to proteins like angiotensin-converting enzyme. Prolyl endopeptidase manipulates peptide availability influencing blood pressure control and cognitive functions by its participation in peptide-related pathways.

Four enzymes are implicated in cognitive disorders and cardiovascular diseases with prolyl endopeptidase playing a considerable role. Its aberrant activity relates to neurodegenerative diseases such as Alzheimer's disease and conditions like hypertension. In Alzheimer's altered activity affects amyloid-beta peptide processing and interaction with tau protein while in hypertension its regulation or dysregulation impacts peptide substrates affiliated with blood pressure modulation.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long.

See full target information PREP

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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Communications biology 7:183 PubMed38360932

2024

The Drosophila ZNRF1/2 homologue, detour, interacts with HOPS complex and regulates autophagy.

Applications

Unspecified application

Species

Unspecified reactive species

Shannon Nicolson,Jantina A Manning,Yoon Lim,Xin Jiang,Erica Kolze,Sonia Dayan,Ruchi Umargamwala,Tianqi Xu,Jarrod J Sandow,Andrew I Webb,Sharad Kumar,Donna Denton

View all publications

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Anti-Prolyl Endopeptidase抗体

Anti-Prolyl Endopeptidase antibody

Western blot - Anti-Prolyl Endopeptidase antibody (AB58993)

关键信息

宿主种属

克隆

亚型

不含载体蛋白

反应种属

应用

免疫原

特异性