AB119999

Anti-Prol1抗体

Name: Prol1抗体 (ab119999)| Abcam中文官网
Brand: Abcam Limited
SKU: AB119999
Price: 4606 CNY
Availability: InStock

Anti-Prol1 antibody

Be the first to review this product! Submit a review

(4 Publications)

Goat Polyclonal Prol1 antibody. Suitable for IHC-P and reacts with Mouse samples. Cited in 4 publications.

1 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Prol1 antibody (AB119999)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Prol1 antibody (AB119999)

ab119999 (2.9 μg/ml) staining of cells in the submandibular salivery gland (SMG), but not in the sublingual salivery gland (SLG) in mouse.

关键信息

宿主种属

Goat

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Mouse

应用

IHC-P

applications

style

left-column

反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" } } }

style

left-column

style

left-column

性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

纯化说明

ab119999 is purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.

存储溶液

pH: 7.3 Preservative: 0.02% Sodium azide Constituents: 99% Tris buffered saline, 0.5% BSA

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

style

left-column

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Prol1 also known as Prolargin or PRELP represents a small leucine-rich proteoglycan with an approximate mass around 40 kDa. It is largely expressed in connective tissues such as cartilage and skin. Prol1 helps in maintaining the structural integrity of the extracellular matrix by interacting with collagen and its expression levels can vary across different types of connective tissues. It's notable for binding with extracellular matrix components playing a role in tissue organization.

Biological function summary

Prol1 contributes significant roles in connective tissue development and maintenance. It's not typically part of larger protein complexes but it binds directly to structural proteins like collagen and other matrix molecules. Prol1 also shows activity in modulating cell adhesion processes impacting how cells interact with the surrounding matrix. This capacity allows it to influence tissue repair mechanisms and homeostasis.

Pathways

Prol1 interacts prominently in extracellular matrix organization pathways and the collagen fibril organization pathway. It closely associates with proteins like decorin and biglycan which are also part of the small leucine-rich proteoglycan family. Through these pathways Prol1 ensures proper collagen alignment and structural integrity affecting matrix homeostasis and tissue resilience.

Prol1 relates to conditions such as osteoarthritis and spondyloepimetaphyseal dysplasia. The disruption or mutation of Prol1 can lead to abnormal collagen deposition which affects joint functionality and cartilage integrity. Additionally interactions with proteins like collagen II have been observed in such conditions indicating Prol1's role in disease mechanisms. Understanding Prol1's impact on these disorders helps in developing targeted therapeutic approaches.

style

left-column

style

left-column

产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

style

left-column

靶点信息

See full target information Prol1

style

left-column

文献 (4)

Recent publications for all applications. Explore the full list and refine your search

Andrology 11:591-610 PubMed36374586

2022

Cytoskeletal protein SPTA1 mediating the decrease in erectile function induced by high-fat diet via Hippo signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Ying Chen,Lei Wang,Zhan-Sen Huang,Jia-Xin Feng,Shi-Xiong Li,Zi-Jun Du,Ze-Bo Zhang,Jing Liu,Jian Yang,Zhi-Ming Hu,Zhi-Lin Wang,Jun Chen

PloS one 16:e0245607 PubMed33465144

2021

Bmi-1 regulates mucin levels and mucin O-glycosylation in the submandibular gland of mice.

Applications

Unspecified application

Species

Unspecified reactive species

Akihiko Kameyama,Risa Nishijima,Kimi Yamakoshi

Nature communications 11:991 PubMed32080185

2020

Tracing tumorigenesis in a solid tumor model at single-cell resolution.

Applications

Unspecified application

Species

Unspecified reactive species

Samantha D Praktiknjo,Benedikt Obermayer,Qionghua Zhu,Liang Fang,Haiyue Liu,Hazel Quinn,Marlon Stoeckius,Christine Kocks,Walter Birchmeier,Nikolaus Rajewsky

Biochimica et biophysica acta. Proteins and proteomics 1867:76-81 PubMed29753090

2018

A rapid separation and characterization of mucins from mouse submandibular glands by supported molecular matrix electrophoresis.

Applications

Species

Unspecified reactive species

Akihiko Kameyama,Kimi Yamakoshi,Atsushi Watanabe

View all publications

style

left-column

style

left-column

style

right-column

Abcam Product Promise

我们致力于为您的研究提供高质量的试剂，为您科研的每一步提供支持。若我们的产品未能达到预期性能，我们向您提供 Abcam Product Promise 保障。

详情请参阅我们的条款与条件。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Prol1抗体

Anti-Prol1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Prol1 antibody (AB119999)